Evidence map›Paper›PMID 26200804›Full record

ArticleJournal of the American Geriatrics Society2015

Lower Extremity Proximal Muscle Function and Dyspnea in Older Persons.

Carlos A Vaz Fragoso, Katy Araujo, Linda Leo-Summers, Peter H Van Ness

Abstract readMulticenter Study
In one paragraph

Article in Journal of the American Geriatrics Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Carlos A Vaz FragosoDepartment of Internal Medicine, School of Medicine, Yale University, West Haven, Connecticut.
Katy AraujoDepartment of Internal Medicine, School of Medicine, Yale University, West Haven, Connecticut.
Linda Leo-SummersDepartment of Internal Medicine, School of Medicine, Yale University, West Haven, Connecticut.
Peter H Van NessDepartment of Internal Medicine, School of Medicine, Yale University, West Haven, Connecticut.

Funding

Yale Study Support Suite (YES3): Dashboard and Web Portal Software Supporting Research Workflow through integrated, customizable REDCap External ModulesP30AG021342 · NIA · YALE UNIVERSITY · PI Denise Esserman · 2002 to 2026
$37.9M
"Defining Chronic Obstructive Pulmonary Disease in Older Persons"R03AG037051 · NIA · YALE UNIVERSITY · PI FRAGOSO, CARLOS A. VAZ · 2010 to 2011
$133k
Respiratory Impairment in Aging PopulationsI01CX000927 · VA · VA CONNECTICUT HEALTHCARE SYSTEM · PI FRAGOSO, CARLOS A. VAZ · 2014 to 2016
–
CSRD VA I01 CX000927NIA NIH HHS P30 AG021342NIA NIH HHS P30AG021342NIA NIH HHS R03 AG037051
6 · The paper itself

Abstract

objectivesTo evaluate the association between performance on a single chair stand and moderate to severe exertional dyspnea.

designCross-sectional.

settingCardiovascular Health Study.

participantsCommunity-dwelling individuals aged 65 and older (N = 4,413; mean age 72.6; female, n = 2,518 (57.1%); nonwhite, n = 199 (4.5%); obese, n = 788 (17.9%); history of smoking, n = 2,410 (54.6%)). MEASUREMENTS: Performance on single chair stand (poor (unable to rise without arm use) vs normal (able to rise without arm use)), moderate to severe exertional dyspnea (American Thoracic Society grade ≥2), age, sex, ethnicity, obesity, smoking, frailty status (Fried-defined nonfrail, prefrail, frail), high cardiopulmonary risk (composite of cardiopulmonary diseases and diabetes mellitus), spirometric impairment, arthritis, depression, stroke, and kidney disease.

resultsPoor performance on the single chair stand was established in 369 (8.4%) and moderate to severe exertional dyspnea in 773 (17.5%). Prefrail status was established in 2,210 (50.1%), frail status in 360 (8.2%), arthritis in 2,241 (51.4%), high cardiopulmonary risk in 2,469 (55.9%), spirometric impairment in 1,076 (24.4%), kidney disease in 111 (2.5%), depression in 107 (2.4%), and stroke in 93 (2.1%). In multivariable regression models, poor performance on the single chair stand was associated with moderate to severe exertional dyspnea (unadjusted odds ratio (OR) = 3.48, 95% confidence interval (CI) = 2.78-4.36; adjusted OR = 1.85, 95% CI = 1.41-2.41).

conclusionPoor performance on a single chair stand was associated with an adjusted 85% greater likelihood of moderate to severe exertional dyspnea than normal performance. These results suggest that reduced proximal muscle function of the lower extremities is associated with moderate to severe exertional dyspnea, even after adjusting for multiple confounders.

Indexed as

Frail ElderlyAgedAged, 80 and overCross-Sectional StudiesDyspneaFemaleGeriatric AssessmentHumansLower ExtremityMaleMotor ActivityMuscle ContractionPrevalenceRetrospective StudiesSpirometryUnited Stateschair standdyspneaspirometry

Identifiers

PMID26200804
PMCPMC5283074

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.