ArticleRedox report : communications in free radical research2016
Thiol/disulfide homeostasis: A prognostic biomarker for patients with advanced non-small cell lung cancer?
Article in Redox report : communications in free radical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 87 citations in OpenAlex.
- Thiol-disulfide homeostasis in ovarian cancer: comparative analysis with benign neoplasia and healthy women.Turkish journal of obstetrics and gynecology · 2026Article
- Thiol/Disulfide Homeostasis in Lung Cancer: Insights from a Clinical Study.Antioxidants (Basel, Switzerland) · 2026Article
- Protein oxidation, glycation, and carbamylation in patients with adrenal masses.Frontiers in molecular biosciences · 2026Article
- Evaluating the impact of radiotherapy on nitrosative stress and thiol/disulfide dynamics in patients with lung cancer.Scientific reports · 2025Article
- Nanomedicine-Driven Modulation of Reductive Stress for Cancer Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Thiol-disulfide homeostasis and ischemia modified albumin levels in patients diagnosed with ovary carcinoma.Scientific reports · 2025Article
- Analytical Methods for Assessing Thiol Antioxidants in Biological Fluids: A Review.Molecules (Basel, Switzerland) · 2024Review
- Thiol/Disulfide Homeostasis: A New Oxidative Marker in Heart Failure Patients with Preserved Ejection Fraction.Anatolian journal of cardiology · 2024Article
- Physical frailty is related to oxidative stress through thiol/disulfide homeostasis parameters.European geriatric medicine · 2024Article
- Article
- Disulfidptosis status influences prognosis and therapeutic response in clear cell renal cell carcinoma.Aging · 2024Article
- Selenium in cancer management: exploring the therapeutic potential.Frontiers in oncology · 2024Review
- Review
- Interplay between Comprehensive Inflammation Indices and Redox Biomarkers in Testicular Germ-Cell Tumors.Journal of personalized medicine · 2022Article
- A Predictor of Oxidative Stress in the Children with Measles: Thiol-Disulfide Homeostasis.Turkish archives of pediatrics · 2022Article
- Oxidative Stress Predicts Post-Surgery Complications in Gastrointestinal Cancer Patients.Annals of surgical oncology · 2022Article
- Strenuous swimming raises blood non-enzymatic antioxidant capacity in rats.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2022Article
- Antitumor Effects of Selenium.International journal of molecular sciences · 2021Review
- Variations of Thiol-Disulfide Homeostasis Parameters after Treatment with H1-Antihistamines in Patients with Chronic Spontaneous Urticaria.Journal of clinical medicine · 2021Article
- Immune cell - produced ROS and their impact on tumor growth and metastasis.Redox biology · 2021Review
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to investigate oxidative stress and thiol/disulfide status with a novel automated homeostasis assay in advanced non-small cell lung cancer (NSCLC).
methodsThirty-five patients with advanced NSCLC, who had been newly diagnosed and previously untreated, and 35 healthy subjects were chosen for the study. We measured plasma total thiol (-SH+-S-S-), native thiol (thiol) (-SH), and disulfide (-S-S-) levels in the patients with NSCLC and the healthy subjects. The thiol/disulfide (-SH/-S-S-) ratio was also calculated.
resultsStatistically significant differences between the patient group and the control group were detected for the thiol/disulfide parameters. The mean native thiol, total thiol, and disulfide levels were significantly lower in the group with advanced stage NSCLC. The cut-off value was 313 and 13.8 for native thiol and disulfide, respectively. Median overall survival (OS) was significantly shorter in patients with low native thiol and disulfide levels according to the cut-off value (respectively, P = 0.001; P = 0.006). Native thiol, total thiol, and disulfide levels were correlated with Karnofsky performance status (KPS), OS, and age. Additionally, hierarchical regression analyses showed gender, KPS, lung metastases, and plasma native thiol levels were the determinants of OS in the final model.
conclusionThese results suggest that in advanced stage NSCLC, the native thiol, total thiol, and disulfide levels decrease, while the native thiol/disulfide ratio does not change. Low levels of thiol/disulfide parameters are related to tumor aggressiveness and may predict a poor outcome for patients with NSCLC.
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