Evidence map›Paper›PMID 26200712›Full record

ArticleMemorias do Instituto Oswaldo Cruz2015

Full-length infectious clone of a low passage dengue virus serotype 2 from Brazil.

Jefferson José da Silva Santos, Tereza Magalhães, José Valter Joaquim Silva Junior, Andréa Nazaré Monteiro Rangel da Silva, Marli Tenório Cordeiro, Laura Helena Vega Gonzales Gil

Abstract read
In one paragraph

Article in Memorias do Instituto Oswaldo Cruz, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Immunofluorescence Assay.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  2. Article
  3. Reverse Genetics of Dengue Virus.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jefferson José da Silva SantosLaboratório de Virologia e Terapia Experimental, Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, Recife, PE, BR.
Tereza MagalhãesLaboratório de Virologia e Terapia Experimental, Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, Recife, PE, BR.
José Valter Joaquim Silva JuniorLaboratório de Virologia e Terapia Experimental, Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, Recife, PE, BR.
Andréa Nazaré Monteiro Rangel da SilvaLaboratório de Virologia e Terapia Experimental, Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, Recife, PE, BR.
Marli Tenório CordeiroLaboratório de Virologia e Terapia Experimental, Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, Recife, PE, BR.
Laura Helena Vega Gonzales GilLaboratório de Virologia e Terapia Experimental, Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, Recife, PE, BR.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Full-length dengue virus (DENV) cDNA clones are an invaluable tool for many studies, including those on the development of attenuated or chimeric vaccines and on host-virus interactions. Furthermore, the importance of low passage DENV infectious clones should be highlighted, as these may harbour critical and unique strain-specific viral components from field-circulating isolates. The successful construction of a functional Brazilian low passage DENV serotype 2 full-length clone through homologous recombination reported here supports the use of a strategy that has been shown to be highly useful by our group for the development of flavivirus infectious clones and replicons.

Indexed as

BrazilCloning, MolecularDengue VirusDNA, ComplementaryMolecular Sequence DataRNA, ViralSequence Analysis, DNAVirus ReplicationDNA, ComplementaryRNA, Viral

Identifiers

PMID26200712
PMCPMC4569833

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.