Evidence map›Paper›PMID 26200658›Full record

ArticlePloS one2015

Medication Use before, during, and after Pregnancy among Women with Eating Disorders: A Study from the Norwegian Mother and Child Cohort Study.

Angela Lupattelli, Olav Spigset, Leila Torgersen, Stephanie Zerwas, Marianne Hatle, Ted Reichborn-Kjennerud, Cynthia M Bulik, Hedvig Nordeng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Angela LupattelliPharmacoEpidemiology and Drug Safety Research Group, School of Pharmacy, PharmaTox Strategic Initiative, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway.
Olav SpigsetDepartment of Clinical Pharmacology, St Olav's University Hospital, Trondheim, Norway; Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway.
Leila TorgersenDivision of Mental Health, Norwegian Institute of Public Health, Oslo, Norway.
Stephanie ZerwasUNC Center of Excellence for Eating Disorders, Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Marianne HatleClinic for Eating Disorders, Oslo, Norway.
Ted Reichborn-KjennerudDivision of Mental Health, Norwegian Institute of Public Health, Oslo, Norway; Department of Psychiatry, University of Oslo, Oslo, Norway.
Cynthia M BulikUNC Center of Excellence for Eating Disorders, Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Hedvig NordengPharmacoEpidemiology and Drug Safety Research Group, School of Pharmacy, PharmaTox Strategic Initiative, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway; Division of Mental Health, Norwegian Institute of Public Health, Oslo, Norway.

Funding

Gene-Environment Interactions in an Autism Birth CohortU01NS047537 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LIPKIN, W. IAN · 2003 to 2013
$27.0M
Eating Disorders and Pregnancy Outcome in 100,000 BirthsR01HD047186 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M · 2005 to 2007
$1.4M
Developmental Psychopathology of Restrictive and Binge Eating in ChildhoodK01MH100435 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZERWAS, STEPHANIE CHRISTINE · 2013 to 2015
$488k
NICHD NIH HHS HD047186NICHD NIH HHS R01 HD047186NIEHS NIH HHS N01 ES075558NIEHS NIH HHS N01-ES-75558NIMH NIH HHS K01 MH100435NINDS NIH HHS 1 U01 NS 047537-01NINDS NIH HHS 2 U01 NS 047537-06A1NINDS NIH HHS U01 NS047537
6 · The paper itself

Abstract

introductionLittle is known about medication use among women with eating disorders in relation to pregnancy.

aimsTo explore patterns of and associations between use of psychotropic, gastrointestinal and analgesic medications and eating disorders in the period before, during and after pregnancy.

methodThis study is based on the Norwegian Mother and Child Cohort Study (MoBa). A total of 62,019 women, enrolled at approximately 17 weeks' gestation, had valid data from the Norwegian Medical Birth Registry and completed three MoBa questionnaires. The questionnaires provided diagnostic information on broadly defined anorexia nervosa (AN), bulimia nervosa (BN), binge eating disorder (BED) and recurrent self-induced purging in the absence of binge eating (EDNOS-P), along with self-reported use of medication six months before, during, and 0-6 months after pregnancy.

resultsThe prevalence of eating disorder subtypes before and/or during pregnancy was: 0.09% AN (n = 54), 0.94% BN (n = 585), 0.10% EDNOS-P (n = 61) and 5.00% BED (n = 3104). The highest over-time prevalence of psychotropic use was within the AN (3.7-22.2%) and EDNOS-P (3.3-9.8%) groups. Compared to controls, BN was directly associated with incident use of psychotropics in pregnancy (adjusted RR: 2.25, 99% CI: 1.17-4.32). Having AN (adjusted RR: 5.11, 99% CI: 1.53-17.01) or EDNOS-P (adjusted RR: 6.77, 99% CI: 1.41-32.53) was directly associated with use of anxiolytics/sedatives postpartum. The estimates of use of analgesics (BED) and laxatives (all eating disorders subtypes) were high at all time periods investigated.

conclusionsUse of psychotropic, gastrointestinal, and analgesic medications is extensive among women with eating disorders in the period around pregnancy. Female patients with eating disorders should receive evidence-based counseling about the risk of medication exposure versus the risk of untreated psychiatric illness during pregnancy and postpartum.

Indexed as

AdultAnalgesicsFeeding and Eating DisordersFemaleHumansLaxativesNorwayPostnatal CarePregnancyPrenatal CarePsychotropic DrugsSurveys and QuestionnairesYoung AdultAnalgesicsLaxativesPsychotropic Drugs

Identifiers

PMID26200658
PMCPMC4511584

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.