Evidence map›Paper›PMID 26200224›Full record

ReviewInvestigative radiology2015

Ultrasound in Radiology: From Anatomic, Functional, Molecular Imaging to Drug Delivery and Image-Guided Therapy.

Alexander L Klibanov, John A Hossack

Abstract readReview
In one paragraph

Review in Investigative radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Sex-specific predictive equations for estimating trochanteric soft tissue thickness across body positions and imaging modalities.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Alexander L KlibanovFrom the *Cardiovascular Division, Robert M. Berne Cardiovascular Research Center, School of Medicine, and †Department of Biomedical Engineering, University of Virginia, Charlottesville VA.
John A Hossack

Funding

QUANTITATIVE 3D ULTRASOUND IMAGING OF THE MURINE HEARTR01EB001826 · NIBIB · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI HOSSACK, JOHN A · 2003 to 2012
$2.4M
Molecular Targeted, Focused, Ultrasound-Based Delivery of Antiproliferative DrugsR01HL090700 · NHLBI · UNIVERSITY OF VIRGINIA · PI HOSSACK, JOHN A · 2008 to 2012
$1.8M
Ultrasound Targeted Molecular Imaging in Large Arteries to Diagnose Stroke RiskR01HL111077 · NHLBI · UNIVERSITY OF VIRGINIA · PI HOSSACK, JOHN A · 2012 to 2015
$1.4M
LOW-COST, MULTI-DIMENSIONAL, PORTABLE ULTRASOUND IMAGINGR01EB002349 · NIBIB · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI HOSSACK, JOHN A · 2003 to 2006
$1.2M
Image-guided Ultrasound-triggered Tumor TherapyR33CA102880 · NCI · UNIVERSITY OF VIRGINIA · PI KLIBANOV, ALEXANDER L · 2008 to 2011
$1.1M
Nanotherapeutics for acute kidney injuryR21DK093841 · NIDDK · UNIVERSITY OF VIRGINIA · PI KLIBANOV, ALEXANDER L, OKUSA, MARK DOUGLAS · 2012 to 2013
$425k
Ultrasound-triggered drug delivery with acoustically active red blood cellsR21EB016752 · NIBIB · UNIVERSITY OF VIRGINIA · PI KLIBANOV, ALEXANDER L · 2013 to 2014
$421k
Image-guided Ultrasound-triggered Tumor TherapyR21CA102880 · NCI · UNIVERSITY OF VIRGINIA · PI KLIBANOV, ALEXANDER L · 2007 to 2007
$205k
NCI NIH HHS CA102880NCI NIH HHS R21 CA102880NCI NIH HHS R33 CA102880NHLBI NIH HHS HL090700NHLBI NIH HHS HL111077NHLBI NIH HHS R01 HL090700NHLBI NIH HHS R01 HL111077NIBIB NIH HHS EB001826NIBIB NIH HHS EB002349NIBIB NIH HHS EB016752NIBIB NIH HHS R01 EB001826NIBIB NIH HHS R01 EB002349NIBIB NIH HHS R21 EB016752NIDDK NIH HHS DK093841NIDDK NIH HHS R21 DK093841
6 · The paper itself

Abstract

During the past decade, ultrasound has expanded medical imaging well beyond the "traditional" radiology setting: a combination of portability, low cost, and ease of use makes ultrasound imaging an indispensable tool for radiologists as well as for other medical professionals who need to obtain imaging diagnosis or guide a therapeutic intervention quickly and efficiently. Ultrasound combines excellent ability for deep penetration into soft tissues with very good spatial resolution, with only a few exceptions (ie, those involving overlying bone or gas). Real-time imaging (up to hundreds and thousands of frames per second) enables guidance of therapeutic procedures and biopsies; characterization of the mechanical properties of the tissues greatly aids with the accuracy of the procedures. The ability of ultrasound to deposit energy locally brings about the potential for localized intervention encompassing the following: tissue ablation, enhancing penetration through the natural barriers to drug delivery in the body and triggering drug release from carrier microparticles and nanoparticles. The use of microbubble contrast agents brings the ability to monitor and quantify tissue perfusion, and microbubble targeting with ligand-decorated microbubbles brings the ability to obtain molecular biomarker information, that is, ultrasound molecular imaging. Overall, ultrasound has become the most widely used imaging modality in modern medicine; it will continue to grow and expand.

Indexed as

Drug Delivery SystemsHumansMolecular ImagingUltrasonographyUltrasonography, Interventional

Identifiers

PMID26200224
PMCPMC4580624

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.