Evidence map›Paper›PMID 26199871›Full record

ArticleNeuroImage. Clinical2015

Parietal dysfunction during number processing in children with fetal alcohol spectrum disorders.

K J Woods, E M Meintjes, C D Molteno, S W Jacobson, J L Jacobson

Open access · goldAbstract read
In one paragraph

Article in NeuroImage. Clinical, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 35 citations in OpenAlex.

  1. Trial
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  7. Reading impairment in adolescents with fetal alcohol spectrum disorders.Scientific studies of reading : the official journal of the Society for the Scientific Study of Reading · 2022
    Article
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  13. Article
  14. Effects of Fetal Substance Exposure on Offspring Substance Use.Pediatric clinics of North America · 2019
    Review
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  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

K J WoodsMRC/UCT Medical Imaging Research Unit, University of Cape Town, Cape Town, South Africa ; Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
E M MeintjesMRC/UCT Medical Imaging Research Unit, University of Cape Town, Cape Town, South Africa ; Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
C D MoltenoDepartment of Psychiatry and Mental Health, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
S W JacobsonDepartment of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa ; Department of Psychiatry and Mental Health, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa ; Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA.
J L JacobsonDepartment of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa ; Department of Psychiatry and Mental Health, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa ; Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA.
University of Cape Town · ZA

Funding

FASD Diagnostic Telemedicine ResourceU24AA014815 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Lauren Gist, SARAH N MATTSON WELLER · 2003 to 2026
$5.6M
Neural Bases of Eyeblink Conditioning in FASDR01AA016781 · NIAAA · WAYNE STATE UNIVERSITY · PI JACOBSON, SANDRA W. · 2008 to 2012
$2.5M
Identification of FASD in South African ChildrenU01AA014790 · NIAAA · WAYNE STATE UNIVERSITY · PI JACOBSON, SANDRA W. · 2003 to 2005
$501k
Neuroimaging Studies of FAS Children in South AfricaR03TW007030 · FIC · WAYNE STATE UNIVERSITY · PI JACOBSON, SANDRA W. · 2005 to 2007
$106k
BIOLOGICAL AND CULTURAL DETERMINANTS OF ALCOHOLR01AA006781 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI HEATH, ANDREW C. · 1985 to 1988
–
FIC NIH HHS R03 TW007030NIAAA NIH HHS R01 AA006781NIAAA NIH HHS R01 AA016781NIAAA NIH HHS U01 AA014790NIAAA NIH HHS U01-AA014790NIAAA NIH HHS U24 AA014815NIAAA NIH HHS U24AA014815
6 · The paper itself

Abstract

Number processing deficits are frequently seen in children prenatally exposed to alcohol. Although the parietal lobe, which is known to mediate several key aspects of number processing, has been shown to be structurally impaired in fetal alcohol spectrum disorders (FASD), effects on functional activity in this region during number processing have not previously been investigated. This fMRI study of 49 children examined differences in activation associated with prenatal alcohol exposure in five key parietal regions involved in number processing, using tasks involving simple addition and magnitude comparison. Despite generally similar behavioral performance, in both tasks greater prenatal alcohol exposure was related to less activation in an anterior section of the right horizontal intraparietal sulcus known to mediate mental representation and manipulation of quantity. Children with fetal alcohol syndrome and partial fetal alcohol syndrome appeared to compensate for this deficit by increased activation of the angular gyrus during the magnitude comparison task.

Indexed as

Mathematical ConceptsChildFemaleFetal Alcohol Spectrum DisordersHumansMagnetic Resonance ImagingMaleParietal LobeThinkingAA, absolute alcoholADHD, attention-deficit/hyperactivity disorderANOVA, analysis of varianceARND, alcohol-related neurodevelopmental disorderDD, developmental dyscalculiaEA_CTL, control block in the exact addition taskEA, exact additionFASD, fetal alcohol spectrum disordersFAS, fetal alcohol syndromeFetal alcohol spectrum disordersFetal alcohol syndromefMRIHE, heavily exposedIPS, intraparietal sulcusLSD, least-squares differenceMagnitude comparisonNumber processingParietalPFAS, partial fetal alcohol syndromePJ_CTL, control block in the proximity judgment taskPJ, proximity judgmentPrenatal alcohol exposurePSPL, posterior superior parietal lobuleROI, region of interestTS, Turner syndromeUCT, University of Cape TownVBM, voxel-based morphometryWISC-III, Wechsler Intelligence Scale for Children, Third Edition

Identifiers

PMID26199871
PMCPMC4506983
OpenAlexW2054137330

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.