Evidence map›Paper›PMID 26199568›Full record

ArticleContemporary oncology (Poznan, Poland)2015

Genistein-induced mir-23b expression inhibits the growth of breast cancer cells.

Cigir Biray Avci, Sunde Yilmaz Susluer, Hasan Onur Caglar, Tugce Balci, Duygu Aygunes, Yavuz Dodurga, Cumhur Gunduz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary oncology (Poznan, Poland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 44 citations in OpenAlex.

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  4. Genistein Promotes Skeletal Muscle Regeneration by Regulating miR-221/222.International journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Cigir Biray AvciDepartment of Medical Biology, Medical Faculty, Ege University, Bornova, Izmir, Turkey.
Sunde Yilmaz SusluerDepartment of Medical Biology, Medical Faculty, Ege University, Bornova, Izmir, Turkey.
Hasan Onur CaglarDepartment of Stem Cell, Health Science Institute, Ege University, Bornova, Izmir, Turkey.
Tugce BalciDepartment of Medical Biology, Medical Faculty, Ege University, Bornova, Izmir, Turkey.
Duygu AygunesDepartment of Medical Biology, Medical Faculty, Ege University, Bornova, Izmir, Turkey.
Yavuz DodurgaDepartment of Medical Biology, School of Medicine, Pamukkale University, Denizli, Turkey.
Cumhur GunduzDepartment of Medical Biology, Medical Faculty, Ege University, Bornova, Izmir, Turkey.
Ege University · TRPamukkale University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aim of the studyGenistein, an isoflavonoid, plays roles in the inhibition of protein tyrosine kinase phosphorylation, induction of apoptosis, and cell differentiation in breast cancer. This study aims to induce cellular stress by exposing genistein to determine alterations of miRNA expression profiles in MCF-7 cells. MATERIAL AND

methodsXTT assay and trypan blue dye exclusion assays were performed to examine the cytotoxic effects of genistein treatment. Expressions of miRNAs were quantified using Real-Time Online RT-PCR.

resultsThe IC50 dose of genistein was 175 μM in MCF-7 cell, line and the cytotoxic effect of genistein was detected after 48 hours. miR-23b was found to be up-regulated 56.69 fold following the treatment of genistein. It was found that miR-23b was upregulated for MCF-7 breast cancer cells after genistein treatment.

conclusionsUp-regulated ex-expression of miR-23b might be a putative biomarker for use in the therapy of breast cancer patients. miR-23b up-regulation might be important in terms of response to genistein.

Indexed as

breast cancergenisteinMCF-7miRNA

Identifiers

PMID26199568
PMCPMC4507883
OpenAlexW2127516949

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.