ArticleJournal of ginseng research2015
Chemoprevention of chemical-induced skin cancer by Panax ginseng root extract.
Article in Journal of ginseng research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 47 citations in OpenAlex.
- Targeting Skin Cancer with Natural Bioactive Compounds: From Molecular Mechanisms to Application Strategies.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Determination of phytonutrients, antioxidant properties and in vitro effect of the microgreen3 Biotech · 2025Article
- Antitumor components and mechanisms ofFrontiers in pharmacology · 2025Review
- Anticolon Cancer Effect of Korean Red Ginseng via Autophagy- and Apoptosis-Mediated Cell Death.Nutrients · 2022Article
- Near-infrared light-triggered nano-prodrug for cancer gas therapy.Journal of nanobiotechnology · 2021Review
- Plant Natural Products: Promising Resources for Cancer Chemoprevention.Molecules (Basel, Switzerland) · 2021Review
- Radix et Rhizoma Ginseng chemoprevents both initiation and promotion of cutaneous carcinoma by enhancing cell-mediated immunity and maintaining redox homeostasis.Journal of ginseng research · 2020Article
- ZnS@ZIF-8 core-shell nanoparticles incorporated with ICG and TPZ to enable HTheranostics · 2020Article
- Novel ginsenoside-based multifunctional liposomal delivery system for combination therapy of gastric cancer.Theranostics · 2019Article
- Functional role of ginseng-derived compounds in cancer.Journal of ginseng research · 2018Review
- A herbal formula, comprisingSaudi journal of biological sciences · 2017Article
- Implications of redJournal of ginseng research · 2017Review
- Control Efficacy ofMycobiology · 2017Article
- Bioconversion, health benefits, and application of ginseng and red ginseng in dairy products.Food science and biotechnology · 2017Article
- Inhibitory Effect of Ginseng on Breast Cancer Cell Line Growth Via Up-Regulation of Cyclin Dependent Kinase Inhibitor, p21 and p53Asian Pacific journal of cancer prevention : APJCP · 2016Article
- Antifungal Substances from Streptomyces sp. A3265 Antagonistic to Plant Pathogenic Fungi.Mycobiology · 2015Article
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Authors and funding
2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundCancer has emerged as a major health problem globally as a consequence to the increased longevity of the population, changing the environment and life style. Chemoprevention is a new and promising strategy for reducing cancer burden. Recently, some natural products have been identified for their chemopreventive activity to reduce the cancer incidence. Ginseng is known for its potential to treat various ailments in human beings. The present study was designed to explore the anticancer and antioxidative potential of Panax ginseng against chemical-induced skin carcinogenesis in mammals.
methodsSkin tumors were induced in Swiss albino mice by a single topical application of 7,12-dimethylbenz(a)anthracene (100 μg/100 μL acetone) and, 2 wks later, promoted by repeated applications of croton oil (thrice in a wk in 1% acetone) till the end of the experiment (i.e., 16 wk). Hydroalcoholic ginseng root extract at a dose of 25 mg/kg body weight/d was orally administered at the peri-initiation, postinitiation, and peri-post-initiation stages.
resultsGinseng root extract treatment caused a significant reduction in tumor incidence, cumulative number of tumors, tumor yield, and tumor burden, as compared to the 7,12-dimethylbenz(a)anthracene-croton oil-treated control group. Further, biochemical assays revealed a significant enhancement in the levels of reduced glutathione, superoxide dismutase, catalase, vitamin C, and total proteins but a significant reduction in lipid peroxidation levels in both the liver and skin with ginseng root extract treatment, as compared to carcinogen-treated control group.
conclusionThese results suggest that P. ginseng has the potential to become a pivotal chemopreventive agent that can reduce cancer in mammals.
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