Evidence map›Paper›PMID 26199556›Full record

ArticleJournal of ginseng research2015

Effects of Korean Red Ginseng extract on busulfan-induced dysfunction of the male reproductive system.

Seok-Won Jung, Hyeon-Joong Kim, Byung-Hwan Lee, Sun-Hye Choi, Hyun-Sook Kim, Yang-Kyu Choi, Joon Yong Kim, Eun-Soo Kim, Sung-Hee Hwang, Kwang Yong Lim and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ginseng research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 53 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Seok-Won JungGinsentology Research Laboratory, Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University, Seoul, Korea.
Hyeon-Joong KimGinsentology Research Laboratory, Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University, Seoul, Korea.
Byung-Hwan LeeGinsentology Research Laboratory, Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University, Seoul, Korea.
Sun-Hye ChoiGinsentology Research Laboratory, Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University, Seoul, Korea.
Hyun-Sook KimGinsentology Research Laboratory, Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University, Seoul, Korea.
Yang-Kyu ChoiDepartment of Laboratory Animal Medicine, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University, Seoul, Korea.
Joon Yong KimVeterinary Medical Teaching Hospital, Konkuk University, Seoul, Korea.
Eun-Soo KimDepartment of Biological Science, College of Bioscience and Biotechnology, Konkuk University, Seoul, Korea.
Sung-Hee HwangDepartment of Pharmaceutical Engineering, Sangji University, Wonju, Korea.
Kwang Yong LimNeuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chuncheon, Korea.
Hyoung-Chun KimNeuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chuncheon, Korea.
Minhee JangDepartment of Convergence Medical Science, College of Oriental Medicine, Kyung Hee University, Seoul, Korea.
Seong Kyu ParkDepartment of Prescriptionology, College of Oriental Medicine, Kyung Hee University, Seoul, Korea.
Ik-Hyun ChoDepartment of Convergence Medical Science, College of Oriental Medicine, Kyung Hee University, Seoul, Korea.
Seung-Yeol NahGinsentology Research Laboratory, Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University, Seoul, Korea.
Konkuk University · KRKangwon National University · KRKyung Hee University · KRKonkuk University Medical Center · KRSangji University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAnticancer agents induce a variety of adverse effects when administered to cancer patients. Busulfan is a known antileukemia agent. When administered for treatment of leukemia in young patients, busulfan could cause damage to the male reproductive system as one of its adverse effects, resulting in sterility.

methodsWe investigated the effects of Korean Red Ginseng extract (KRGE) on busulfan-induced damage and/or dysfunction of the male reproductive system.

resultsWe found that administration of busulfan to mice: decreased testis weight; caused testicular histological damage; reduced the total number of sperm, sperm motility, serum testosterone concentration; and eventually, litter size. Preadministration of KRGE partially attenuated various busulfan-induced damages to the male reproductive system. These results indicate that KRGE has a protective effect against busulfan-induced damage to the male reproduction system.

conclusionThe present study shows a possibility that KRGE could be applied as a useful agent to prevent or protect the male reproductive system from the adverse side effects induced by administration of anticancer agents such as busulfan.

Indexed as

adverse effectsanticancerbusulfanPanax ginsengreproductive systems

Identifiers

PMID26199556
PMCPMC4506375
OpenAlexW2171703178

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.