Evidence map›Paper›PMID 26199465›Full record

Trial reportMediators of inflammation2015

Intranasal Dexmedetomidine on Stress Hormones, Inflammatory Markers, and Postoperative Analgesia after Functional Endoscopic Sinus Surgery.

Chaoliang Tang, Xiang Huang, Fang Kang, Xiaoqing Chai, Song Wang, Guobing Yin, Hongtao Wang, Juan Li

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Mediators of inflammation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04327726 (Effectiveness of Nebulized Dexmedetomidine for Treatment of Post-Dural Puncture Headache in Parturients Undergoing Elective Cesarean Section Under Spinal Anesthesia), which is not on this map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04327726 nacompletednot on this mapstarted 2020, after this paper: background citation

Effectiveness of Nebulized Dexmedetomidine for Treatment of Post-Dural Puncture Headache in Parturients Undergoing Elective Cesarean Section Under Spinal Anesthesia: Randomized Controlled Study

TypeinterventionalSponsorZagazig UniversityRan2020 to 2021Enrolled43ConditionsPost-Dural Puncture HeadacheArmsDexmedetomidine Nebulization, 0.9% Saline Nebulization
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 63 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Chaoliang TangDepartment of Anesthesiology, Anhui Provincial Hospital, Anhui Medical University, Hefei, China.
Xiang HuangDepartment of Anesthesiology, Anhui Provincial Hospital, Anhui Medical University, Hefei, China.
Fang KangDepartment of Anesthesiology, Anhui Provincial Hospital, Anhui Medical University, Hefei, China.
Xiaoqing ChaiDepartment of Anesthesiology, Anhui Provincial Hospital, Anhui Medical University, Hefei, China.
Song WangDepartment of Anesthesiology, Anhui Provincial Hospital, Anhui Medical University, Hefei, China.
Guobing YinDepartment of Anesthesiology, Anhui Provincial Hospital, Anhui Medical University, Hefei, China.
Hongtao WangDepartment of Anesthesiology, Anhui Provincial Hospital, Anhui Medical University, Hefei, China.
Juan LiDepartment of Anesthesiology, Anhui Provincial Hospital, Anhui Medical University, Hefei, China.
Anhui Medical University · CNAnhui Provincial Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA strong ongoing intraoperative stress response can cause serious adverse reactions and affect the postoperative outcome. This study evaluated the effect of intranasally administered dexmedetomidine (DEX) in combination with local anesthesia (LA) on the relief of stress and the inflammatory response during functional endoscopic sinus surgery (FESS).

methodsSixty patients undergoing FESS were randomly allocated to receive either intranasal DEX (DEX group) or intranasal saline (Placebo group) 1 h before surgery. Stress hormones, inflammatory markers, postoperative pain relief, hemodynamic variables, blood loss, surgical field quality, body movements, and satisfaction were assessed.

resultsPlasma epinephrine, norepinephrine, and blood glucose levels were significantly lower in DEX group as were the plasma IL-6 and TNF-α levels (P < 0.05). The weighted areas under the curve (AUCw) of the VAS scores were also significantly lower in DEX group at 2-12 h after surgery (P < 0.001). Furthermore, hemodynamic variables, blood loss, body movements, discomfort with hemostatic stuffing, surgical field quality, and satisfaction scores of patients and surgeons were significantly better (P < 0.05) in DEX group.

conclusionsPatients receiving intranasal DEX with LA for FESS exhibited less perioperative stress and inflammatory response as well as better postoperative comfort with hemostatic stuffing and analgesia.

Indexed as

AdultAnalgesiaBlood GlucoseDexmedetomidineDouble-Blind MethodEndoscopyEpinephrineFemaleHumansInflammationInterleukin-6MaleMiddle AgedNorepinephrineTumor Necrosis Factor-alphaBlood GlucoseDexmedetomidineEpinephrineInterleukin-6NorepinephrineTumor Necrosis Factor-alpha

Identifiers

PMID26199465
PMCPMC4496499
OpenAlexW1608674761

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.