ArticleProceedings of the National Academy of Sciences of the United States of America2015
Tissue fusion over nonadhering surfaces.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis.Current biology : CB · 2026Article
- Regeneration in calcareous sponge relies on 'purse-string' mechanism and the rearrangements of actin cytoskeleton.Cell and tissue research · 2023Article
- Geometry-mediated bridging drives nonadhesive stripe wound healing.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Proximate larval epidermal cell layer generates forces for Pupal thorax closure in Drosophila.Genetics · 2022Article
- Collective durotaxis of cohesive cell clusters on a stiffness gradient.The European physical journal. E, Soft matter · 2022Article
- Microfabricated Gaps Reveal the Effect of Geometrical Control in Wound Healing.Advanced healthcare materials · 2021Article
- Adhesion-mediated heterogeneous actin organization governs apoptotic cell extrusion.Nature communications · 2021Article
- Actin-ring segment switching drives nonadhesive gap closure.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Reversible elastic phase field approach and application to cell monolayers.The European physical journal. E, Soft matter · 2020Article
- The Research Advance of Cell BridgesFrontiers in bioengineering and biotechnology · 2020Review
- Tissue Fluidity Promotes Epithelial Wound Healing.Nature physics · 2019Article
- Article
- Theoretical Analysis of Stress Distribution and Cell Polarization Surrounding a Model Wound.Biophysical journal · 2018Article
- Controlling Confinement and Topology to Study Collective Cell Behaviors.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Mechanics of epithelial tissues during gap closure.Current opinion in cell biology · 2016Review
- Modeling cell shape and dynamics on micropatterns.Cell adhesion & migration · 2016Article
- Dynamics of Cell Ensembles on Adhesive Micropatterns: Bridging the Gap between Single Cell Spreading and Collective Cell Migration.PLoS computational biology · 2016Article
- Cellular forces and matrix assembly coordinate fibrous tissue repair.Nature communications · 2016Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissue fusion eliminates physical voids in a tissue to form a continuous structure and is central to many processes in development and repair. Fusion events in vivo, particularly in embryonic development, often involve the purse-string contraction of a pluricellular actomyosin cable at the free edge. However, in vitro, adhesion of the cells to their substrate favors a closure mechanism mediated by lamellipodial protrusions, which has prevented a systematic study of the purse-string mechanism. Here, we show that monolayers can cover well-controlled mesoscopic nonadherent areas much larger than a cell size by purse-string closure and that active epithelial fluctuations are required for this process. We have formulated a simple stochastic model that includes purse-string contractility, tissue fluctuations, and effective friction to qualitatively and quantitatively account for the dynamics of closure. Our data suggest that, in vivo, tissue fusion adapts to the local environment by coordinating lamellipodial protrusions and purse-string contractions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.