ArticleMolecular biology and evolution2015
Synonymous Genetic Variation in Natural Isolates of Escherichia coli Does Not Predict Where Synonymous Substitutions Occur in a Long-Term Experiment.
Article in Molecular biology and evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 31 citations in OpenAlex.
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- Hotspots of genetic change in Yersinia pestis.Nature communications · 2025Article
- Core genes can have higher recombination rates than accessory genes within global microbial populations.eLife · 2022Article
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- Universal Constraints on Protein Evolution in the Long-Term Evolution Experiment with Escherichia coli.Genome biology and evolution · 2021Article
- Divergent Evolution of Mutation Rates and Biases in the Long-Term Evolution Experiment with Escherichia coli.Genome biology and evolution · 2020Article
- Comparative genomics of Staphylococcus aureus associated with subclinical and clinical bovine mastitis.PloS one · 2019Article
- Genetic Diversity inFrontiers in plant science · 2019Article
- The comparative population genetics ofPeerJ · 2019Article
- Identifying Drivers of Parallel Evolution: A Regression Model Approach.Genome biology and evolution · 2018Article
- Parallels between experimental and natural evolution of legume symbionts.Nature communications · 2018Article
- Analysis of bacterial genomes from an evolution experiment with horizontal gene transfer shows that recombination can sometimes overwhelm selection.PLoS genetics · 2018Article
- Core Genes Evolve Rapidly in the Long-Term Evolution Experiment with Escherichia coli.Genome biology and evolution · 2017Article
- The adaptation ofNPJ microgravity · 2017Article
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- Can the experimental evolution programme help us elucidate the genetic basis of adaptation in nature?Molecular ecology · 2016Review
- Gene flow in microbial communities could explain unexpected patterns of synonymous variation in theMobile genetic elementsArticle
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synonymous genetic differences vary by more than 20-fold among genes in natural isolates of Escherichia coli. One hypothesis to explain this heterogeneity is that genes with high levels of synonymous variation mutate at higher rates than genes with low synonymous variation. If so, then one would expect to observe similar mutational patterns in evolution experiments. In fact, however, the pattern of synonymous substitutions in a long-term evolution experiment with E. coli does not support this hypothesis. In particular, the extent of synonymous variation across genes in that experiment does not reflect the variation observed in natural isolates of E. coli. Instead, gene length alone predicts with high accuracy the prevalence of synonymous changes in the experimental populations. We hypothesize that patterns of synonymous variation in natural E. coli populations are instead caused by differences across genomic regions in their effective population size that, in turn, reflect different histories of recombination, horizontal gene transfer, selection, and population structure.
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