Evidence map›Paper›PMID 26199227›Full record

Observational studyJournal of the American Heart Association2015

Nonalcoholic Fatty Liver Disease Is Associated With QT Prolongation in the General Population.

Chi-Sheng Hung, Ping-Huei Tseng, Chia-Hung Tu, Chien-Chuan Chen, Wei-Chih Liao, Yi-Chia Lee, Han-Mo Chiu, Hung-Ju Lin, Yi-Lwun Ho, Wei-Shiung Yang and 2 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of the American Heart Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  4. Article
  5. Article
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  7. Sudden cardiac death associated with fatty liver disease.International journal of cardiology. Heart & vasculature · 2025
    Article
  8. Review
  9. [Metabolic-associated fatty liver disease (MAFLD): a multisystemic disease beyond the liver].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2025
    Review
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  15. Article
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  17. Nonalcoholic fatty liver disease and non-liver comorbidities.Clinical and molecular hepatology · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chi-Sheng HungDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan (C.S.H., P.H.T., C.H.T., C.C.C., W.C.L., Y.C.L., H.M.C., H.J.L., Y.L.H., W.S.Y., M.S.W., M.F.C.) Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan (C.S.H., P.H.T., C.H.T., W.S.Y.).
Ping-Huei TsengDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan (C.S.H., P.H.T., C.H.T., C.C.C., W.C.L., Y.C.L., H.M.C., H.J.L., Y.L.H., W.S.Y., M.S.W., M.F.C.) Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan (C.S.H., P.H.T., C.H.T., W.S.Y.).
Chia-Hung TuDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan (C.S.H., P.H.T., C.H.T., C.C.C., W.C.L., Y.C.L., H.M.C., H.J.L., Y.L.H., W.S.Y., M.S.W., M.F.C.) Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan (C.S.H., P.H.T., C.H.T., W.S.Y.).
Chien-Chuan ChenDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan (C.S.H., P.H.T., C.H.T., C.C.C., W.C.L., Y.C.L., H.M.C., H.J.L., Y.L.H., W.S.Y., M.S.W., M.F.C.).
Wei-Chih LiaoDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan (C.S.H., P.H.T., C.H.T., C.C.C., W.C.L., Y.C.L., H.M.C., H.J.L., Y.L.H., W.S.Y., M.S.W., M.F.C.).
Yi-Chia LeeDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan (C.S.H., P.H.T., C.H.T., C.C.C., W.C.L., Y.C.L., H.M.C., H.J.L., Y.L.H., W.S.Y., M.S.W., M.F.C.).
Han-Mo ChiuDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan (C.S.H., P.H.T., C.H.T., C.C.C., W.C.L., Y.C.L., H.M.C., H.J.L., Y.L.H., W.S.Y., M.S.W., M.F.C.).
Hung-Ju LinDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan (C.S.H., P.H.T., C.H.T., C.C.C., W.C.L., Y.C.L., H.M.C., H.J.L., Y.L.H., W.S.Y., M.S.W., M.F.C.).
Yi-Lwun HoDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan (C.S.H., P.H.T., C.H.T., C.C.C., W.C.L., Y.C.L., H.M.C., H.J.L., Y.L.H., W.S.Y., M.S.W., M.F.C.).
Wei-Shiung YangDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan (C.S.H., P.H.T., C.H.T., C.C.C., W.C.L., Y.C.L., H.M.C., H.J.L., Y.L.H., W.S.Y., M.S.W., M.F.C.) Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan (C.S.H., P.H.T., C.H.T., W.S.Y.).
Ming-Shiang WuDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan (C.S.H., P.H.T., C.H.T., C.C.C., W.C.L., Y.C.L., H.M.C., H.J.L., Y.L.H., W.S.Y., M.S.W., M.F.C.).
Ming-Fong ChenDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan (C.S.H., P.H.T., C.H.T., C.C.C., W.C.L., Y.C.L., H.M.C., H.J.L., Y.L.H., W.S.Y., M.S.W., M.F.C.).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNonalcoholic fatty liver disease (NAFLD) is independently associated with QT prolongation among patients with diabetes. It has not yet been determined whether this association remains valid in the general population. We designed an observational study to explore this association. METHODS AND

resultsWe conducted a cross-sectional analysis of 31 116 consecutive participants in our health management program. Heart rate-corrected QT (QTc) interval was derived from 12-lead electrocardiography and by Bazett's formula. NAFLD was diagnosed by abdominal ultrasonography and classified as none, mild, moderate, or severe, according to the ultrasonographic criteria. A multivariable linear regression model was fitted for the association between QTc interval and potential predictors (including demographic, anthropometric, biochemical factors, and comorbidities). Multivariable logistic regression analyses were fitted to assess the association between the severity of NAFLD and QTc prolongation, with the adjustment of significant predictors derived from multivariable linear regression. The mean QTc interval was 421.3 ms (SD 45.4 ms). In the multivariable linear regression analyses, mild, moderate, and severe NAFLD were associated with increases of 2.55, 6.59, and 12.13 ms, respectively, in QTc interval compared with no NAFLD (all P<0.001). In the multivariable logistic regression analyses, mild, moderate, and severe NAFLD were associated with an increased risk for QTc prolongation, with odds ratios of 1.11 (95% CI: 1.01 to 1.21, P<0.05), 1.61 (95% CI: 1.36 to 1.9, P<0.001), and 1.31 (95% CI: 1.16 to 2.24, P<0.01), respectively, in women, and 1.11 (95% CI: 1.01 to 1.21, P<0.05), 1.39 (95% CI: 1.22 to 1.59, P<0.001), and 1.87 (95% CI: 1.16 to 2.24, P<0.001), respectively, in men, after adjusting for predictors known to be associated with the QTc interval. The association remained significant among subgroups with or without diabetes.

conclusionsThe severity of NAFLD was associated with a higher risk for QTc prolongation in the general population with and without diabetes.

Indexed as

Action PotentialsAdultComorbidityCross-Sectional StudiesElectrocardiographyFemaleHeart Conduction SystemHeart RateHumansLinear ModelsLogistic ModelsLong QT SyndromeMaleMiddle AgedMultivariate AnalysisNon-alcoholic Fatty Liver Diseasediabetesgeneral populationnonalcoholic fatty liver diseaseQT prolongation

Identifiers

PMID26199227
PMCPMC4608068

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