ArticleBMC complementary and alternative medicine2015
Chemical profile and in vivo hypoglycemic effects of Syzygium jambos, Costus speciosus and Tapeinochilos ananassae plant extracts used as diabetes adjuvants in Puerto Rico.
Article in BMC complementary and alternative medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 38 citations in OpenAlex.
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- Prediction of α-Glucosidase Inhibitory Activity of LC-ESI-TQ-MS/MS-Identified Compounds fromPharmaceutics · 2022Article
- Traditional uses, pharmacological activities, and phytochemical constituents of the genusFood science & nutrition · 2022Review
- Inhibitory effects of Syzygium jambos extract on biomarkers of endothelial cell activation.BMC complementary medicine and therapies · 2022Article
- Nanoparticles ofMolecules (Basel, Switzerland) · 2022Article
- Review
- Complete chloroplast genome sequence of the rose apple,Mitochondrial DNA. Part B, Resources · 2020Article
- Biological Activities of Selected Plants and Detection of Bioactive Compounds fromMolecules (Basel, Switzerland) · 2020Article
- Antidiabetic Potential of Medicinal Plants and Their Active Components.Biomolecules · 2019Review
- Anticancer Potential of Syzygium Species: a Review.Plant foods for human nutrition (Dordrecht, Netherlands) · 2019Review
- Biochemical Activity and Hypoglycemic Effects ofBioMed research international · 2018Article
- Chemical composition and pharmacological activities of Pisum sativum.BMC complementary and alternative medicine · 2017Article
- Antinociceptive effect of methanol extract of Celosia cristata Linn. in mice.BMC complementary and alternative medicine · 2016Article
- α-glucosidase and glycation inhibitory effects of costus speciosus leaves.BMC complementary and alternative medicine · 2016Article
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundThe increasing numbers of people who use plant-based remedies as alternative or complementary medicine call for the validation of less known herbal formulations used to treat their ailments. Since Puerto Rico has the highest rate of Type 2 diabetes within all the states and territories of the United States, and Puerto Ricans commonly use plants as diabetes adjuvants, it is important to study the plants' physiological effects, and identify their bioactive compounds to understand their role in modulation of blood glucose levels. We present the phytochemical profiles and hypoglycemic effects of Tapeinochilus ananassae, Costus speciosus and Syzygium jambos.
methodsPhytochemicals in methanolic and aqueous extracts were analyzed by thin layer chromatography (TLC). Alkaloids (Bromocresol green, λ=470 nm), flavonoids (AlCl3, λ=415 nm), saponins (DNS, λ=760 nm), tannins (FeCl3/K4Fe(CN)6, λ=395 nm) and phenolics (Folin-Ciocalteau, λ=765 nm) were quantified. Male C57BLKS/J (db/db) and C57BL/J (ob/ob) genetically obese mice were orally gavaged with aqueous extracts of lyophilized plant decoctions for 10 wks.
resultsOur results show that T. ananassae had significantly greater amounts of flavonoids and tannins, while S. jambos showed the greatest concentration of phenolics and C. speciosus exhibited higher amounts of alkaloids. C57BLKS/J db/db treated with plant extracts show better glucose modulation when the extracts are administered in complement with an insulin injection. Finally, C57BL/J ob/ob mice on T. ananassae and S. jambos treatments show better blood glucose modulation over time.
conclusionThese results document for the first time the chemical profile of T. ananassae and provide evidence for a potential anti-diabetic efficacy of T. ananassae and S. jambos.
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