ReviewApplied microbiology and biotechnology2015
Macroscopic modeling of mammalian cell growth and metabolism.
Review in Applied microbiology and biotechnology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Comparing kinetic versus stoichiometric priorities in hybrid models of CHO metabolism.NPJ systems biology and applications · 2026Article
- mAb production kinetics in CHO batch culture: exploring extracellular and intracellular dynamics.Frontiers in bioengineering and biotechnology · 2025Article
- Challenges of Spatially Resolved Metabolism in Cancer Research.Metabolites · 2024Review
- A perspective-driven and technical evaluation of machine learning in bioreactor scale-up: A case-study for potential model developments.Engineering in life sciences · 2024Article
- Integration Approaches to Model Bioreactor Hydrodynamics and Cellular Kinetics for Advancing Bioprocess Optimisation.Bioengineering (Basel, Switzerland) · 2024Review
- Integrated Experimental and Mathematical Exploration of Modular Tissue Cultures for Developmental Engineering.International journal of molecular sciences · 2024Article
- Inference of metabolic fluxes in nutrient-limited continuous cultures: A Maximum Entropy approach with the minimum information.iScience · 2022Article
- White paper on high-throughput process development for integrated continuous biomanufacturing.Biotechnology and bioengineering · 2021Review
- Digital Twins in Biomanufacturing.Advances in biochemical engineering/biotechnology · 2021Article
- A unifying modelling formalism for the integration of stoichiometric and kinetic models.Journal of the Royal Society, Interface · 2020Article
- Early integration of Design of Experiment (DOE) and multivariate statistics identifies feeding regimens suitable for CHO cell line development and screening.Cytotechnology · 2019Article
- Novel column generation-based optimization approach for poly-pathway kinetic model applied to CHO cell culture.Metabolic engineering communications · 2019Article
- Process Analytical Technology for Advanced Process Control in Biologics Manufacturing with the Aid of Macroscopic Kinetic Modeling.Bioengineering (Basel, Switzerland) · 2018Article
- Characterizing steady states of genome-scale metabolic networks in continuous cell cultures.PLoS computational biology · 2017Article
- Segmented linear modeling of CHO fed-batch culture and its application to large scale production.Biotechnology and bioengineering · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We review major modeling strategies and methods to understand and simulate the macroscopic behavior of mammalian cells. These strategies comprise two important steps: the first step is to identify stoichiometric relationships for the cultured cells connecting the extracellular inputs and outputs. In a second step, macroscopic kinetic models are introduced. These relationships together with bioreactor and metabolite balances provide a complete description of a system in the form of a set of differential equations. These can be used for the simulation of cell culture performance and further for optimization of production.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.