ArticleScientific reports2015
Calcium Spikes in Epithelium: study on Drosophila early embryos.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Nematic cell alignment directs calcium waves in an epithelial monolayer.Biophysical journal · 2026Article
- Nematic cell alignment directs calcium waves.bioRxiv : the preprint server for biology · 2025Article
- Calcium signaling is required for anterior patterning in the mouse embryo.PLoS biology · 2025Article
- Regulation of long-range BMP gradients and embryonic polarity by propagation of local calcium-firing activity.Nature communications · 2024Article
- Deciphering the Calcium Code: A Review of Calcium Activity Analysis Methods Employed to Identify Meaningful Activity in Early Neural Development.Biomolecules · 2024Review
- The Gr64 cluster of gustatory receptors promotes survival and proteostasis of epithelial cells in Drosophila.PLoS biology · 2022Article
- Lighting Up CaCells · 2021Review
- Calcium Activity Dynamics Correlate with Neuronal Phenotype at a Single Cell Level and in a Threshold-Dependent Manner.International journal of molecular sciences · 2019Article
- Decoding Calcium Signaling Dynamics during Drosophila Wing Disc Development.Biophysical journal · 2019Article
- Calcium Signaling in Vertebrate Development and Its Role in Disease.International journal of molecular sciences · 2018Review
- A Genetically Encoded Biosensor Strategy for Quantifying Non-muscle Myosin II Phosphorylation Dynamics in Living Cells and Organisms.Cell reports · 2018Article
- Calcium as a signal integrator in developing epithelial tissues.Physical biology · 2018Review
- Intracellular calcium signal at the leading edge regulates mesodermal sheet migration during Xenopus gastrulation.Scientific reports · 2018Article
- Calcium spikes, waves and oscillations in a large, patterned epithelial tissue.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcium ion acts in nearly every aspect of cellular life. The versatility and specificity required for such a ubiquitous role is ensured by the spatio-temporal dynamics of calcium concentration variations. While calcium signal dynamics has been extensively studied in cell cultures and adult tissues, little is known about calcium activity during early tissue morphogenesis. We monitored intracellular calcium concentration in Drosophila gastrula and revealed single cell calcium spikes that were short-lived, rare and showed strong variability among embryos. We quantitatively described the spatio-temporal dynamics of these spikes and analyzed their potential origins and nature by introducing physical and chemical perturbations. Our data highlight the inter- and intra-tissue variability of calcium activity during tissue morphogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.