ArticleDevelopment and psychopathology2016
Childhood maltreatment is associated with altered frontolimbic neurobiological activity during wakefulness in adulthood.
Article in Development and psychopathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Childhood maltreatment and the risk of eating disorders: a meta-analysis of observational studies.Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2025Pooled it
- Oligodendrocytes matter: a review of animal studies on early adversity.Journal of neural transmission (Vienna, Austria : 1996) · 2023Review
- Distinctively different human neurobiological responses after trauma exposure and implications for posttraumatic stress disorder subtyping.Molecular psychiatry · 2023Article
- Methylation and expression of glucocorticoid receptor exon-1 variants and FKBP5 in teenage suicide-completers.Translational psychiatry · 2023Article
- The cerebellum and psychological trauma: A systematic review of neuroimaging studies.Neurobiology of stress · 2022Review
- Longitudinal hippocampal circuit change differentiates persistence and remission of pediatric posttraumatic stress disorder.Depression and anxiety · 2022Article
- Adverse childhood experiences and household food insecurity among children aged 0-5 years in the USA.Public health nutrition · 2021Article
- Article
- Early Life Adversity as a Moderator of Symptom Change following Selective Serotonin Reuptake Inhibitors and Cognitive Behavioral Therapy.Cognitive therapy and research · 2021Article
- Early-life stress impairs postnatal oligodendrogenesis and adult emotional behaviour through activity-dependent mechanisms.Molecular psychiatry · 2020Article
- Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation.Frontiers in psychiatry · 2019Review
- Cognitive control and network disruption in remitted depression: a correlate of childhood adversity.Social cognitive and affective neuroscience · 2018Article
- Neuroinflammation, Early-Life Adversity, and Brain Development.Harvard review of psychiatryReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Childhood maltreatment can disturb brain development and subsequently lead to adverse socioemotional and mental health problems across the life span. The long-term association between childhood maltreatment and resting-wake brain activity during adulthood is unknown and was examined in the current study. Forty-one medically stable and medication-free military veterans (M = 29.31 ± 6.01 years, 78% male) completed a battery of clinical assessments and had [18F]-fluorodeoxyglucose positron emission tomography neuroimaging scans during quiet wakefulness. After statistically adjusting for later-life trauma and mental health problems, childhood maltreatment was negatively associated with brain activity within a priori defined regions that included the left orbital frontal cortex and left hippocampus. Childhood maltreatment was significantly associated with increased and decreased brain activity within six additional whole-brain clusters that included the frontal, parietal-temporal, cerebellar, limbic, and midbrain regions. Childhood maltreatment is associated with altered neural activity in adulthood within regions that are involved in executive functioning and cognitive control, socioemotional processes, autonomic functions, and sleep/wake regulation. This study provides support for taking a life span developmental approach to understanding the effects of early-life maltreatment on later-life neurobiology, socioemotional functioning, and mental health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.