ArticleVeterinary research2015
A combinational approach of multilocus sequence typing and other molecular typing methods in unravelling the epidemiology of Erysipelothrix rhusiopathiae strains from poultry and mammals.
Article in Veterinary research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed.
- An ancient Erysipelothrix rhusiopathiae genome recovered from 1400-year-old human remains in the Northern Caucasus.Scientific reports · 2026Article
- Oxford Nanopore Sequencing of Clinical DNA for Identification and Comparative Genomic Analysis of Erysipelothrix piscisicarius.Transboundary and emerging diseases · 2026Article
- Serotypes, Antimicrobial Susceptibility, and Potential Mechanisms of Resistance Gene Transfer inInternational journal of molecular sciences · 2024Article
- Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2024Article
- Integrative and Conjugative Elements and Prophage DNA as Carriers of Resistance Genes inInternational journal of molecular sciences · 2024Article
- Serotypes, Antibiotic Susceptibility, Genotypic Virulence Profiles and SpaA Variants ofPathogens (Basel, Switzerland) · 2023Article
- Population Structure and Genomic Characteristics of AustralianMicroorganisms · 2023Article
- Pathology, microbiology, and genetic diversity associated withFrontiers in microbiology · 2023Article
- The Distribution Characteristics of Aerosol Bacteria in Different Types of Pig Houses.Animals : an open access journal from MDPI · 2022Article
- Pathological and Genomic Findings ofFrontiers in veterinary science · 2022Article
- Screening immune adjuvants for an inactivated vaccine againstFrontiers in veterinary science · 2022Article
- HumanFrontiers in cellular and infection microbiology · 2022Article
- Characterization ofMicroorganisms · 2021Article
- Comparative genomics of a novel clade shed light on the evolution of the genus Erysipelothrix and characterise an emerging species.Scientific reports · 2021Article
- First Report of Genetic Variability ofPathogens (Basel, Switzerland) · 2021Article
- Comparative genome analysis ofMicrobial genomics · 2020Article
- Comparative Genome Analysis of a PathogenicVeterinary sciences · 2020Article
- Development of a Multiplex PCR-Based Assay for Rapid Serotyping ofJournal of clinical microbiology · 2020Article
- Review
- Genomic and Immunogenic Protein Diversity ofFrontiers in microbiology · 2020Article
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6 authors.
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Abstract
Erysipelothrix rhusiopathiae infections re-emerged as a matter of great concern particularly in the poultry industry. In contrast to porcine isolates, molecular epidemiological traits of avian E. rhusiopathiae isolates are less well known. Thus, we aimed to (i) develop a multilocus sequence typing (MLST) scheme for E. rhusiopathiae, (ii) study the congruence of strain grouping based on pulsed-field gel electrophoresis (PFGE) and MLST, (iii) determine the diversity of the dominant immunogenic protein SpaA, and (iv) examine the distribution of genes putatively linked with virulence among field isolates from poultry (120), swine (24) and other hosts (21), including humans (3). Using seven housekeeping genes for MLST analysis we determined 72 sequence types (STs) among 165 isolates. This indicated an overall high diversity, though 34.5% of all isolates belonged to a single predominant ST-complex, STC9, which grouped strains from birds and mammals, including humans, together. PFGE revealed 58 different clusters and congruence with the sequence-based MLST-method was not common. Based on polymorphisms in the N-terminal hyper-variable region of SpaA the isolates were classified into five groups, which followed the phylogenetic background of the strains. More than 90% of the isolates harboured all 16 putative virulence genes tested and only intI, encoding an internalin-like protein, showed infrequent distribution. MLST data determined E. rhusiopathiae as weakly clonal species with limited host specificity. A common evolutionary origin of isolates as well as shared SpaA variants and virulence genotypes obtained from avian and mammalian hosts indicates common reservoirs, pathogenic pathways and immunogenic properties of the pathogen.
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