Evidence map›Paper›PMID 26198438›Full record

ArticleNeurocritical care2016

Hyperacute Vasospasm After Aneurysmal Subarachnoid Hemorrhage.

B Bar, L MacKenzie, R W Hurst, R Grant, J Weigele, P K Bhalla, M A Kumar, M F Stiefel, J M Levine

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Article in Neurocritical care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Haemorrhage, hypercoagulability and ischaemia: Evolution of brain injury after aneurysmal subarachnoid haemorrhage.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
  2. Article
  3. Article
  4. Observational
  5. Cerebral Microdialysis in Neurocritical Care.Current neurology and neuroscience reports · 2018
    Review
  6. The rise of soluble platelet-derived growth factor receptor β in CSF early after subarachnoid hemorrhage correlates with cerebral vasospasm.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

B BarDepartment of Neurosurgery, Thomas Jefferson University, Philadelphia, PA, USA.
L MacKenzieDepartment of Neurology, Abington Memorial Hospital, Abington, PA, USA.
R W HurstDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
R GrantDepartment of Neurosurgery, Yale School of Medicine, New Haven, CT, USA.
J WeigeleDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
P K BhallaDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
M A KumarDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
M F StiefelDepartment of Neurosurgery, Westchester Medical Center, Valhalla, NY, USA.
J M LevineDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, 19104, USA. joshua.levine@uphs.upenn.edu.
University of Pennsylvania · USAbington Memorial Hospital · USThomas Jefferson University · USWestchester Medical Center · USYale University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCerebral vasospasm after aneurysmal subarachnoid hemorrhage typically occurs 3-14 days after aneurysm rupture. We describe a series of patients who developed vasospasm within minutes of aneurysm rupture. This phenomenon, which we term, "hyperacute vasospasm," has been reported in animal models of SAH, but hitherto has been poorly described in humans.

methodsEleven patients were identified from an institutional registry who had aneurysmal rupture during catheter cerebral angiography between 1997 and 2009. We quantified the degree of vasoconstriction using vascular diameter index (VDI). The change in VDI (delta VDI or DVDI) was calculated by determining the difference in VDI before and after the procedure. We also examined the relationship between hyperacute vasospasm and delayed cerebral ischemia.

resultsTen of eleven (91%) patients with intraoperative aneurysm rupture had cerebral vasoconstriction within minutes of intra-procedural aneurysmal rupture. Six of eleven patients (55%) with hyperacute vasospasm developed delayed cerebral infarction.

conclusionsHyperacute vasospasm is likely common in patients with intraoperative aneurysm rupture and may be an unrecognized element of the natural history of aneurysmal subarachnoid hemorrhage. In this limited series, there was an association between hyperacute vasospasm and delayed cerebral infarction.

Indexed as

Intraoperative ComplicationsRegistriesAcute DiseaseAdultAgedAneurysm, RupturedCerebral AngiographyFemaleHumansIntracranial AneurysmMaleMiddle AgedRetrospective StudiesSubarachnoid HemorrhageVasospasm, IntracranialAneurysm ruptureCerebral vasospasmSubarachnoid hemorrhage

Identifiers

PMID26198438
OpenAlexW2167852233

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.