SynthesisNature communications2015
Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients.
Erratum issuedOpen access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 5 pooled it
3.6field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 5 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Pooled it
- A Meta-analysis of Multiple Myeloma Risk Regions in African and European Ancestry Populations Identifies Putatively Functional Loci.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2016Pooled it
- Multiple myeloma and family history of lymphohaematopoietic cancers: Results from the International Multiple Myeloma Consortium.British journal of haematology · 2016Pooled it
- Pooled it
- Genome-wide association study identifies variation at 6q25.1 associated with survival in multiple myeloma.Nature communications · 2016Pooled it
- Genetic architecture of multiple myeloma: From somatic alterations to germline susceptibility and clinical implications.Translational oncology · 2026Review
- A Rare Variant inCancers · 2023Article
- High-throughput electron tomography identifies centriole over-elongation as an early event in plasma cell disorders.Leukemia · 2023Article
- High-Risk Pedigree Study IdentifiesCancers · 2023Article
- Strategies to investigate and mitigate collider bias in genetic and Mendelian randomisation studies of disease progression.PLoS genetics · 2023Review
- Monoclonal Gammopathies and the Bone Marrow Microenvironment: From Bench to Bedside and Then Back Again.Hematology reports · 2023Review
- The Relationship ofJournal of clinical medicine · 2021Article
- Genetic determinants of multiple myeloma risk within the Wnt/beta-catenin signaling pathway.Cancer epidemiology · 2021Article
- Expression quantitative trait loci of genes predicting outcome are associated with survival of multiple myeloma patients.International journal of cancer · 2021Article
- An intronic variant in the CELF4 gene is associated with risk for colorectal cancer.Cancer epidemiology · 2021Article
- Genetically determined telomere length and multiple myeloma risk and outcome.Blood cancer journal · 2021Article
- Lack of association of CD44-rs353630 and CHI3L2-rs684559 with pancreatic ductal adenocarcinoma survival.Scientific reports · 2021Article
- Concordance in survival among first-degree relatives diagnosed with indolent lymphoid malignancies including chronic lymphocytic leukemia.European journal of haematology · 2020Article
- Coinherited genetics of multiple myeloma and its precursor, monoclonal gammopathy of undetermined significance.Blood advances · 2020Article
- Sequence variation at the MTHFD1L-AKAP12 and FOPNL loci does not influence multiple myeloma survival in Sweden.Blood cancer journal · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
38 authors at 15 institutions in 7 countries.
Elad Ziv *Department of Medicine, Division of General Internal Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California.
Eric Dean *Sutter Medical Center of Santa Rosa, Santa Rosa, California.
Donglei HuDepartment of Medicine, Division of General Internal Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California.
Alessandro MartinoGenomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Daniel SerieDivision of Biomedical Statistics and Informatics. Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL, USA.
Karen CurtinDepartment of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
Daniele CampaGenomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Blake AftabDepartment of Medicine, Division of Hematology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California.
Paige BracciDepartment of Epidemiology and Biostatistics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California.
Gabriele BudaDepartment of Oncology, Transplants and Advanced Technologies, Section of Hematology, Pisa University Hospital, Pisa, Italy.
Yi ZhaoDepartment of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
Jennifer Caswell-JinDepartment of Medicine, Division of General Internal Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California.
Robert DiasioDepartment of Molecular Pharmacology and Experimental Therapeutics, College of Medicine, Mayo Clinic, Rochester, MN.
Charles DumontetINSERM UMR 1052 / CNRS 5286, Laboratoire de Cytologie Analytique, Faculté de Médecine Rockefeller, Université Claude Bernard Lyon I, Lyon, France.
Marek DudzińskiDepartment of Hematology, Rzeszow Regional Hospital, Rzeszow, Poland.
Laura FejermanDepartment of Medicine, Division of General Internal Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California.
Alexandra GreenbergCenter for Translational Science Activities, Mayo Clinic, Rochester, MN, USA Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, USA.
Scott HuntsmanDepartment of Medicine, Division of General Internal Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California.
Krzysztof JamroziakDepartment of Hematology, Medical University of Lodz, Lodz, Poland.
Artur JurczyszynDepartment of Hematology, Cracow University Hospital, Cracow, Poland.
Shaji KumarDivision of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Djordje AtanackovicDepartment of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
Martha GlennDepartment of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
Lisa A Cannon-AlbrightDepartment of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
Brandt JonesDepartment of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
Adam LeeDepartment of Molecular Pharmacology and Experimental Therapeutics, College of Medicine, Mayo Clinic, Rochester, MN.
Herlander MarquesLife and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal.
Thomas MartinDepartment of Medicine, Division of Hematology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California.
Joaquin Martinez-LopezHematology Service, CRIS facility for Hematological research, Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid, Spain.
Vincent RajkumarDivision of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Juan SainzGenomic Oncology Area, GENYO, Centre for Genomics and Oncological Research: Pfizer / University of Granada / Andalusian Regional Government, Granada, Spain; Hematology department, Virgen de las Nieves University Hospital, Granada, Spain.
Annette Juul VangstedDepartment of Hematology, Righospitalet and Roskilde Hospital, Copenhagen University, Denmark.
Marzena WątekDepartment of Hematology, Holycross Cancer Center, Kielce, Poland.
Jeffrey WolfDepartment of Medicine, Division of Hematology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California.
Susan SlagerDivision of Biomedical Statistics and Informatics. Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA.
Nicola J CampDepartment of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
Federico CanzianGenomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Celine VachonDivision of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine Rochester, MN, USA.
University of California, San Francisco · USMayo Clinic · USUniversity of Utah · USGerman Cancer Research Center · DECracow University of Technology · PLHoly Cross University · PLHospital Universitario 12 De Octubre · ESHospital Universitario Virgen de las Nieves · ESJacksonville College · USMedical University of Lodz · PLRoskilde Sygehus · DKSutter Medical Center · USUniversité Claude Bernard Lyon 1 · FRUniversity of Minho · PTUniversity of Rzeszów · PL
Funding
UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 1986 to 2026
$72.6MGENETIC EPIDEMIOLOGY OF CHRONIC LYMPHOCYTIC LEUKEMIAR01CA134674 · NCI · UNIVERSITY OF UTAH · PI CAMP, NICOLA J. · 2010 to 2016
$3.8MGenetics of mammographic density and breast cancer risk in LatinasK24CA169004 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZIV, ELAD · 2012 to 2021
$1.8MInfluence of germ line genetic variation on myeloma progression and survivalR21CA191896 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VACHON, CELINE M, ZIV, ELAD · 2015 to 2016
$407kShared Genomic Segment Analysis for Localizing Multiple Myeloma GenesR21CA152336 · NCI · UNIVERSITY OF UTAH · PI CAMP, NICOLA J. · 2010 to 2011
$353kNCI NIH HHS CA134674NCI NIH HHS CA152336NCI NIH HHS HHSN261201000026CNCI NIH HHS K24 CA169004NCI NIH HHS P30 CA042014NCI NIH HHS P30CA42014NCI NIH HHS R01 CA134674NCI NIH HHS R21 CA152336NCI NIH HHS R21 CA191896
Abstract
Here we perform the first genome-wide association study (GWAS) of multiple myeloma (MM) survival. In a meta-analysis of 306 MM patients treated at UCSF and 239 patients treated at the Mayo clinic, we find a significant association between SNPs near the gene FOPNL on chromosome 16p13 and survival (rs72773978; P=6 × 10(-10)). Patients with the minor allele are at increased risk for mortality (HR: 2.65; 95% CI: 1.94-3.58) relative to patients homozygous for the major allele. We replicate the association in the IMMEnSE cohort including 772 patients, and a University of Utah cohort including 318 patients (rs72773978 P=0.044). Using publicly available data, we find that the minor allele was associated with increased expression of FOPNL and increased expression of FOPNL was associated with higher expression of centrosomal genes and with shorter survival. Polymorphisms at the FOPNL locus are associated with survival among MM patients.
Indexed as
Chromosomes, Human, Pair 16Genome-Wide Association StudyHumansKaplan-Meier EstimateMultiple MyelomaPolymorphism, Single Nucleotide
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.