ArticleJournal of the American Medical Informatics Association : JAMIA2015
SMART on FHIR Genomics: facilitating standardized clinico-genomic apps.
Article in Journal of the American Medical Informatics Association : JAMIA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03911687 (Communicating Narrative Concerns Entered by RNs), which is not on this map. Cited by 62 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Communicating Narrative Concerns Entered by RNs (CONCERN) Clinical Decision Support (CDS) System
Who cites it
62 citing papers in PubMed.
- Model Context Protocol: The unexpected catalyst of a bioinformatics interoperability revolution.PLoS computational biology · 2026Article
- Assessment of the adequacy of the Fast Healthcare Interoperability Resources (FHIR) Genomics standard for the representation of somatic testing reports.JAMIA open · 2026Article
- Genomics on FHIR - a feasibility study to support a National Strategy for Genomic Medicine.NPJ genomic medicine · 2025Article
- Genomics and multiomics in the age of precision medicine.Pediatric research · 2025Review
- Opportunities and challenges for biomarker discovery using electronic health record data.Trends in molecular medicine · 2023Review
- Machine Learning-Enabled Clinical Information Systems Using Fast Healthcare Interoperability Resources Data Standards: Scoping Review.JMIR medical informatics · 2023Article
- Ontologizing health systems data at scale: making translational discovery a reality.NPJ digital medicine · 2023Article
- Introducing HL7 FHIR Genomics Operations: a developer-friendly approach to genomics-EHR integration.Journal of the American Medical Informatics Association : JAMIA · 2023Article
- A cloud-based pipeline for analysis of FHIR and long-read data.Bioinformatics advances · 2023Article
- MatchMiner: an open-source platform for cancer precision medicine.NPJ precision oncology · 2022Article
- HL7 FHIR-based tools and initiatives to support clinical research: a scoping review.Journal of the American Medical Informatics Association : JAMIA · 2022Article
- Research data warehouse best practices: catalyzing national data sharing through informatics innovation.Journal of the American Medical Informatics Association : JAMIA · 2022Article
- CASIDE: A data model for interoperable cancer survivorship information based on FHIR.Journal of biomedical informatics · 2021Article
- Interoperable genetic lab test reports: mapping key data elements to HL7 FHIR specifications and professional reporting guidelines.Journal of the American Medical Informatics Association : JAMIA · 2021Article
- New Standards for Clinical Decision Support: A Survey of The State of Implementation.Yearbook of medical informatics · 2021Review
- Human-centered development of an electronic health record-embedded, interactive information visualization in the emergency department using fast healthcare interoperability resources.Journal of the American Medical Informatics Association : JAMIA · 2021Article
- Genomic considerations for FHIR®; eMERGE implementation lessons.Journal of biomedical informatics · 2021Article
- Enabling Precision Medicine in Cancer Care Through a Molecular Data Warehouse: The Moffitt Experience.JCO clinical cancer informatics · 2021Article
- Fast Healthcare Interoperability Resources (FHIR)-Based Quality Information Exchange for Clinical Next-Generation Sequencing Genomic Testing: Implementation Study.Journal of medical Internet research · 2021Article
- vcf2fhir: a utility to convert VCF files into HL7 FHIR format for genomics-EHR integration.BMC bioinformatics · 2021Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSupporting clinical decision support for personalized medicine will require linking genome and phenome variants to a patient's electronic health record (EHR), at times on a vast scale. Clinico-genomic data standards will be needed to unify how genomic variant data are accessed from different sequencing systems.
methodsA specification for the basis of a clinic-genomic standard, building upon the current Health Level Seven International Fast Healthcare Interoperability Resources (FHIR®) standard, was developed. An FHIR application protocol interface (API) layer was attached to proprietary sequencing platforms and EHRs in order to expose gene variant data for presentation to the end-user. Three representative apps based on the SMART platform were built to test end-to-end feasibility, including integration of genomic and clinical data.
resultsSuccessful design, deployment, and use of the API was demonstrated and adopted by HL7 Clinical Genomics Workgroup. Feasibility was shown through development of three apps by various types of users with background levels and locations.
conclusionThis prototyping work suggests that an entirely data (and web) standards-based approach could prove both effective and efficient for advancing personalized medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.