ArticlePlant physiology2015
Calcineurin B-Like Protein-Interacting Protein Kinase CIPK21 Regulates Osmotic and Salt Stress Responses in Arabidopsis.
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Article in Plant physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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69 citing papers in PubMed, 160 citations in OpenAlex.
- LjCIPK1: a CBL-interacting protein kinase fromFrontiers in plant science · 2026Article
- The CtrCBL1/CtrCIPK6 Complex of Citrus Phosphorylates CtrBBX32 to Regulate CtrSTP1-Mediated Sugar Accumulation and Cold Tolerance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Transcriptomic profiling of Arabidopsis Thaliana responses to Stutzerimonas stutzeri, chlorella vulgaris, and mixed consortium inoculation under salt stress.Plant molecular biology · 2025Article
- The KH-domain genes FLK and HOS5 integrate flowering and stress responses in Arabidopsis thaliana.Journal of experimental botany · 2025Article
- Evolution and functional characterization of Populus salt stress-responsive calcineurin B-like protein-interacting protein kinases.Plant cell reports · 2024Article
- Genomic survey and evolution analysis of calcium-dependent protein kinases in plants and their stress-responsive patterns in populus.BMC genomics · 2024Article
- Transcriptome-wide Identification of Nine Tandem Repeat Protein Families in Roselle (Tropical life sciences research · 2024Article
- Understanding the salt overly sensitive pathway in Prunus: Identification and characterization of NHX, CIPK, and CBL genes.The plant genome · 2024Article
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- The Roles of Calcineurin B-like Proteins in Plants under Salt Stress.International journal of molecular sciences · 2023Review
- The Morphological Parameters and Cytosolic pH of Cells of Root Zones in Tobacco Plants (Plants (Basel, Switzerland) · 2023Article
- Plant lysin motif extracellular proteins are required for arbuscular mycorrhizal symbiosis.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Phosphatidic acid-regulated SOS2 controls sodium and potassium homeostasis in Arabidopsis under salt stress.The EMBO journal · 2023Article
- Cold-induced calreticulin OsCRT3 conformational changes promote OsCIPK7 binding and temperature sensing in rice.The EMBO journal · 2023Article
- Comprehensive identification and expression analyses of the SnRK gene family in Casuarina equisetifolia in response to salt stress.BMC plant biology · 2022Article
- Evolution of the CBL and CIPK gene families in Medicago: genome-wide characterization, pervasive duplication, and expression pattern under salt and drought stress.BMC plant biology · 2022Article
- Insights into the molecular aspects of salt stress tolerance in mycorrhizal plants.World journal of microbiology & biotechnology · 2022Review
- Molecular and expression analysis indicate the role of CBL interacting protein kinases (CIPKs) in abiotic stress signaling and development in chickpea.Scientific reports · 2022Article
- A calmodulin-like protein (CML10) interacts with cytosolic enzymes GSTU8 and FBA6 to regulate cold tolerance.Plant physiology · 2022Article
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13 authors at 5 institutions in 3 countries.
Girdhar K PandeyDepartment of Plant Molecular Biology, University of Delhi South Campus, New Delhi 110021, India (G.K.P., P.K., A.S., A.P., A.K.Y., I.T., S.K.S.);Molekulargenetik und Zellbiologie der Pflanzen Institut für Biologie und Biotechnologie der Pflanzen, Universität Münster, 48149 Muenster, Germany (L.S., J.K.);Department of Molecular Breeding, National Academy of Agricultural Science, Jeonju 560-500, Korea (B.-G.K.);Department of Plant and Microbial Biology, University of California, Berkeley, California 94720 (B.-G.K., S.-C.L., Y.-H.C., S.L.);Department of Life Science, Chung-Ang University, HeukSeok-Dong, Dongjak-Gu, Seoul 156-756, Korea (S.-C.L.); andDepartment of Bio-Environmental Science, Sunchon National University, Suncheon, Jeonnam 540-742, Korea (Y.-H.C.) gkpandey@south.du.ac.in sluan@berkeley.edu.
Poonam KanwarDepartment of Plant Molecular Biology, University of Delhi South Campus, New Delhi 110021, India (G.K.P., P.K., A.S., A.P., A.K.Y., I.T., S.K.S.);Molekulargenetik und Zellbiologie der Pflanzen Institut für Biologie und Biotechnologie der Pflanzen, Universität Münster, 48149 Muenster, Germany (L.S., J.K.);Department of Molecular Breeding, National Academy of Agricultural Science, Jeonju 560-500, Korea (B.-G.K.);Department of Plant and Microbial Biology, University of California, Berkeley, California 94720 (B.-G.K., S.-C.L., Y.-H.C., S.L.);Department of Life Science, Chung-Ang University, HeukSeok-Dong, Dongjak-Gu, Seoul 156-756, Korea (S.-C.L.); andDepartment of Bio-Environmental Science, Sunchon National University, Suncheon, Jeonnam 540-742, Korea (Y.-H.C.).
Amarjeet SinghDepartment of Plant Molecular Biology, University of Delhi South Campus, New Delhi 110021, India (G.K.P., P.K., A.S., A.P., A.K.Y., I.T., S.K.S.);Molekulargenetik und Zellbiologie der Pflanzen Institut für Biologie und Biotechnologie der Pflanzen, Universität Münster, 48149 Muenster, Germany (L.S., J.K.);Department of Molecular Breeding, National Academy of Agricultural Science, Jeonju 560-500, Korea (B.-G.K.);Department of Plant and Microbial Biology, University of California, Berkeley, California 94720 (B.-G.K., S.-C.L., Y.-H.C., S.L.);Department of Life Science, Chung-Ang University, HeukSeok-Dong, Dongjak-Gu, Seoul 156-756, Korea (S.-C.L.); andDepartment of Bio-Environmental Science, Sunchon National University, Suncheon, Jeonnam 540-742, Korea (Y.-H.C.).
Leonie SteinhorstDepartment of Plant Molecular Biology, University of Delhi South Campus, New Delhi 110021, India (G.K.P., P.K., A.S., A.P., A.K.Y., I.T., S.K.S.);Molekulargenetik und Zellbiologie der Pflanzen Institut für Biologie und Biotechnologie der Pflanzen, Universität Münster, 48149 Muenster, Germany (L.S., J.K.);Department of Molecular Breeding, National Academy of Agricultural Science, Jeonju 560-500, Korea (B.-G.K.);Department of Plant and Microbial Biology, University of California, Berkeley, California 94720 (B.-G.K., S.-C.L., Y.-H.C., S.L.);Department of Life Science, Chung-Ang University, HeukSeok-Dong, Dongjak-Gu, Seoul 156-756, Korea (S.-C.L.); andDepartment of Bio-Environmental Science, Sunchon National University, Suncheon, Jeonnam 540-742, Korea (Y.-H.C.).
Amita PandeyDepartment of Plant Molecular Biology, University of Delhi South Campus, New Delhi 110021, India (G.K.P., P.K., A.S., A.P., A.K.Y., I.T., S.K.S.);Molekulargenetik und Zellbiologie der Pflanzen Institut für Biologie und Biotechnologie der Pflanzen, Universität Münster, 48149 Muenster, Germany (L.S., J.K.);Department of Molecular Breeding, National Academy of Agricultural Science, Jeonju 560-500, Korea (B.-G.K.);Department of Plant and Microbial Biology, University of California, Berkeley, California 94720 (B.-G.K., S.-C.L., Y.-H.C., S.L.);Department of Life Science, Chung-Ang University, HeukSeok-Dong, Dongjak-Gu, Seoul 156-756, Korea (S.-C.L.); andDepartment of Bio-Environmental Science, Sunchon National University, Suncheon, Jeonnam 540-742, Korea (Y.-H.C.).
Akhlilesh K YadavDepartment of Plant Molecular Biology, University of Delhi South Campus, New Delhi 110021, India (G.K.P., P.K., A.S., A.P., A.K.Y., I.T., S.K.S.);Molekulargenetik und Zellbiologie der Pflanzen Institut für Biologie und Biotechnologie der Pflanzen, Universität Münster, 48149 Muenster, Germany (L.S., J.K.);Department of Molecular Breeding, National Academy of Agricultural Science, Jeonju 560-500, Korea (B.-G.K.);Department of Plant and Microbial Biology, University of California, Berkeley, California 94720 (B.-G.K., S.-C.L., Y.-H.C., S.L.);Department of Life Science, Chung-Ang University, HeukSeok-Dong, Dongjak-Gu, Seoul 156-756, Korea (S.-C.L.); andDepartment of Bio-Environmental Science, Sunchon National University, Suncheon, Jeonnam 540-742, Korea (Y.-H.C.).
Indu TokasDepartment of Plant Molecular Biology, University of Delhi South Campus, New Delhi 110021, India (G.K.P., P.K., A.S., A.P., A.K.Y., I.T., S.K.S.);Molekulargenetik und Zellbiologie der Pflanzen Institut für Biologie und Biotechnologie der Pflanzen, Universität Münster, 48149 Muenster, Germany (L.S., J.K.);Department of Molecular Breeding, National Academy of Agricultural Science, Jeonju 560-500, Korea (B.-G.K.);Department of Plant and Microbial Biology, University of California, Berkeley, California 94720 (B.-G.K., S.-C.L., Y.-H.C., S.L.);Department of Life Science, Chung-Ang University, HeukSeok-Dong, Dongjak-Gu, Seoul 156-756, Korea (S.-C.L.); andDepartment of Bio-Environmental Science, Sunchon National University, Suncheon, Jeonnam 540-742, Korea (Y.-H.C.).
Sibaji K SanyalDepartment of Plant Molecular Biology, University of Delhi South Campus, New Delhi 110021, India (G.K.P., P.K., A.S., A.P., A.K.Y., I.T., S.K.S.);Molekulargenetik und Zellbiologie der Pflanzen Institut für Biologie und Biotechnologie der Pflanzen, Universität Münster, 48149 Muenster, Germany (L.S., J.K.);Department of Molecular Breeding, National Academy of Agricultural Science, Jeonju 560-500, Korea (B.-G.K.);Department of Plant and Microbial Biology, University of California, Berkeley, California 94720 (B.-G.K., S.-C.L., Y.-H.C., S.L.);Department of Life Science, Chung-Ang University, HeukSeok-Dong, Dongjak-Gu, Seoul 156-756, Korea (S.-C.L.); andDepartment of Bio-Environmental Science, Sunchon National University, Suncheon, Jeonnam 540-742, Korea (Y.-H.C.).
Beom-Gi KimDepartment of Plant Molecular Biology, University of Delhi South Campus, New Delhi 110021, India (G.K.P., P.K., A.S., A.P., A.K.Y., I.T., S.K.S.);Molekulargenetik und Zellbiologie der Pflanzen Institut für Biologie und Biotechnologie der Pflanzen, Universität Münster, 48149 Muenster, Germany (L.S., J.K.);Department of Molecular Breeding, National Academy of Agricultural Science, Jeonju 560-500, Korea (B.-G.K.);Department of Plant and Microbial Biology, University of California, Berkeley, California 94720 (B.-G.K., S.-C.L., Y.-H.C., S.L.);Department of Life Science, Chung-Ang University, HeukSeok-Dong, Dongjak-Gu, Seoul 156-756, Korea (S.-C.L.); andDepartment of Bio-Environmental Science, Sunchon National University, Suncheon, Jeonnam 540-742, Korea (Y.-H.C.).
Sung-Chul LeeDepartment of Plant Molecular Biology, University of Delhi South Campus, New Delhi 110021, India (G.K.P., P.K., A.S., A.P., A.K.Y., I.T., S.K.S.);Molekulargenetik und Zellbiologie der Pflanzen Institut für Biologie und Biotechnologie der Pflanzen, Universität Münster, 48149 Muenster, Germany (L.S., J.K.);Department of Molecular Breeding, National Academy of Agricultural Science, Jeonju 560-500, Korea (B.-G.K.);Department of Plant and Microbial Biology, University of California, Berkeley, California 94720 (B.-G.K., S.-C.L., Y.-H.C., S.L.);Department of Life Science, Chung-Ang University, HeukSeok-Dong, Dongjak-Gu, Seoul 156-756, Korea (S.-C.L.); andDepartment of Bio-Environmental Science, Sunchon National University, Suncheon, Jeonnam 540-742, Korea (Y.-H.C.).
Yong-Hwa CheongDepartment of Plant Molecular Biology, University of Delhi South Campus, New Delhi 110021, India (G.K.P., P.K., A.S., A.P., A.K.Y., I.T., S.K.S.);Molekulargenetik und Zellbiologie der Pflanzen Institut für Biologie und Biotechnologie der Pflanzen, Universität Münster, 48149 Muenster, Germany (L.S., J.K.);Department of Molecular Breeding, National Academy of Agricultural Science, Jeonju 560-500, Korea (B.-G.K.);Department of Plant and Microbial Biology, University of California, Berkeley, California 94720 (B.-G.K., S.-C.L., Y.-H.C., S.L.);Department of Life Science, Chung-Ang University, HeukSeok-Dong, Dongjak-Gu, Seoul 156-756, Korea (S.-C.L.); andDepartment of Bio-Environmental Science, Sunchon National University, Suncheon, Jeonnam 540-742, Korea (Y.-H.C.).
Jörg KudlaDepartment of Plant Molecular Biology, University of Delhi South Campus, New Delhi 110021, India (G.K.P., P.K., A.S., A.P., A.K.Y., I.T., S.K.S.);Molekulargenetik und Zellbiologie der Pflanzen Institut für Biologie und Biotechnologie der Pflanzen, Universität Münster, 48149 Muenster, Germany (L.S., J.K.);Department of Molecular Breeding, National Academy of Agricultural Science, Jeonju 560-500, Korea (B.-G.K.);Department of Plant and Microbial Biology, University of California, Berkeley, California 94720 (B.-G.K., S.-C.L., Y.-H.C., S.L.);Department of Life Science, Chung-Ang University, HeukSeok-Dong, Dongjak-Gu, Seoul 156-756, Korea (S.-C.L.); andDepartment of Bio-Environmental Science, Sunchon National University, Suncheon, Jeonnam 540-742, Korea (Y.-H.C.).
Sheng LuanDepartment of Plant Molecular Biology, University of Delhi South Campus, New Delhi 110021, India (G.K.P., P.K., A.S., A.P., A.K.Y., I.T., S.K.S.);Molekulargenetik und Zellbiologie der Pflanzen Institut für Biologie und Biotechnologie der Pflanzen, Universität Münster, 48149 Muenster, Germany (L.S., J.K.);Department of Molecular Breeding, National Academy of Agricultural Science, Jeonju 560-500, Korea (B.-G.K.);Department of Plant and Microbial Biology, University of California, Berkeley, California 94720 (B.-G.K., S.-C.L., Y.-H.C., S.L.);Department of Life Science, Chung-Ang University, HeukSeok-Dong, Dongjak-Gu, Seoul 156-756, Korea (S.-C.L.); andDepartment of Bio-Environmental Science, Sunchon National University, Suncheon, Jeonnam 540-742, Korea (Y.-H.C.) gkpandey@south.du.ac.in sluan@berkeley.edu.
University of Delhi · INChung-Ang University · KRNational Academy of Agricultural Science · KRSunchon National University · KRUniversity of California, Berkeley · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of calcium-mediated signaling has been extensively studied in plant responses to abiotic stress signals. Calcineurin B-like proteins (CBLs) and CBL-interacting protein kinases (CIPKs) constitute a complex signaling network acting in diverse plant stress responses. Osmotic stress imposed by soil salinity and drought is a major abiotic stress that impedes plant growth and development and involves calcium-signaling processes. In this study, we report the functional analysis of CIPK21, an Arabidopsis (Arabidopsis thaliana) CBL-interacting protein kinase, ubiquitously expressed in plant tissues and up-regulated under multiple abiotic stress conditions. The growth of a loss-of-function mutant of CIPK21, cipk21, was hypersensitive to high salt and osmotic stress conditions. The calcium sensors CBL2 and CBL3 were found to physically interact with CIPK21 and target this kinase to the tonoplast. Moreover, preferential localization of CIPK21 to the tonoplast was detected under salt stress condition when coexpressed with CBL2 or CBL3. These findings suggest that CIPK21 mediates responses to salt stress condition in Arabidopsis, at least in part, by regulating ion and water homeostasis across the vacuolar membranes.
Indexed as
ArabidopsisArabidopsis ProteinsCalcium-Binding ProteinsDNA, BacterialGene Expression Regulation, PlantGenetic Complementation TestMannitolModels, BiologicalMutagenesis, InsertionalMutationOsmosisPhenotypeProtein Serine-Threonine KinasesSodium ChlorideStress, PhysiologicalUp-RegulationArabidopsis ProteinsAt5g55990 protein, ArabidopsisCalcium-Binding ProteinsCBL3 protein, ArabidopsisCIPK21 protein, ArabidopsisDNA, BacterialMannitolProtein Serine-Threonine KinasesSodium ChlorideT-DNA
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