ArticleBiosensors2015
Characterization of Lactate Sensors Based on Lactate Oxidase and Palladium Benzoporphyrin Immobilized in Hydrogels.
Article in Biosensors, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- 3D-Printed Flexible Conductive Hydrogel as a Wearable Platform for Dual Functions of Strain and Colorimetric Lactate Sensors.ACS applied materials & interfaces · 2025Article
- Dual-mode detection of lactic acid using B, N-doped carbon dots with peroxidase-mimicking activity for diabetes monitoring.Mikrochimica acta · 2025Article
- Insertable Biomaterial-Based Multianalyte Barcode Sensor toward Continuous Monitoring of Glucose and Oxygen.ACS sensors · 2024Article
- Long-Term Evaluation of Inserted Nanocomposite Hydrogel-Based Phosphorescent Oxygen Biosensors: Evolution of Local Tissue Oxygen Levels and Foreign Body Response.ACS applied bio materials · 2024Article
- Tissue Reaction to Low-Density Polyacrylamide Gel as a Carrier for Microimplants in the Adipose Fin of Rainbow Trout.Gels (Basel, Switzerland) · 2023Article
- Glucose biosensors based on Michael addition crosslinked poly(ethylene glycol) hydrogels with chemo-optical sensing microdomains.Journal of materials chemistry. B · 2023Article
- NIR Luminescent Oxygen-Sensing Nanoparticles for Continuous Glucose and Lactate Monitoring.Biosensors · 2023Article
- Adipose Fin as a Natural "Optical Window" for Implantation of Fluorescent Sensors into Salmonid Fish.Animals : an open access journal from MDPI · 2022Article
- Geometry design for a fully insertable glucose biosensor with multimodal optical readout.Journal of biomedical optics · 2022Article
- Monte Carlo method for assessment of a multimodal insertable biosensor.Journal of biomedical optics · 2022Article
- Inorganic-Organic Interpenetrating Network Hydrogels as Tissue-Integrating Luminescent Implants: Physicochemical Characterization and Preclinical Evaluation.Macromolecular bioscience · 2022Article
- Transcutaneous Flexible Sensor forACS sensors · 2022Article
- Employment of 1-Methoxy-5-Ethyl Phenazinium Ethyl Sulfate as a Stable Electron Mediator in Flavin Oxidoreductases-Based Sensors.Sensors (Basel, Switzerland) · 2020Article
- Near-Infrared Optical Nanosensors for Continuous Detection of Glucose.Journal of diabetes science and technology · 2020Article
- An Optical Urate Biosensor Based on Urate Oxidase and Long-Lifetime Metalloporphyrins.Sensors (Basel, Switzerland) · 2020Article
- Immobilized Enzymes in Biosensor Applications.Materials (Basel, Switzerland) · 2019Review
- Sensors for Fetal Hypoxia and Metabolic Acidosis: A Review.Sensors (Basel, Switzerland) · 2018Review
- Composite Hydrogels with Engineered Microdomains for Optical Glucose Sensing at Low Oxygen Conditions.Biosensors · 2017Article
- Enzyme Biosensors for Biomedical Applications: Strategies for Safeguarding Analytical Performances in Biological Fluids.Sensors (Basel, Switzerland) · 2016Review
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
An optical biosensor for lactate detection is described. By encapsulating enzyme-phosphor sensing molecules within permeable hydrogel materials, lactate-sensitive emission lifetimes were achieved. The relative amount of monomer was varied to compare three homo- and co-polymer materials: poly(2-hydroxyethyl methacrylate) (pHEMA) and two copolymers of pHEMA and poly(acrylamide) (pAam). Diffusion analysis demonstrated the ability to control lactate transport by varying the hydrogel composition, while having a minimal effect on oxygen diffusion. Sensors displayed the desired dose-variable response to lactate challenges, highlighting the tunable, diffusion-controlled nature of the sensing platform. Short-term repeated exposure tests revealed enhanced stability for sensors comprising hydrogels with acrylamide additives; after an initial "break-in" period, signal retention was 100% for 15 repeated cycles. Finally, because this study describes the modification of a previously developed glucose sensor for lactate analysis, it demonstrates the potential for mix-and-match enzyme-phosphor-hydrogel sensing for use in future multi-analyte sensors.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.