ReviewOrphanet journal of rare diseases2015
Idiopathic (primary) achalasia: a review.
Review in Orphanet journal of rare diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 72 citations in OpenAlex.
- Surgical and endoscopic interventions in the management of idiopathic achalasia.The Cochrane database of systematic reviews · 2025Article
- Urdu adaptation and validation of a disease-specific quality-of-life questionnaire in a Pakistani population of Achalasia.PloS one · 2025Article
- Infantile achalasia cardia: A rare case report of a 3-month-old female with recurrent pneumonia successfully treated with surgical intervention.International journal of surgery case reports · 2025Article
- Neonatal Achalasia Cardia: A Case Report.Cureus · 2024Article
- Achalasia Cardia: A Case Series.JNMA; journal of the Nepal Medical Association · 2024Article
- Assessment of the Physical Invasiveness of Peroral Endoscopic Myotomy during the Perioperative Period Based on Changes in Energy Metabolism.Metabolites · 2023Article
- Use of a videofluoroscopic feeding evaluation to guide management of dogs with congenital idiopathic megaoesophagus.Veterinary medicine and science · 2022Article
- Advances in The Diagnosis and Treatment of Achalasia of The Cardia: a Review.Journal of translational internal medicine · 2021Article
- Soluble Guanylate Cyclase Stimulators and Activators.Handbook of experimental pharmacology · 2021Article
- Comparison of Oral and Esophageal Microbiota in Patients with Achalasia Before and After Peroral Endoscopic Myotomy.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2021Observational
- Retrospective study on symptoms and treatment modalities used and short-term follow up of achalasia cardia in Indian setting.JGH open : an open access journal of gastroenterology and hepatology · 2020Article
- Eating disorder or oesophageal achalasia during adolescence: diagnostic difficulties.Eating and weight disorders : EWD · 2020Article
- Achalasia cardia: A diagnosis often delayed!Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2019Article
- Recurrent episodes of esophageal candidiasis without dysphagia post-Guillain-Barré syndrome: an unusual presentation of achalasia.BMJ case reports · 2017Article
- An Overview of Achalasia and Its Subtypes.Gastroenterology & hepatology · 2017Article
- Anaesthetic Management of a Case of Down's Syndrome with Achalasia Cardia.Journal of clinical and diagnostic research : JCDR · 2016Article
- New insights into the pathophysiology of achalasia and implications for future treatment.World journal of gastroenterology · 2016Review
- Prosthetic rehabilitation in patient with achalasia cardia - A rare case report.Journal of International Society of Preventive & Community DentistryArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Idiopathic achalasia is a primary esophageal motor disorder characterized by loss of esophageal peristalsis and insufficient lower esophageal sphincter relaxation in response to deglutition. Patients with achalasia commonly complain of dysphagia to solids and liquids, bland regurgitation often unresponsive to an adequate trial of proton pump inhibitor, and chest pain. Weight loss is present in many, but not all patients. Although the precise etiology is unknown, it is often thought to be either autoimmune, viral immune, or neurodegenerative. The diagnosis is based on history of the disease, barium esophagogram, and esophageal motility testing. Endoscopic assessment of the gastroesophageal junction and gastric cardia is necessary to rule out malignancy. Newer diagnostic modalities such as high resolution manometry help in predicting treatment response in achalasia based on esophageal pressure topography patterns identifying three phenotypes of achalasia (I-III) and outcome studies suggest better treatment response with types I and II compared to type III. Although achalasia cannot be permanently cured, excellent outcomes are achieved in over 90 % of patients. Current medical and surgical therapeutic options (pneumatic dilation, endoscopic and surgical myotomy, and pharmacologic agents) aim at reducing the LES pressure and facilitating esophageal emptying by gravity and hydrostatic pressure of retained food and liquids. Either graded pneumatic dilatation or laparoscopic surgical myotomy with a partial fundoplication are recommended as initial therapy guided by patient age, gender, preference, and local institutional expertise. The prognosis in achalasia patients is excellent. Most patients who are appropriately treated have a normal life expectancy but the disease does recur and the patient may need intermittent treatment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.