ArticleScientific reports2015
Ecdysone promotes growth of imaginal discs through the regulation of Thor in D. melanogaster.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 104 citations in OpenAlex.
- NFYB Integrates Hormonal Signals into Tissue Allometry by Promoting Protein Biosynthesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Control of metabolism by hypoxia and starvation and the consequences for the pattern of ecdysone secretion in Manduca sexta.The Journal of experimental biology · 2026Article
- Imaginal discs produce neuropeptide-like precursor 1 to alleviate ER stress in response to warm temperatures.Communications biology · 2025Article
- SRP/dGATAb modulates the ecdysone response bidirectionally via locus-specific regulatory landscape.Epigenetics & chromatin · 2025Article
- Remote control of AMPK via extracellular adenosine controls tissue growth.Nature cell biology · 2025Article
- Developmental analysis of Spalt function in the Drosophila prothoracic gland.Development (Cambridge, England) · 2024Article
- Local Ecdysone synthesis in a wounded epithelium sustains developmental delay and promotes regeneration in Drosophila.Development (Cambridge, England) · 2024Article
- Local ecdysone synthesis in a wounded epithelium sustains developmental delay and promotes regeneration inbioRxiv : the preprint server for biology · 2024Article
- The Drosophila ecdysone receptor promotes or suppresses proliferation according to ligand level.Developmental cell · 2023Article
- Colorimetric Synchronization of Drosophila Larvae.Current protocols · 2023Article
- Asynchronous transcription and translation of neurotransmitter-related genes characterize the initial stages of neuronal maturation in Drosophila.PLoS biology · 2023Article
- Nuclear receptors EcR-A/RXR and HR3 control early embryogenesis in the short-germ hemimetabolous insectiScience · 2023Article
- Maintaining robust size across environmental conditions through plastic brain growth dynamics.Open biology · 2022Article
- The wing imaginal disc.Genetics · 2022Article
- The steroid hormone ecdysone regulates growth rate in response to oxygen availability.Scientific reports · 2022Article
- Article
- Endocrine Regulation of Lifespan in Insect Diapause.Frontiers in physiology · 2022Review
- Ecdysone regulates Drosophila wing disc size via a TORC1 dependent mechanism.Nature communications · 2021Article
- Transcriptome dynamics during metamorphosis of imaginal discs into wings and thoracic dorsum in Apis mellifera castes.BMC genomics · 2021Article
- Balancing energy expenditure and storage with growth and biosynthesis during Drosophila development.Developmental biology · 2021Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Animals have a determined species-specific body size that results from the combined action of hormones and signaling pathways regulating growth rate and duration. In Drosophila, the steroid hormone ecdysone controls developmental transitions, thereby regulating the duration of the growth period. Here we show that ecdysone promotes the growth of imaginal discs in mid-third instar larvae, since imaginal discs from larvae with reduced or no ecdysone synthesis are smaller than wild type due to smaller and fewer cells. We show that insulin-like peptides are produced and secreted normally in larvae with reduced ecdysone synthesis, and upstream components of insulin/insulin-like signaling are activated in their discs. Instead, ecdysone appears to regulate the growth of imaginal discs via Thor/4E-BP, a negative growth regulator downstream of the insulin/insulin-like growth factor/Tor pathways. Discs from larvae with reduced ecdysone synthesis have elevated levels of Thor, while mutations in Thor partially rescue their growth. The regulation of organ growth by ecdysone is evolutionarily conserved in hemimetabolous insects, as shown by our results obtained using Blattella germanica. In summary, our data provide new insights into the relationship between components of the insulin/insulin-like/Tor and ecdysone pathways in the control of organ growth.
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