ArticleMolecular ecology2015
Evolutionary history inferred from the de novo assembly of a nonmodel organism, the blue-eyed black lemur.
Article in Molecular ecology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Hyper-specialized primates possess a reduced suite of xenobiotic-metabolizing cytochrome P450 genes.Molecular phylogenetics and evolution · 2026Article
- Genetic characterization of Macaca arctoides: A highlight of key genes and pathways.Primates; journal of primatology · 2023Article
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- The contribution of historical processes to contemporary extinction risk in placental mammals.Science (New York, N.Y.) · 2023Article
- Functional genomics analysis reveals the evolutionary adaptation and demographic history of pygmy lorises.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- A New World Monkey Resembles Human in Bitter Taste Receptor Evolution and Function via a Single Parallel Amino Acid Substitution.Molecular biology and evolution · 2021Article
- Impact of model assumptions on demographic inferences: the case study of two sympatric mouse lemurs in northwestern Madagascar.BMC ecology and evolution · 2021Article
- Comparative genomic analysis of sifakas (Science advances · 2021Article
- Comparative Genomic Analysis of the Pheromone Receptor Class 1 Family (V1R) Reveals Extreme Complexity in Mouse Lemurs (Genus, Microcebus) and a Chromosomal Hotspot across Mammals.Genome biology and evolution · 2020Article
- Article
- A natural point mutation in the bitter taste receptor TAS2R16 causes inverse agonism of arbutin in lemur gustation.Proceedings. Biological sciences · 2019Article
- IDP-denovo: de novo transcriptome assembly and isoform annotation by hybrid sequencing.Bioinformatics (Oxford, England) · 2018Article
- Genome sequence and population declines in the critically endangered greater bamboo lemur (Prolemur simus) and implications for conservation.BMC genomics · 2018Article
- Genome sequencing of Metrosideros polymorpha (Myrtaceae), a dominant species in various habitats in the Hawaiian Islands with remarkable phenotypic variations.Journal of plant research · 2016Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
Lemurs, the living primates most distantly related to humans, demonstrate incredible diversity in behaviour, life history patterns and adaptive traits. Although many lemur species are endangered within their native Madagascar, there is no high-quality genome assembly from this taxon, limiting population and conservation genetic studies. One critically endangered lemur is the blue-eyed black lemur Eulemur flavifrons. This species is fixed for blue irises, a convergent trait that evolved at least four times in primates and was subject to positive selection in humans, where 5' regulatory variation of OCA2 explains most of the brown/blue eye colour differences. We built a de novo genome assembly for E. flavifrons, providing the most complete lemur genome to date, and a high confidence consensus sequence for close sister species E. macaco, the (brown-eyed) black lemur. From diversity and divergence patterns across the genomes, we estimated a recent split time of the two species (160 Kya) and temporal fluctuations in effective population sizes that accord with known environmental changes. By looking for regions of unusually low diversity, we identified potential signals of directional selection in E. flavifrons at MITF, a melanocyte development gene that regulates OCA2 and has previously been associated with variation in human iris colour, as well as at several other genes involved in melanin biosynthesis in mammals. Our study thus illustrates how whole-genome sequencing of a few individuals can illuminate the demographic and selection history of nonmodel species.
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