Evidence map›Paper›PMID 26198033›Full record

ArticleScience (New York, N.Y.)2015

POPULATION GENETICS. Genomic evidence for the Pleistocene and recent population history of Native Americans.

Maanasa Raghavan, Matthias Steinrücken, Kelley Harris, Stephan Schiffels, Simon Rasmussen, Michael DeGiorgio, Anders Albrechtsen, Cristina Valdiosera, María C Ávila-Arcos, Anna-Sapfo Malaspinas and 91 more

Abstract readHistorical Article
PubMed Full text at PMC Publisher
In one paragraph

Article in Science (New York, N.Y.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 219 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
219citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

219 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
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  9. On the Edge of Empire: Paleogenomic Insights into Roman Dacia.bioRxiv : the preprint server for biology · 2026
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  14. Global patterns of natural selection inferred using ancient DNA.bioRxiv : the preprint server for biology · 2026
    Article
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  17. Review
  18. Review
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159 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

101 authors.

Maanasa Raghavan *Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.
Matthias Steinrücken *Computer Science Division, University of California, Berkeley, CA 94720, USA.
Kelley Harris *Department of Mathematics, University of California, Berkeley, CA 94720, USA.
Stephan Schiffels *Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK.
Simon Rasmussen *Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Kemitorvet, Building 208, 2800 Kongens Lyngby, Denmark.
Michael DeGiorgio *Departments of Biology and Statistics, Pennsylvania State University, 502 Wartik Laboratory, University Park, PA 16802, USA.
Anders Albrechtsen *The Bioinformatics Centre, Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark.
Cristina Valdiosera *Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.
María C Ávila-Arcos *Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.
Anna-Sapfo Malaspinas *Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.
Anders ErikssonDepartment of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK.
Ida MoltkeThe Bioinformatics Centre, Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark.
Mait MetspaluEstonian Biocentre, Evolutionary Biology Group, Tartu 51010, Estonia.
Julian R HomburgerDepartment of Genetics, School of Medicine, Stanford University, 300 Pasteur Dr. Lane Bldg Room L331, Stanford, California 94305, USA.
Jeff WallInstitute for Human Genetics, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA.
Omar E CornejoSchool of Biological Sciences, Washington State University, PO Box 644236, Heald 429, Pullman, Washington 99164, USA.
J Víctor Moreno-MayarCentre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.
Thorfinn S KorneliussenCentre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.
Tracey PierreCentre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.
Morten RasmussenCentre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.
Paula F CamposCentre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.
Peter de Barros DamgaardCentre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.
Morten E AllentoftCentre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.
John LindoDepartment of Anthropology, University of Illinois at Urbana-Champaign, 607 S. Mathews Ave, Urbana, IL 61801, USA.
Ene MetspaluEstonian Biocentre, Evolutionary Biology Group, Tartu 51010, Estonia.
Ricardo Rodríguez-VarelaCentro Mixto, Universidad Complutense de Madrid-Instituto de Salud Carlos III de Evolución y Comportamiento Humano, Madrid, Spain.
Josefina MansillaInstituto Nacional de Antropología e Historia, Moneda 13, Centro, Cuauhtémoc, 06060 Mexico Mexico City, Mexico.
Celeste HenricksonUniversity of Utah, Department of Anthropology, 270 S 1400 E, Salt Lake City, Utah 84112, USA.
Andaine Seguin-OrlandoCentre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.
Helena MalmströmDepartment of Evolutionary Biology and Science for Life Laboratory, Uppsala University, Norbyvägen 18D, SE-752 36 Uppsala, Sweden.
Thomas StaffordCentre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.
Suyash S ShringarpureDepartment of Genetics, School of Medicine, Stanford University, 300 Pasteur Dr. Lane Bldg Room L331, Stanford, California 94305, USA.
Andrés Moreno-EstradaDepartment of Genetics, School of Medicine, Stanford University, 300 Pasteur Dr. Lane Bldg Room L331, Stanford, California 94305, USA.
Monika KarminEstonian Biocentre, Evolutionary Biology Group, Tartu 51010, Estonia.
Kristiina TambetsEstonian Biocentre, Evolutionary Biology Group, Tartu 51010, Estonia.
Anders BergströmWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK.
Yali XueWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK.
Vera WarmuthUCL Genetics Institute, Gower Street, London WC1E 6BT, UK.
Andrew D FriendDepartment of Geography, University of Cambridge, Downing Place, Cambridge CB2 3EN, UK.
Joy SingarayerCentre for Past Climate Change and Department of Meteorology, University of Reading, Earley Gate, PO Box 243, Reading, UK.
Paul ValdesSchool of Geographical Sciences, University Road, Clifton, Bristol BS8 1SS, UK.
Francois BallouxUCL Genetics Institute, Gower Street, London WC1E 6BT, UK.
Ilán LeboreiroInstituto Nacional de Antropología e Historia, Moneda 13, Centro, Cuauhtémoc, 06060 Mexico Mexico City, Mexico.
Jose Luis VeraEscuela Nacional de AntropologÍa e Historia, Periférico Sur y Zapote s/n. Colonia Isidro Fabela, Tlalpan, Isidro Fabela, 14030 Mexico City, Mexico.
Hector Rangel-VillalobosInstituto de Investigación en Genética Molecular, Universidad de Guadalajara, Ocotlán, Mexico.
Davide PettenerDipartimento di Scienze Biologiche, Geologiche e Ambientali (BiGeA), Università di Bologna, Via Selmi 3, 40126 Bologna, Italy.
Donata LuiselliDipartimento di Scienze Biologiche, Geologiche e Ambientali (BiGeA), Università di Bologna, Via Selmi 3, 40126 Bologna, Italy.
Loren G DavisDepartment of Anthropology, Oregon State University, 238 Waldo Hall, Corvallis, OR, 97331 USA.
Evelyne HeyerMuseum National d'Histoire Naturelle, CNRS, Université Paris 7 Diderot, Sorbonne Paris Cité, Sorbonne Universités, Unité Eco-Anthropologie et Ethnobiologie (UMR7206), Paris, France.
Christoph P E ZollikoferAnthropological Institute and Museum, University of Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland.
Marcia S Ponce de LeónAnthropological Institute and Museum, University of Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland.
Colin I SmithDepartment of Archaeology and History, La Trobe University, Melbourne, Victoria 3086, Australia.
Vaughan GrimesDepartment of Archaeology, Memorial University, Queen's College, 210 Prince Philip Drive, St. John's, Newfoundland, A1C 5S7, Canada.
Kelly-Anne PikeDepartment of Archaeology, Memorial University, Queen's College, 210 Prince Philip Drive, St. John's, Newfoundland, A1C 5S7, Canada.
Michael DealDepartment of Archaeology, Memorial University, Queen's College, 210 Prince Philip Drive, St. John's, Newfoundland, A1C 5S7, Canada.
Benjamin T FullerDepartment of Earth System Science, University of California, Irvine, Keck CCAMS Group, B321 Croul Hall, Irvine, California, 92697, USA.
Bernardo ArriazaInstituto de Alta Investigación, Universidad de Tarapacá, 18 de Septiembre 2222, Carsilla 6-D Arica, Chile.
Vivien StandenDepartamento de Antropologia, Universidad de Tarapacá, 18 de Septiembre 2222. Casilla 6-D Arica, Chile.
Maria F LuzFundação Museu do Homem Americano, Centro Cultural Sérgio Motta, Campestre, 64770-000 Sao Raimundo Nonato, Brazil.
Francois RicautLaboratoire d'Anthropologie Moléculaire et Imagérie de Synthèse UMR-5288, CNRS, Université de Toulouse, 31073 Toulouse, France.
Niede GuidonFundação Museu do Homem Americano, Centro Cultural Sérgio Motta, Campestre, 64770-000 Sao Raimundo Nonato, Brazil.
Ludmila OsipovaInstitute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Prospekt Lavrentyeva 10, 630090 Novosibirsk, Russia.
Mikhail I VoevodaInstitute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Prospekt Lavrentyeva 10, 630090 Novosibirsk, Russia.
Olga L PosukhInstitute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Prospekt Lavrentyeva 10, 630090 Novosibirsk, Russia.
Oleg BalanovskyVavilov Institute of General Genetics, Gubkina 3, 119333 Moscow, Russia.
Maria LavryashinaKemerovo State University, Krasnaya 3, 650000 Kemerovo, Russia.
Yuri BogunovVavilov Institute of General Genetics, Gubkina 3, 119333 Moscow, Russia.
Elza KhusnutdinovaInstitute of Biochemistry and Genetics, Ufa Scientific Center of RAS, Prospekt Oktyabrya 71, 450054 Ufa, Russia.
Marina GubinaFundação Museu do Homem Americano, Centro Cultural Sérgio Motta, Campestre, 64770-000 Sao Raimundo Nonato, Brazil.
Elena BalanovskaResearch Centre for Medical Genetics, Moskvorechie 1, 115478 Moscow, Russia.
Sardana FedorovaDepartment of Molecular Genetics, Yakut Scientific Centre of Complex Medical Problems, Sergelyahskoe Shosse 4, 677010 Yakutsk, Russia.
Sergey LitvinovEstonian Biocentre, Evolutionary Biology Group, Tartu 51010, Estonia.
Boris MalyarchukInstitute of Biological Problems of the North, Russian Academy of Sciences, Portovaya Street 18, Magadan 685000, Russia.
Miroslava DerenkoInstitute of Biological Problems of the North, Russian Academy of Sciences, Portovaya Street 18, Magadan 685000, Russia.
M J MosherDepartment of Anthropology, Western Washington University, Bellingham Washington 98225, USA.
David ArcherDepartment of Anthropology, Northwest Community College, 353 Fifth Street, Prince Rupert, British Columbia V8J 3L6, Canada.
Jerome CybulskiCanadian Museum of History, 100 Rue Laurier, Gatineau, Quebec K1A 0M8, Canada.
Barbara PetzeltMetlakatla Treaty Office, PO Box 224, Prince Rupert, BC, Canada V8J 3P6.
Joycelynn MitchellMetlakatla Treaty Office, PO Box 224, Prince Rupert, BC, Canada V8J 3P6.
Rosita WorlSealaska Heritage Institute, 105 S. Seward Street, Juneau, Alaska 99801, USA.
Paul J NormanDepartment of Structural Biology, Stanford University School of Medicine, D100 Fairchild Science Building, Stanford, California 94305-5126, USA.
Peter ParhamDepartment of Structural Biology, Stanford University School of Medicine, D100 Fairchild Science Building, Stanford, California 94305-5126, USA.
Brian M KempSchool of Biological Sciences, Washington State University, PO Box 644236, Heald 429, Pullman, Washington 99164, USA.
Toomas KivisildEstonian Biocentre, Evolutionary Biology Group, Tartu 51010, Estonia.
Chris Tyler-SmithWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK.
Manjinder S SandhuWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK.
Michael CrawfordLaboratory of Biological Anthropology, University of Kansas, 1415 Jayhawk Blvd., 622 Fraser Hall, Lawrence, Kansas 66045, USA.
Richard VillemsEstonian Biocentre, Evolutionary Biology Group, Tartu 51010, Estonia.
David Glenn SmithMolecular Anthropology Laboratory, 209 Young Hall, Department of Anthropology, University of California, One Shields Avenue, Davis, California 95616, USA.
Michael R WatersCenter for the Study of the First Americans, Texas A&M University, College Station, Texas 77843-4352, USA.
Ted GoebelCenter for the Study of the First Americans, Texas A&M University, College Station, Texas 77843-4352, USA.
John R JohnsonSanta Barbara Museum of Natural History, 2559 Puesta del Sol, Santa Barbara, CA 93105, USA.
Ripan S MalhiDepartment of Anthropology, University of Illinois at Urbana-Champaign, 607 S. Mathews Ave, Urbana, IL 61801, USA.
Mattias JakobssonDepartment of Evolutionary Biology and Science for Life Laboratory, Uppsala University, Norbyvägen 18D, SE-752 36 Uppsala, Sweden.
David J MeltzerCentre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.
Andrea ManicaDepartment of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK.
Richard DurbinWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK.
Carlos D BustamanteDepartment of Genetics, School of Medicine, Stanford University, 300 Pasteur Dr. Lane Bldg Room L331, Stanford, California 94305, USA.
Yun S SongComputer Science Division, University of California, Berkeley, CA 94720, USA.
Rasmus NielsenDepartment of Integrative Biology, University of California, 3060 Valley Life Sciences Bldg #3140, Berkeley, CA 94720, USA.
Eske WillerslevCentre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.

Funding

Insights Into Immune-Related Diseases Born from Population GenomicsU01AI090905 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Paul John Norman · 2010 to 2026
$10.9M
STRUCTURAL BIOLOGY OF HLA-A,B ANTIGENSR01AI017892 · NIAID · STANFORD UNIVERSITY · PI PARHAM, PETER R · 1985 to 2019
$6.1M
Population Genetic Inferences From Dense Genotype DataR01HG003229 · NHGRI · CORNELL UNIVERSITY ITHACA · PI BUSTAMANTE, CARLOS DANIEL, CLARK, ANDREW G · 2004 to 2013
$4.8M
Mathematical Models and Statistical Methods for Large-Scale Population GenomicsR01GM094402 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI SONG, YUN S · 2010 to 2018
$2.2M
Genomic Origins and Admixture in Latinos (GOAL)R01GM090087 · NIGMS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BUSTAMANTE, CARLOS DANIEL, MARTIN, EDEN R. · 2011 to 2014
$1.6M
Biotechnology and Biological Sciences Research Council BB/H005854/1Biotechnology and Biological Sciences Research Council BB/H008802/1European Research Council 261213European Research Council 295733NHGRI NIH HHS 2R01HG003229-09NHGRI NIH HHS R01 HG003229NIAID NIH HHS R01 AI017892NIAID NIH HHS R01-AI17892NIAID NIH HHS U01 AI090905NIGMS NIH HHS R01 GM090087NIGMS NIH HHS R01 GM094402NIGMS NIH HHS R01-GM094402Wellcome TrustWellcome Trust 098051
6 · The paper itself

Abstract

How and when the Americas were populated remains contentious. Using ancient and modern genome-wide data, we found that the ancestors of all present-day Native Americans, including Athabascans and Amerindians, entered the Americas as a single migration wave from Siberia no earlier than 23 thousand years ago (ka) and after no more than an 8000-year isolation period in Beringia. After their arrival to the Americas, ancestral Native Americans diversified into two basal genetic branches around 13 ka, one that is now dispersed across North and South America and the other restricted to North America. Subsequent gene flow resulted in some Native Americans sharing ancestry with present-day East Asians (including Siberians) and, more distantly, Australo-Melanesians. Putative "Paleoamerican" relict populations, including the historical Mexican Pericúes and South American Fuego-Patagonians, are not directly related to modern Australo-Melanesians as suggested by the Paleoamerican Model.

Indexed as

AmericasGene FlowGenomicsHistory, AncientHuman MigrationHumansIndians, North AmericanModels, GeneticSiberia

Identifiers

PMID26198033
PMCPMC4733658

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