Evidence map›Paper›PMID 26197973›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2015

Mapping Local Cytosolic Enzymatic Activity in Human Esophageal Mucosa with Porous Silicon Nanoneedles.

Ciro Chiappini, Paola Campagnolo, Carina S Almeida, Nima Abbassi-Ghadi, Lesley W Chow, George B Hanna, Molly M Stevens

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Article
  2. Smart micro/nanoneedles for gene delivery.Iranian journal of basic medical sciences · 2026
    Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Synthetic living materials in cancer biology.Nature reviews bioengineering · 2023
    Article
  11. Review
  12. Recent advances in single-cell subcellular sampling.Chemical communications (Cambridge, England) · 2023
    Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Nanoneedle-Based Materials for Intracellular Studies.Advances in experimental medicine and biology · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ciro ChiappiniDepartment of Materials, Department of Bioengineering, Institute of Biomedical Engineering, Imperial College London, SW7 2AZ, London, UK.
Paola CampagnoloDepartment of Materials, Department of Bioengineering, Institute of Biomedical Engineering, Imperial College London, SW7 2AZ, London, UK.
Carina S AlmeidaDepartment of Materials, Department of Bioengineering, Institute of Biomedical Engineering, Imperial College London, SW7 2AZ, London, UK.
Nima Abbassi-GhadiDepartment of Surgery and Cancer, Imperial College London, W2 1PG, London, UK.
Lesley W ChowDepartment of Materials, Department of Bioengineering, Institute of Biomedical Engineering, Imperial College London, SW7 2AZ, London, UK.
George B HannaDepartment of Surgery and Cancer, Imperial College London, W2 1PG, London, UK.
Molly M StevensDepartment of Materials, Department of Bioengineering, Institute of Biomedical Engineering, Imperial College London, SW7 2AZ, London, UK.

Funding

European Research Council 616417Wellcome Trust 088844Wellcome Trust 098411Wellcome Trust 098411/Z/12/Z
6 · The paper itself

Abstract

Porous silicon nanoneedles can map Cathepsin B activity across normal and tumor human esophageal mucosa. Assembling a peptide-based Cathepsin B cleavable sensor over a large array of nano-needles allows the discrimination of cancer cells from healthy ones in mixed culture. The same sensor applied to tissue can map Cathepsin B activity with high resolution across the tumor margin area of esophageal adenocarcinoma.

Indexed as

Biosensing TechniquesCathepsin BCell Line, TumorCytosolEsophagusHumansMucous MembraneNanotechnologyPorositySiliconCathepsin BCTSB protein, humanSilicondiagnosticsintracellular sensingnanomedicinenanoneedlesporous silicon

Identifiers

PMID26197973
PMCPMC4858817

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.