ArticlePhysiological reports2015
Intramuscular anabolic signaling and endocrine response following high volume and high intensity resistance exercise protocols in trained men.
Article in Physiological reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 53 citations in OpenAlex.
- Acute Alpha-Glycerylphosphorylcholine Supplementation Enhances Cognitive Performance in Healthy Men.Nutrients · 2024Trial
- Anabolic myokine responses and muscular performance following 8 weeks of autoregulated compared to linear resistance exercise in recreationally active males.Hormones (Athens, Greece) · 2024Trial
- Acute Effects of a High Volume vs. High Intensity Bench Press Protocol on Electromechanical Delay and Muscle Morphology in Recreationally Trained Women.International journal of environmental research and public health · 2021Trial
- Effects of 6 Weeks of Traditional Resistance Training or High Intensity Interval Resistance Training on Body Composition, Aerobic Power and Strength in Healthy Young Subjects: A Randomized Parallel Trial.International journal of environmental research and public health · 2020Trial
- Low-load blood flow restriction elicits greater concentric strength than non-blood flow restriction resistance training but similar isometric strength and muscle size.European journal of applied physiology · 2020Trial
- Comparison of the recovery response from high-intensity and high-volume resistance exercise in trained men.European journal of applied physiology · 2017Trial
- Intramuscular MAPK signaling following high volume and high intensity resistance exercise protocols in trained men.European journal of applied physiology · 2016Trial
- Molecular Protein Interactions and Predictive Pathways as Biomarkers for Enhancing Volleyball Performance: A Narrative Review.Biomarker insights · 2026Review
- Muscle Hypertrophy, Strength, and Salivary Hormone Changes Following 9 Weeks of High- or Low-Load Resistance Training.Journal of functional morphology and kinesiology · 2025Article
- Muscle activation and coordinated movements of infant rolling.Journal of biomechanics · 2024Article
- Phase angle, muscle tissue, and resistance training.Reviews in endocrine & metabolic disorders · 2023Review
- Alcohol, Resistance Exercise, and mTOR Pathway Signaling: An Evidence-Based Narrative Review.Biomolecules · 2022Review
- Interference Phenomenon with Concurrent Strength and High-Intensity Interval Training-Based Aerobic Training: An Updated Model.Sports medicine (Auckland, N.Z.) · 2021Article
- Article
- Adaption of Maximal Glycolysis Rate after Resistance Exercise with Different Volume Load.Sports medicine international open · 2020Article
- The Effect of ProHydrolaseSports (Basel, Switzerland) · 2020Article
- Growth Hormone(s), Testosterone, Insulin-Like Growth Factors, and Cortisol: Roles and Integration for Cellular Development and Growth With Exercise.Frontiers in endocrinology · 2020Review
- Signaling responses to high and moderate load strength exercise in trained muscle.Physiological reports · 2019Article
- Heavy vs Light Load Single-Joint Exercise Performance with Different Rest Intervals.Journal of human kinetics · 2017Article
- Role of metabolic stress for enhancing muscle adaptations: Practical applications.World journal of methodology · 2017Review
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Resistance exercise paradigms are often divided into high volume (HV) or high intensity (HI) protocols, however, it is unknown whether these protocols differentially stimulate mTORC1 signaling. The purpose of this study was to examine mTORC1 signaling in conjunction with circulating hormone concentrations following a typical HV and HI lower-body resistance exercise protocol. Ten resistance-trained men (24.7 ± 3.4 years; 90.1 ± 11.3 kg; 176.0 ± 4.9 cm) performed each resistance exercise protocol in a random, counterbalanced order. Blood samples were obtained at baseline (BL), immediately (IP), 30 min (30P), 1 h (1H), 2 h (2H), and 5 h (5H) postexercise. Fine needle muscle biopsies were completed at BL, 1H, and 5H. Electromyography of the vastus lateralis was also recorded during each protocol. HV and HI produced a similar magnitude of muscle activation across sets. Myoglobin and lactate dehydrogenase concentrations were significantly greater following HI compared to HV (P = 0.01-0.02), whereas the lactate response was significantly higher following HV compared to HI (P = 0.003). The growth hormone, cortisol, and insulin responses were significantly greater following HV compared to HI (P = 0.0001-0.04). No significant differences between protocols were observed for the IGF-1 or testosterone response. Intramuscular anabolic signaling analysis revealed a significantly greater (P = 0.03) phosphorylation of IGF-1 receptor at 1H following HV compared to HI. Phosphorylation status of all other signaling proteins including mTOR, p70S6k, and RPS6 were not significantly different between trials. Despite significant differences in markers of muscle damage and the endocrine response following HV and HI, both protocols appeared to elicit similar mTORC1 activation in resistance-trained men.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.