ArticlePLoS genetics2015
Large-Scale Phenomics Identifies Primary and Fine-Tuning Roles for CRKs in Responses Related to Oxidative Stress.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
105 citing papers in PubMed, 1 synthesis or guideline pooled it, 227 citations in OpenAlex.
- Gene regulatory and co-expression networks reveal novel hub genes and regulatory mechanisms in rapeseed (Brassica napus L.) under drought stress.Scientific reports · 2025Pooled it
- CYSTEINE-RICH RLK2 regulates development via callose synthase-dependent symplastic transport in Arabidopsis.Plant physiology · 2026Article
- Defective cuticle-derived signals enhance extracellular ATP response and plant immunity.The New phytologist · 2026Article
- CRK5 preserves antioxidant homeostasis and prevents cell death during dark-induced senescence through inhibiting the salicylic acid signaling pathway.BMC plant biology · 2026Article
- CRK2 modulates flowering in Arabidopsis together with GLYCINE-RICH RNA-BINDING PROTEIN 7.The New phytologist · 2026Article
- Article
- Genetic Diversity, Predictive Protein Structures, and Interaction Networks of Cysteine-Rich Receptor-Like Kinases inComputational and structural biotechnology journal · 2026Article
- Genome-wide association study and genomic prediction of bolting trait in spinach (Frontiers in plant science · 2026Article
- A receptor-like kinase recognizes viral proteins at the trans-Golgi network/early endosome and inhibits infection in rice.Cell discovery · 2025Article
- A retrotransposon insertion upstream of Arabidopsis thaliana CRK8 receptor-like kinase modulates a trade-off between pathogen defense and salt tolerance.The Plant journal : for cell and molecular biology · 2025Article
- CarboTag: a modular approach for live and functional imaging of plant cell walls.Nature methods · 2025Article
- Genomic and Physiological Basis of Structural and Foliar Trait Variation in Tropical SpeciesEvolutionary applications · 2025Article
- More questions than answers: insights into potential cysteine-rich receptor-like kinases redox signalling in Arabidopsis.The Plant journal : for cell and molecular biology · 2025Review
- CaBMC plant biology · 2025Article
- Review
- Insights ofFrontiers in plant science · 2025Article
- ZmHSFA2B self-regulatory loop is critical for heat tolerance in maize.Plant biotechnology journal · 2025Article
- Unravelling alternative splicing patterns in susceptible and resistant Brassica napus lines in response to Xanthomonas campestris infection.BMC plant biology · 2024Article
- Integrated Biological Experiments and Proteomic Analyses ofInternational journal of molecular sciences · 2024Article
- An expanded cysteine-rich receptor-like kinase gene cluster functionally differentiates in drought, cold, heat, and pathogen stress responses in rice.Plant biotechnology journal · 2024Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
34 authors at 9 institutions in 8 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cysteine-rich receptor-like kinases (CRKs) are transmembrane proteins characterized by the presence of two domains of unknown function 26 (DUF26) in their ectodomain. The CRKs form one of the largest groups of receptor-like protein kinases in plants, but their biological functions have so far remained largely uncharacterized. We conducted a large-scale phenotyping approach of a nearly complete crk T-DNA insertion line collection showing that CRKs control important aspects of plant development and stress adaptation in response to biotic and abiotic stimuli in a non-redundant fashion. In particular, the analysis of reactive oxygen species (ROS)-related stress responses, such as regulation of the stomatal aperture, suggests that CRKs participate in ROS/redox signalling and sensing. CRKs play general and fine-tuning roles in the regulation of stomatal closure induced by microbial and abiotic cues. Despite their great number and high similarity, large-scale phenotyping identified specific functions in diverse processes for many CRKs and indicated that CRK2 and CRK5 play predominant roles in growth regulation and stress adaptation, respectively. As a whole, the CRKs contribute to specificity in ROS signalling. Individual CRKs control distinct responses in an antagonistic fashion suggesting future potential for using CRKs in genetic approaches to improve plant performance and stress tolerance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.