Evidence map›Paper›PMID 26197260›Full record

Trial reportContraception2016

An educational intervention on drug interactions and contraceptive options for epilepsy patients: a pilot randomized controlled trial.

Sheila K Mody, Carolyn Haunschild, John Paul Farala, Gordon Honerkamp-Smith, Vivian Hur, Leena Kansal

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Contraception, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Epilepsy: addressing the transition from pediatric to adult care.Adolescent health, medicine and therapeutics · 2016
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Sheila K ModyDepartment of Reproductive Medicine, University of California San Diego, La Jolla, CA 92093, USA. Electronic address: smody@ucsd.edu.
Carolyn HaunschildStanford University School of Medicine, Stanford, CA 94305, USA.
John Paul FaralaUniversity of California San Francisco Medical School, San Francisco, CA 94143, USA.
Gordon Honerkamp-SmithClinical and Translational Research Institute, University of California San Diego, La Jolla, CA 92037, USA.
Vivian HurDepartment of Reproductive Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Leena KansalDepartment of Neurology, University of California San Diego, La Jolla, CA 92093-0662, USA.
University of California, San Diego · USStanford University · USUniversity of California, San Francisco · US

Funding

UC San Diego Womens Reproductive Health Research ProgramK12HD001259 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CYNTHIA GYAMFI-BANNERMAN · 1999 to 2026
$9.1M
NICHD NIH HHS K12 HD001259
6 · The paper itself

Abstract

objectiveThis pilot study investigates whether an educational handout could increase short-term information retention about drug interactions between antiepileptic drugs (AEDs) and hormonal contraceptives among female epilepsy patients of reproductive age. STUDY

designThis is a pilot randomized controlled trial of an educational intervention among reproductive-age women with epilepsy in an academic neurology clinic. Investigators measured knowledge before and after participants received either usual care or the educational handout. The 10-question test assessed increased knowledge of which AEDs affected efficacy of certain hormonal contraceptives and was assessed by calculating the improvement in score between the pretest and posttest. The educational handout included the names of AEDs that have drug interactions with certain contraceptives and the efficacy of the contraceptives.

resultsA total of 42 epilepsy patients participated in this study. Fourteen participants were taking AEDs that are enzyme p450 inducers and 13 participants were taking Lamotrigine. Twenty women were randomized to receive the educational handout and 22 women were randomized to usual care. We found no statistical difference in the groups with regard to age, ethnicity or level of education. We found a significantly higher improvement in quiz scores in the educational handout group (3.65 point increase) compared to the usual care group (0.68 point increase) as calculated by the Student's two-sample t test (p<.001).

conclusionsAn educational handout on drug interactions and contraceptives resulted in increased short-term information retention on this topic among reproductive-age female epilepsy patients. IMPLICATIONS: This pilot study highlights the need for further larger studies to evaluate the impact of educational interventions on improving patient knowledge about the drug interaction of AEDs and hormonal contraceptives.

Indexed as

Health Knowledge, Attitudes, PracticeAdultAnticonvulsantsContraceptives, Oral, HormonalDrug InteractionsEpilepsyFemaleHumansLamotrigineMemory, Short-TermPatient Education as TopicPilot ProjectsRetention, PsychologyTriazinesAnticonvulsantsContraceptives, Oral, HormonalLamotrigineTriazinesContraceptionCounselingDrug interactionsEpilepsy

Identifiers

PMID26197260
PMCPMC4852845
OpenAlexW1989642462

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.