ArticlePloS one2015
A Mathematical Model of Quorum Sensing Induced Biofilm Detachment.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed.
- Using stochastic cellular automata to model and define sufficient conditions for the survival of Enterococcus faecalis biofilms with the pCF10 plasmid under erythromycin treatment.PLoS computational biology · 2025Article
- Examination of the Structure and Formation Streptococcus mutans Biofilm Induced by Glucose, Lactose, Soy Protein, and Iron.European journal of dentistry · 2024Article
- Unveiling bacterial communication with a MATLAB GUI implementing the diffusion-based quorum sensing model.Scientific reports · 2024Article
- Signaling in microbial communities with open boundaries.Biophysical journal · 2023Article
- Pseudomonas aeruginosa's greenish-blue pigment pyocyanin: its production and biological activities.Microbial cell factories · 2023Review
- Signaling in microbial communities with open boundaries.bioRxiv : the preprint server for biology · 2023Article
- Scaling relations for auxin waves.Journal of mathematical biology · 2022Article
- Mutagenic strategies against luxS gene affect the early stage of biofilm formation of Campylobacter jejuni.Journal of applied genetics · 2022Article
- Regulation ofBiofilm · 2021Article
- Modeling of Symbiotic Bacterial Biofilm Growth with an Example of the Streptococcus-Veillonella sp. System.Bulletin of mathematical biology · 2021Article
- Colour Me Blue: The History and the Biotechnological Potential of Pyocyanin.Molecules (Basel, Switzerland) · 2021Review
- Persistence as an Optimal Hedging Strategy.Biophysical journal · 2021Article
- Quorum sensing-induced phenotypic switching as a regulatory nutritional stress response in a competitive two-species biofilm: An individual-based cellular automata model.Journal of biosciences · 2020Article
- Challenges of biofilm control and utilization: lessons from mathematical modelling.Journal of the Royal Society, Interface · 2019Article
- Exploring the transcriptome ofPeerJ · 2019Article
- Human antibody repertoire frequently includes antibodies to a bacterial biofilm associated protein.PloS one · 2019Article
- Information transmission in microbial and fungal communication: from classical to quantum.Journal of cell communication and signaling · 2018Article
- Mesoscopic Energy Minimization Drives Pseudomonas aeruginosa Biofilm Morphologies and Consequent Stratification of Antibiotic Activity Based on Cell Metabolism.Antimicrobial agents and chemotherapy · 2018Article
- Continuum and discrete approach in modeling biofilm development and structure: a review.Journal of mathematical biology · 2018Review
- Detection of Diverse N-Acyl-Homoserine Lactones inFrontiers in microbiology · 2017Article
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4 authors.
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Abstract
backgroundCell dispersal (or detachment) is part of the developmental cycle of microbial biofilms. It can be externally or internally induced, and manifests itself in discrete sloughing events, whereby many cells disperse in an instance, or in continuous slower dispersal of single cells. One suggested trigger of cell dispersal is quorum sensing, a cell-cell communication mechanism used to coordinate gene expression and behavior in groups based on population densities.
methodTo better understand the interplay of colony growth and cell dispersal, we develop a dynamic, spatially extended mathematical model that includes biofilm growth, production of quorum sensing molecules, cell dispersal triggered by quorum sensing molecules, and re-attachment of cells. This is a highly nonlinear system of diffusion-reaction equations that we study in computer simulations.
resultsOur results show that quorum sensing induced cell dispersal can be an efficient mechanism for bacteria to control the size of a biofilm colony, and at the same time enhance its downstream colonization potential. In fact we find that over the lifetime of a biofilm colony the majority of cells produced are lost into the aqueous phase, supporting the notion of biofilms as cell nurseries. We find that a single quorum sensing based mechanism can explain both, discrete dispersal events and continuous shedding of cells from a colony. Moreover, quorum sensing induced cell dispersal affects the structure and architecture of the biofilm, for example it might lead to the formation of hollow inner regions in a biofilm colony.
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