ReviewCurrent opinion in nephrology and hypertension2015
Redox signaling, Nox5 and vascular remodeling in hypertension.
Review in Current opinion in nephrology and hypertension, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
46 citing papers in PubMed, 92 citations in OpenAlex.
- Urolithin A alleviates vascular remodeling through mitochondrial SIRT3-mediated SOD2 deacetylation and antioxidation in hypertensive rats.Redox report : communications in free radical research · 2026Article
- Arachidonic acid is involved in high-salt diet-induced coronary remodeling through stimulation of the IRE1α/XBP1s/RUNX2/OPN signaling cascade.Lipids in health and disease · 2025Article
- Trifolin inhibits the calcium-driven contraction pathway in vascular smooth muscle.Frontiers in pharmacology · 2025Article
- Adherence to dietary approaches to stop hypertension (DASH), Mediterranean diet, and plant-based dietary pattern with systolic and diastolic blood pressure: A cross-sectional analysis.Caspian journal of internal medicine · 2025Article
- Inflammation and Arterial Stiffness as Drivers of Cardiovascular Risk in Kidney Disease.Cardiorenal medicine · 2025Review
- Oxidative Stress and Cytoskeletal Reorganization in Hypertensive Erythrocytes.Antioxidants (Basel, Switzerland) · 2024Article
- Role of EZH2-mediated epigenetic modification on vascular smooth muscle in cardiovascular diseases: A mini-review.Frontiers in pharmacology · 2024Review
- Aortic smooth muscle TRPV4 channels regulate vasoconstriction in high salt-induced hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Oxidative Stress, Antioxidants and Hypertension.Antioxidants (Basel, Switzerland) · 2023Review
- Extracellular vesicles in vascular remodeling.Acta pharmacologica Sinica · 2022Review
- Ferroptosis: A Potential Therapeutic Target in Acute Kidney Injury.International journal of molecular sciences · 2022Review
- Mitochondrial Metabolism, Redox, and Calcium Homeostasis in Pulmonary Arterial Hypertension.Biomedicines · 2022Review
- Effects of different intensities of continuous training on vascular inflammation and oxidative stress in spontaneously hypertensive rats.Journal of cellular and molecular medicine · 2021Article
- Intratubular, Intracellular, and Mitochondrial Angiotensin II/ATFrontiers in physiology · 2021Review
- Endogenous hydrogen sulfide improves vascular remodeling through PPARδ/SOCS3 signaling.Journal of advanced research · 2021Review
- Molecular and Cellular Mechanisms Associated with Effects of Molecular Hydrogen in Cardiovascular and Central Nervous Systems.Antioxidants (Basel, Switzerland) · 2020Review
- Importance of cholesterol-rich microdomains in the regulation of Nox isoforms and redox signaling in human vascular smooth muscle cells.Scientific reports · 2020Article
- The correlation of IRE1α oxidation with Nox4 activation in aging-associated vascular dysfunction.Redox biology · 2020Article
- Vascular consequences of inflammation: a position statement from the ESH Working Group on Vascular Structure and Function and the ARTERY Society.Journal of hypertension · 2020Review
- Vasculoprotective effects ofJournal of traditional and complementary medicine · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
purpose of reviewExtensive data indicate a role for reactive oxygen species (ROS) and redox signaling in vascular damage in hypertension. However, molecular mechanisms underlying these processes remain unclear, but oxidative post-translational modification of vascular proteins is critical. This review discusses how proteins are oxidatively modified and how redox signaling influences vascular smooth muscle cell growth and vascular remodeling in hypertension. We also highlight Nox5 as a novel vascular ROS-generating oxidase. RECENT
findingsOxidative stress in hypertension leads to oxidative imbalance that affects vascular cell function through redox signaling. Many Nox isoforms produce ROS in the vascular wall, and recent findings show that Nox5 may be important in humans. ROS regulate signaling by numerous processes including cysteine oxidative post-translational modification such as S-nitrosylation, S-glutathionylation and sulfydration. In vascular smooth muscle cells, this influences cellular responses to oxidative stimuli promoting changes from a contractile to a proliferative phenotype. SUMMARY: In hypertension, Nox-induced ROS production is increased, leading to perturbed redox signaling through oxidative modifications of vascular proteins. This influences mitogenic signaling and cell cycle regulation, leading to altered cell growth and vascular remodeling in hypertension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.