ArticlePloS one2015
Abnormal Social Reward Responses in Anorexia Nervosa: An fMRI Study.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The vicious circle of social exclusion and psychopathology: a systematic review of experimental ostracism research in psychiatric disorders.European archives of psychiatry and clinical neuroscience · 2020Pooled it
- Moving towards specificity: A systematic review of cue features associated with reward and punishment in anorexia nervosa.Clinical psychology review · 2020Pooled it
- Neural correlates of social exclusion across ages: A coordinate-based meta-analysis of functional MRI studies.NeuroImage · 2017Pooled it
- Social rejection sensitivity and its role in anorexia nervosa: a systematic review of experimental literature.Journal of eating disorders · 2025Review
- Social Processing in Eating Disorders: Neuroimaging Paradigms and Research Domain Organizational Constructs.Current psychiatry reports · 2022Review
- Aberrant neural representation of food stimuli in women with acute anorexia nervosa predicts treatment outcome and is improved in weight restored individuals.Translational psychiatry · 2021Article
- Critical incidents in anorexia nervosa: perspectives of those with a lived experience.Journal of eating disorders · 2021Article
- Exploring Neural Mechanisms Related to Cognitive Control, Reward, and Affect in Eating Disorders: A Narrative Review of FMRI Studies.Neuropsychiatric disease and treatment · 2021Review
- Computer-aided therapeutic diagnosis for anorexia.Biomedical engineering online · 2020Article
- Neural correlates of negative expectancy and impaired social feedback processing in social anxiety.Social cognitive and affective neuroscience · 2020Article
- Neural Processing of Disorder-Related Stimuli in Patients with Anorexia Nervosa: A Narrative Review of Brain Imaging Studies.Journal of clinical medicine · 2019Review
- The reduction of astrocytes and brain volume loss in anorexia nervosa-the impact of starvation and refeeding in a rodent model.Translational psychiatry · 2019Article
- A Transdiagnostic Perspective on Social Anhedonia.Frontiers in psychiatry · 2019Review
- Article
- The real-life costs of emotion regulation in anorexia nervosa: a combined ecological momentary assessment and fMRI study.Translational psychiatry · 2018Article
- Neurobiology of social reward valuation in adults with a history of anorexia nervosa.PloS one · 2018Article
- Social Difficulties As Risk and Maintaining Factors in Anorexia Nervosa: A Mixed-Method Investigation.Frontiers in psychiatry · 2018Article
- Neural Network Alterations Across Eating Disorders: A Narrative Review of fMRI Studies.Current neuropharmacology · 2018Review
- Hemispheric lateralization of resting-state functional connectivity of the ventral striatum: an exploratory study.Brain structure & function · 2017Article
- Functional brain alterations in anorexia nervosa: a scoping review.Journal of eating disorders · 2016Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with anorexia nervosa (AN) display impaired social interactions, implicated in the development and prognosis of the disorder. Importantly, social behavior is modulated by reward-based processes, and dysfunctional at-brain-level reward responses have been involved in AN neurobiological models. However, no prior evidence exists of whether these neural alterations would be equally present in social contexts. In this study, we conducted a cross-sectional social-judgment functional magnetic resonance imaging (fMRI) study of 20 restrictive-subtype AN patients and 20 matched healthy controls. Brain activity during acceptance and rejection was investigated and correlated with severity measures (Eating Disorder Inventory -EDI-2) and with personality traits of interest known to modulate social behavior (The Sensitivity to Punishment and Sensitivity to Reward Questionnaire). Patients showed hypoactivation of the dorsomedial prefrontal cortex (DMPFC) during social acceptance and hyperactivation of visual areas during social rejection. Ventral striatum activation during rejection was positively correlated in patients with clinical severity scores. During acceptance, activation of the frontal opercula-anterior insula and dorsomedial/dorsolateral prefrontal cortices was differentially associated with reward sensitivity between groups. These results suggest an abnormal motivational drive for social stimuli, and involve overlapping social cognition and reward systems leading to a disruption of adaptive responses in the processing of social reward. The specific association of reward-related regions with clinical and psychometric measures suggests the putative involvement of reward structures in the maintenance of pathological behaviors in AN.
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