Evidence map›Paper›PMID 26196951›Full record

ArticleThe Journal of clinical endocrinology and metabolism2015

Vitamin D Associations With Renal, Bone, and Cardiovascular Phenotypes: African American-Diabetes Heart Study.

Barry I Freedman, Jasmin Divers, Gregory B Russell, Nicholette D Palmer, Lynne E Wagenknecht, S Carrie Smith, Jianzhao Xu, J Jeffrey Carr, Donald W Bowden, Thomas C Register

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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  3. Volumetric bone mineral density of the spine predicts mortality in African-American men with type 2 diabetes.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Barry I FreedmanDepartment of Internal Medicine, Section on Nephrology (B.I.F.), Center for Genomics and Personalized Medicine Research (B.I.F., J.D., G.B.R., N.D.P., J.X., D.W.B.), Center for Diabetes Research (B.I.F. J.D., G.B.R., N.D.P., L.E.W., J.X.), Center for Public Health Genomics (B.I.F. J.D., G.B.R., N.D.P., D.W.B.), Division of Public Health Sciences-Department of Biostatistical Sciences (J.D., G.B.R., L.E.W.), Department of Biochemistry (N.D.P., S.C.S., J.X.), and Department of Pathology (T.C.R.), Wake Forest School of Medicine, Winston-Salem, NC 27157; and Department of Radiology (J.J.C.), Vanderbilt University School of Medicine, Nashville, TN 37240.
Jasmin DiversDepartment of Internal Medicine, Section on Nephrology (B.I.F.), Center for Genomics and Personalized Medicine Research (B.I.F., J.D., G.B.R., N.D.P., J.X., D.W.B.), Center for Diabetes Research (B.I.F. J.D., G.B.R., N.D.P., L.E.W., J.X.), Center for Public Health Genomics (B.I.F. J.D., G.B.R., N.D.P., D.W.B.), Division of Public Health Sciences-Department of Biostatistical Sciences (J.D., G.B.R., L.E.W.), Department of Biochemistry (N.D.P., S.C.S., J.X.), and Department of Pathology (T.C.R.), Wake Forest School of Medicine, Winston-Salem, NC 27157; and Department of Radiology (J.J.C.), Vanderbilt University School of Medicine, Nashville, TN 37240.
Gregory B RussellDepartment of Internal Medicine, Section on Nephrology (B.I.F.), Center for Genomics and Personalized Medicine Research (B.I.F., J.D., G.B.R., N.D.P., J.X., D.W.B.), Center for Diabetes Research (B.I.F. J.D., G.B.R., N.D.P., L.E.W., J.X.), Center for Public Health Genomics (B.I.F. J.D., G.B.R., N.D.P., D.W.B.), Division of Public Health Sciences-Department of Biostatistical Sciences (J.D., G.B.R., L.E.W.), Department of Biochemistry (N.D.P., S.C.S., J.X.), and Department of Pathology (T.C.R.), Wake Forest School of Medicine, Winston-Salem, NC 27157; and Department of Radiology (J.J.C.), Vanderbilt University School of Medicine, Nashville, TN 37240.
Nicholette D PalmerDepartment of Internal Medicine, Section on Nephrology (B.I.F.), Center for Genomics and Personalized Medicine Research (B.I.F., J.D., G.B.R., N.D.P., J.X., D.W.B.), Center for Diabetes Research (B.I.F. J.D., G.B.R., N.D.P., L.E.W., J.X.), Center for Public Health Genomics (B.I.F. J.D., G.B.R., N.D.P., D.W.B.), Division of Public Health Sciences-Department of Biostatistical Sciences (J.D., G.B.R., L.E.W.), Department of Biochemistry (N.D.P., S.C.S., J.X.), and Department of Pathology (T.C.R.), Wake Forest School of Medicine, Winston-Salem, NC 27157; and Department of Radiology (J.J.C.), Vanderbilt University School of Medicine, Nashville, TN 37240.
Lynne E WagenknechtDepartment of Internal Medicine, Section on Nephrology (B.I.F.), Center for Genomics and Personalized Medicine Research (B.I.F., J.D., G.B.R., N.D.P., J.X., D.W.B.), Center for Diabetes Research (B.I.F. J.D., G.B.R., N.D.P., L.E.W., J.X.), Center for Public Health Genomics (B.I.F. J.D., G.B.R., N.D.P., D.W.B.), Division of Public Health Sciences-Department of Biostatistical Sciences (J.D., G.B.R., L.E.W.), Department of Biochemistry (N.D.P., S.C.S., J.X.), and Department of Pathology (T.C.R.), Wake Forest School of Medicine, Winston-Salem, NC 27157; and Department of Radiology (J.J.C.), Vanderbilt University School of Medicine, Nashville, TN 37240.
S Carrie SmithDepartment of Internal Medicine, Section on Nephrology (B.I.F.), Center for Genomics and Personalized Medicine Research (B.I.F., J.D., G.B.R., N.D.P., J.X., D.W.B.), Center for Diabetes Research (B.I.F. J.D., G.B.R., N.D.P., L.E.W., J.X.), Center for Public Health Genomics (B.I.F. J.D., G.B.R., N.D.P., D.W.B.), Division of Public Health Sciences-Department of Biostatistical Sciences (J.D., G.B.R., L.E.W.), Department of Biochemistry (N.D.P., S.C.S., J.X.), and Department of Pathology (T.C.R.), Wake Forest School of Medicine, Winston-Salem, NC 27157; and Department of Radiology (J.J.C.), Vanderbilt University School of Medicine, Nashville, TN 37240.
Jianzhao XuDepartment of Internal Medicine, Section on Nephrology (B.I.F.), Center for Genomics and Personalized Medicine Research (B.I.F., J.D., G.B.R., N.D.P., J.X., D.W.B.), Center for Diabetes Research (B.I.F. J.D., G.B.R., N.D.P., L.E.W., J.X.), Center for Public Health Genomics (B.I.F. J.D., G.B.R., N.D.P., D.W.B.), Division of Public Health Sciences-Department of Biostatistical Sciences (J.D., G.B.R., L.E.W.), Department of Biochemistry (N.D.P., S.C.S., J.X.), and Department of Pathology (T.C.R.), Wake Forest School of Medicine, Winston-Salem, NC 27157; and Department of Radiology (J.J.C.), Vanderbilt University School of Medicine, Nashville, TN 37240.
J Jeffrey CarrDepartment of Internal Medicine, Section on Nephrology (B.I.F.), Center for Genomics and Personalized Medicine Research (B.I.F., J.D., G.B.R., N.D.P., J.X., D.W.B.), Center for Diabetes Research (B.I.F. J.D., G.B.R., N.D.P., L.E.W., J.X.), Center for Public Health Genomics (B.I.F. J.D., G.B.R., N.D.P., D.W.B.), Division of Public Health Sciences-Department of Biostatistical Sciences (J.D., G.B.R., L.E.W.), Department of Biochemistry (N.D.P., S.C.S., J.X.), and Department of Pathology (T.C.R.), Wake Forest School of Medicine, Winston-Salem, NC 27157; and Department of Radiology (J.J.C.), Vanderbilt University School of Medicine, Nashville, TN 37240.
Donald W BowdenDepartment of Internal Medicine, Section on Nephrology (B.I.F.), Center for Genomics and Personalized Medicine Research (B.I.F., J.D., G.B.R., N.D.P., J.X., D.W.B.), Center for Diabetes Research (B.I.F. J.D., G.B.R., N.D.P., L.E.W., J.X.), Center for Public Health Genomics (B.I.F. J.D., G.B.R., N.D.P., D.W.B.), Division of Public Health Sciences-Department of Biostatistical Sciences (J.D., G.B.R., L.E.W.), Department of Biochemistry (N.D.P., S.C.S., J.X.), and Department of Pathology (T.C.R.), Wake Forest School of Medicine, Winston-Salem, NC 27157; and Department of Radiology (J.J.C.), Vanderbilt University School of Medicine, Nashville, TN 37240.
Thomas C RegisterDepartment of Internal Medicine, Section on Nephrology (B.I.F.), Center for Genomics and Personalized Medicine Research (B.I.F., J.D., G.B.R., N.D.P., J.X., D.W.B.), Center for Diabetes Research (B.I.F. J.D., G.B.R., N.D.P., L.E.W., J.X.), Center for Public Health Genomics (B.I.F. J.D., G.B.R., N.D.P., D.W.B.), Division of Public Health Sciences-Department of Biostatistical Sciences (J.D., G.B.R., L.E.W.), Department of Biochemistry (N.D.P., S.C.S., J.X.), and Department of Pathology (T.C.R.), Wake Forest School of Medicine, Winston-Salem, NC 27157; and Department of Radiology (J.J.C.), Vanderbilt University School of Medicine, Nashville, TN 37240.
North Carolina Division of Public Health · USVanderbilt University · USWake Forest University · USWinston-Salem/Forsyth County Schools · US

Funding

WORKER PROTECTION AGAINST AIRBORNE INFLUENZA - A PILOT STUDYM01RR007122 · NCRR · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HUNDLEY, WILLIAM GREGORY · 1992 to 2010
$35.2M
Subclinical CVD in African American Type 2 DiabeticsR01DK071891 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI FREEDMAN, BARRY IRA · 2007 to 2016
$4.5M
Whole Genome Association Analysis of the Diabetes Heart StudyR01HL092301 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BOWDEN, DONALD W · 2010 to 2013
$2.7M
NCRR NIH HHS M01 RR007122NCRR NIH HHS MO1-RR-07122NHLBI NIH HHS R01 HL092301NIDDK NIH HHS R01 DK071891
6 · The paper itself

Abstract

contextVitamin D binding protein (DBP) is an important determinant of bioavailable vitamin D (BAVD) and may provide clues to racial variation in osteoporosis and atherosclerosis.

objectiveThe objective was to assess relationships between DBP, BAVD, 25-hydroxyvitamin D (25OHD), and 1,25 di-hydroxyvitamin D (1,25OH2D) with kidney, bone, adipose, and atherosclerosis phenotypes in African Americans with type 2 diabetes.

designCross-sectional (N = 545) and longitudinal (N = 288; mean 5.1 ± 0.9-year follow-up) relationships between vitamin D concentrations with renal phenotypes, vertebral bone mineral density, aorto-iliac, coronary artery, and carotid artery calcified plaque (CP), and adipose tissue volumes were studied.

settingAfrican American-Diabetes Heart Study. PATIENTS: Participants were 56.7% female with mean ± standard deviation (sd) age 55.6 ± 9.6 years, diabetes duration 10.3 ± 8.2 years, and eGFR 90.9 ± 22.1 ml/min/1.73 m(2).

interventionsNone. MAIN OUTCOMES AND MEASURES: Associations tested between vitamin D and the previously mentioned phenotypes adjusting for age, sex, African ancestry proportion, diabetes duration, statins, smoking, changes in estimated glomerular filtration rate, body mass index, hemoglobin A1c, and blood pressure.

results1,25OH2D was inversely associated with change in coronary artery CP (parameter estimate [β] -0.005, standard error [SE] 0.002; P = .037), with a trend for change in carotid artery CP (β -0.007, SE 0.004; P = .074). Further adjustment for renin-aldosterone-system blockade revealed inverse association between 1,25OH2D and change in albuminuria (β -0.004, SE 0.002; P = .037). DBP, BAVD, and 25OHD did not associate significantly with changes in albuminuria, CP, or bone mineral density. BAVD was inversely associated with visceral, subcutaneous, intermuscular, and pericardial adipose volumes.

conclusionsIn contrast to BAVD and 25OHD, only 1,25OH2D levels were significantly and inversely associated with changes in subclinical atherosclerosis and albuminuria in African Americans, suggesting potential beneficial effects.

Indexed as

AgedAlbuminuriaAtherosclerosisBlack or African AmericanBone DensityCross-Sectional StudiesDiabetes Mellitus, Type 2FemaleHumansMaleMiddle AgedVitamin DVitamin D-Binding Protein1,25-dihydroxyvitamin D25-hydroxyvitamin DVitamin DVitamin D-Binding Protein

Identifiers

PMID26196951
PMCPMC4596046
OpenAlexW1887036574

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.