ArticlePloS one2015
Pesticide Use and Relative Leukocyte Telomere Length in the Agricultural Health Study.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Integrating epidemiological and bioinformatics analyses identified the effects of organophosphate pesticides accelerating biological aging.International journal of surgery (London, England) · 2025Article
- Occupational pesticide use and relative leukocyte telomere length in the biomarkers of exposure and effect in agriculture study.Environmental research · 2025Article
- Inverse and Direct Effect of Serum DDE Exposure on the Distribution of Leukocyte Telomere Length in Brazilian Adults: The Pró-Saúde Study.Journal of health & pollution · 2024Article
- Genome-wide analysis of sex-specific differences in the mother-child PELAGIE cohort exposed to organophosphate metabolites.Scientific reports · 2023Article
- Monitoring residues of pesticides in food in Brazil: A multiscale analysis of the main contaminants, dietary cancer risk estimative and mechanisms associated.Frontiers in public health · 2023Article
- Exposure to Airborne Pesticides and Its Residue in Blood Serum of Paddy Farmers in Malaysia.International journal of environmental research and public health · 2022Article
- Article
- Different working conditions shift the genetic damage levels of pesticide-exposed agriculture workers.Environmental science and pollution research international · 2020Article
- Systems Genetics and Systems Biology Analysis of Paraquat Neurotoxicity in BXD Recombinant Inbred Mice.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- Molecular and epigenetic markers as promising tools to quantify the effect of occupational exposures and the risk of developing non-communicable diseases.La Medicina del lavoro · 2019Article
- High Pesticide Exposure Events and Olfactory Impairment among U.S. Farmers.Environmental health perspectives · 2019Article
- Lifetime Pesticide Use and Antinuclear Antibodies in Male Farmers From the Agricultural Health Study.Frontiers in immunology · 2019Article
- Alachlor Use and Cancer Incidence in the Agricultural Health Study: An Updated Analysis.Journal of the National Cancer Institute · 2018Article
- Occupational Exposure to Pesticides in Tobacco Fields: The Integrated Evaluation of Nutritional Intake and Susceptibility on Genomic and Epigenetic Instability.Oxidative medicine and cellular longevity · 2018Article
- Beginning at the ends: telomeres and human disease.F1000Research · 2018Review
- Environmental Chemicals and Aging.Current environmental health reports · 2017Review
- A single method for detecting 11 organophosphate pesticides in human plasma and breastmilk using GC-FPD.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2016Article
- Adverse outcome pathways: From research to regulation scientific workshop report.Regulatory toxicology and pharmacology : RTP · 2016Article
- Polychlorinated Biphenyls and Cancer: Are Telomeres to Blame?EBioMedicine · 2015Article
- The Biomarkers of Exposure and Effect in Agriculture (BEEA) Study: Rationale, Design, Methods, and Participant Characteristics.Journal of toxicology and environmental health. Part A · 2015Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Some studies suggest that telomere length (TL) may be influenced by environmental exposures, including pesticides. We examined associations between occupational pesticide use reported at three time points and relative telomere length (RTL) in the Agricultural Health Study (AHS), a prospective cohort study of pesticide applicators in Iowa and North Carolina. RTL was measured by qPCR using leukocyte DNA from 568 cancer-free male AHS participants aged 31-94 years with blood samples collected between 2006 and 2008. Self-reported information, including pesticide use, was collected at three time points: enrollment (1993-1997) and two follow-up questionnaires (1998-2003, 2005-2008). For each pesticide, we evaluated cumulative use (using data from all three questionnaires), and more recent use (using data from the last follow-up questionnaire). Multivariable linear regression was used to examine the associations between pesticide use (ever, lifetime days, intensity-weighted lifetime days (lifetime days*intensity score)) and RTL, adjusting for age at blood draw and use of other pesticides. Of the 57 pesticides evaluated with cumulative use, increasing lifetime days of 2,4-D (p-trend=0.001), diazinon (p-trend=0.002), and butylate (p-trend=0.01) were significantly associated with shorter RTL, while increasing lifetime days of alachlor was significantly associated with longer RTL (p-trend=0.03). Only the association with 2,4-D was significant after adjustment for multiple comparisons. Of the 40 pesticides evaluated for recent use, malathion was associated with shorter RTL (p=0.03), and alachlor with longer RTL (p=0.03). Our findings suggest that leukocyte TL may be impacted by cumulative use and recent use of certain pesticides.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.