ArticleShock (Augusta, Ga.)2015
Skeletal Muscle Loss is Associated with TNF Mediated Insufficient Skeletal Myogenic Activation After Burn.
Article in Shock (Augusta, Ga.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 38 citations in OpenAlex.
- Mild burn amplifies the locomotive depression in demyelinated mice without muscle pathophysiological changes.PloS one · 2024Article
- Acute muscle mass loss was alleviated with HMGB1 neutralizing antibody treatment in severe burned rats.Scientific reports · 2023Article
- Molecular mechanisms of post-burn muscle wasting and the therapeutic potential of physical exercise.Journal of cachexia, sarcopenia and muscle · 2023Review
- Skeletal muscle transcriptome is affected by age in severely burned mice.Scientific reports · 2022Article
- Molecular imbalance mechanism of skin and blood leucocytes in severe burn patients at different burn times.Annals of translational medicine · 2022Article
- C188-9, a specific inhibitor of STAT3 signaling, prevents thermal burn-induced skeletal muscle wasting in mice.Frontiers in pharmacology · 2022Article
- Skeletal muscle wasting after a severe burn is a consequence of cachexia and sarcopenia.JPEN. Journal of parenteral and enteral nutrition · 2021Review
- Burn-induced hypermetabolism and skeletal muscle dysfunction.American journal of physiology. Cell physiology · 2021Review
- Aging of the immune system and impaired muscle regeneration: A failure of immunomodulation of adult myogenesis.Experimental gerontology · 2021Review
- Cancer-Associated Muscle Wasting-Candidate Mechanisms and Molecular Pathways.International journal of molecular sciences · 2020Review
- Erythropoietin Alleviates Burn-induced Muscle Wasting.International journal of medical sciences · 2020Article
- Molecular Mechanisms Responsible for the Rescue Effects of Pamidronate on Muscle Atrophy in Pediatric Burn Patients.Frontiers in endocrinology · 2019Article
- Myeloid cell-derived tumor necrosis factor-alpha promotes sarcopenia and regulates muscle cell fusion with aging muscle fibers.Aging cell · 2018Article
- Severe Burn-Induced Inflammation and Remodeling of Achilles Tendon in a Rat Model.Shock (Augusta, Ga.) · 2018Article
- The Role of Calcium in Inflammation-Associated Bone Resorption.Biomolecules · 2018Review
- Synthetic matrix enhances transplanted satellite cell engraftment in dystrophic and aged skeletal muscle with comorbid trauma.Science advances · 2018Article
- Shedding of the endothelial glycocalyx is quantitatively proportional to burn injury severity.Annals of burns and fire disasters · 2018Article
- Inducible satellite cell depletion attenuates skeletal muscle regrowth following a scald-burn injury.The Journal of physiology · 2017Article
- Altered satellite cell dynamics accompany skeletal muscle atrophy during chronic illness, disuse, and aging.Current opinion in clinical nutrition and metabolic care · 2017Review
- The response of muscle progenitor cells to cutaneous thermal injury.Stem cell research & therapy · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Muscle loss accompanies severe burn; in this hyper-catabolic state, muscle undergoes atrophy through protein degradation and disuse. Muscle volume is related to the relative rates of cellular degradation and myogenesis. We hypothesize that muscle atrophy after injury is in part because of insufficient myogenesis associated with the hyper-inflammatory response. The aim of this study was to investigate the role of skeletal myogenesis and muscle cell homeostasis in response to severe burn. Twenty-eight male C57BL6 mice received 25% TBSA scald. Gluteus muscle from these animals was analyzed at days 1, 3, 7, and 14 after injury. Six additional animals without burn served as controls. We showed muscle wet weight and protein content decreased at days 3 and 7 after burn, with elevated tumor necrosis factor (TNF) mRNA expression (P < 0.05). Increased cell death was observed through TUNEL staining, and cleaved caspase-3 levels reached a peak in muscle lysate at day 3 (P < 0.05). The cell proliferation marker proliferating cell nuclear antigen (PCNA) significantly increased after burn, associated with increased gene and protein expression of myogenesis markers Pax7 and myogenin. Desmin mRNA expression and the ratio of desmin to PCNA protein expression, however, significantly decreased at day 7 (P < 0.05). In vitro, the ratio of desmin to PCNA protein expression significantly decreased in C2C12 murine myoblasts after TNF-α stimulation for 24 h. We showed that severe burn induces both increased cell death and proliferation. Myogenesis, however, does not counterbalance increased cell death after burn. Data suggest insufficient myogenesis might be associated with pro-inflammatory mediator TNF activity.
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Registered trials
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