ArticleNeuroImage2015
Affective state and locus of control modulate the neural response to threat.
Article in NeuroImage, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed.
- Trauma From the Eye of the Beholder: Reporter Discordance in Children's Trauma, Psychopathology, and Neurobiology.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Resting-State Neural Signatures of Moral Injury: Associations With Rumination.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Social media usage and cyberbullying: the moderating role of tie strength.Frontiers in psychology · 2025Article
- Perceived control, loneliness, early-life stress, and parents' perceptions of stress.Scientific reports · 2023Article
- Sex-related differences in violence exposure, neural reactivity to threat, and mental health.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Stress-Induced Changes in Effective Connectivity During Regulation of the Emotional Response to Threat.Brain connectivity · 2022Article
- Early life stress and neural development: Implications for understanding the developmental effects of COVID-19.Cognitive, affective & behavioral neuroscience · 2022Review
- Acute Posttraumatic Symptoms Are Associated With Multimodal Neuroimaging Structural Covariance Patterns: A Possible Role for the Neural Substrates of Visual Processing in Posttraumatic Stress Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
- Thinking Clearly About Biology and Childhood Adversity: Next Steps for Continued Progress.Perspectives on psychological science : a journal of the Association for Psychological Science · 2021Article
- Thalamic volume and fear extinction interact to predict acute posttraumatic stress severity.Journal of psychiatric research · 2021Observational
- A large-scale study of stress, emotions, and blood pressure in daily life using a digital platform.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Internality and the internalisation of failure: Evidence from a novel task.PLoS computational biology · 2021Article
- Sex-related Differences in Stress Reactivity and Cingulum White Matter.Neuroscience · 2021Article
- Rethinking Concepts and Categories for Understanding the Neurodevelopmental Effects of Childhood Adversity.Perspectives on psychological science : a journal of the Association for Psychological Science · 2021Article
- The Interplay Between Affective Processing and Sense of Agency During Action Regulation: A Review.Frontiers in psychology · 2021Review
- Early life stress and development: potential mechanisms for adverse outcomes.Journal of neurodevelopmental disorders · 2020Review
- How developmental neuroscience can help address the problem of child poverty.Development and psychopathology · 2020Article
- Negative life experiences contribute to racial differences in the neural response to threat.NeuroImage · 2019Article
- Naltrexone Acutely Enhances Connectivity Between the Ventromedial Prefrontal Cortex and a Left Frontoparietal Network.Alcoholism, clinical and experimental research · 2019Article
- Anticipatory prefrontal cortex activity underlies stress-induced changes in Pavlovian fear conditioning.NeuroImage · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The ability to regulate the emotional response to threat is critical to healthy emotional function. However, the response to threat varies considerably from person-to-person. This variability may be partially explained by differences in emotional processes, such as locus of control and affective state, which vary across individuals. Although the basic neural circuitry that mediates the response to threat has been described, the impact individual differences in affective state and locus of control have on that response is not well characterized. Understanding how these factors influence the neural response to threat would provide new insight into processes that mediate emotional function. Therefore, the present study used a Pavlovian conditioning procedure to investigate the influence individual differences in locus of control, positive affect, and negative affect have on the brain and behavioral responses to predictable and unpredictable threats. Thirty-two healthy volunteers participated in a fear conditioning study in which predictable and unpredictable threats (i.e., unconditioned stimulus) were presented during functional magnetic resonance imaging (fMRI). Locus of control showed a linear relationship with learning-related ventromedial prefrontal cortex (PFC) activity such that the more external an individual's locus of control, the greater their differential response to predictable versus unpredictable threat. In addition, positive and negative affectivity showed a curvilinear relationship with dorsolateral PFC, dorsomedial PFC, and insula activity, such that those with high or low affectivity showed reduced regional activity compared to those with an intermediate level of affectivity. Further, activity within the PFC, as well as other regions including the amygdala, were linked with the peripheral emotional response as indexed by skin conductance and electromyography. The current findings demonstrate that the neural response to threat within brain regions that mediate the peripheral emotional response is modulated by an individual's affective state as well as their perceptions of an event's causality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.