ArticleNeuroImage2015
Resting spontaneous activity in the default mode network predicts performance decline during prolonged attention workload.
Article in NeuroImage, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Mental fatigue and brain activation using prolonged task-based fMRI: a systematic review on time-on-task and sequential task paradigms.Experimental brain research · 2026Pooled it
- State-dependent dual-site prefrontal TMS bidirectionally modulates working-memory accuracy.Frontiers in human neuroscience · 2026Article
- A New Method for Inducing Mental Fatigue: A High Mental Workload Task Paradigm Based on Complex Cognitive Abilities and Time Pressure.Brain sciences · 2025Article
- Time-dependent consolidation mechanisms of durable memory in spaced learning.Communications biology · 2025Article
- Effects of ASMR on mental fatigue recovery revealed by EEG power and brain network analysis.Frontiers in human neuroscience · 2025Article
- Brain endurance training as a strategy for reducing mental fatigue.Frontiers in psychology · 2025Article
- Resting-State Functional Networks Correlate with Motor Performance in a Complex Visuomotor Task: An EEG Microstate Pilot Study on Healthy Individuals.Brain topography · 2024Article
- Structural neural correlates of mental fatigue and reward-induced improvement in performance.Biologia futura · 2024Article
- Increased posterior cingulate cortex blood flow in cancer-related fatigue.Frontiers in neurology · 2023Article
- Life Habits and Mental Health: Behavioural Addiction, Health Benefits of Daily Habits, and the Reward System.Frontiers in psychiatry · 2022Review
- Effects of Caffeine Intake on Cognitive Performance Related to Total Sleep Deprivation and Time on Task: A Randomized Cross-Over Double-Blind Study.Nature and science of sleep · 2022Article
- Imaging cognitive fatigability in multiple sclerosis: objective quantification of cerebral blood flow during a task of sustained attention using ASL perfusion fMRI.Brain imaging and behavior · 2020Article
- Psychological resilience is correlated with dynamic changes in functional connectivity within the default mode network during a cognitive task.Scientific reports · 2020Article
- Loss of frontal regulator of vigilance during sleep inertia: A simultaneous EEG-fMRI study.Human brain mapping · 2020Article
- Impaired Coupling of the Brain's Default Network During Sleep Deprivation: A Resting-State EEG Study.Nature and science of sleep · 2020Article
- Monitoring of fatigue in radiologists during prolonged image interpretation using fNIRS.Japanese journal of radiology · 2019Article
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- Exercise challenge alters Default Mode Network dynamics in Gulf War Illness.BMC neuroscience · 2019Article
- Individual Differences in the Neural Basis of Response Inhibition After Sleep Deprivation Are Mediated by Chronotype.Frontiers in neurology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
After continuous and prolonged cognitive workload, people typically show reduced behavioral performance and increased feelings of fatigue, which are known as "time-on-task (TOT) effects". Although TOT effects are pervasive in modern life, their underlying neural mechanisms remain elusive. In this study, we induced TOT effects by administering a 20-min continuous psychomotor vigilance test (PVT) to a group of 16 healthy adults and used resting-state blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) to examine spontaneous brain activity changes associated with fatigue and performance. Behaviorally, subjects displayed robust TOT effects, as reflected by increasingly slower reaction times as the test progressed and higher self-reported mental fatigue ratings after the 20-min PVT. Compared to pre-test measurements, subjects exhibited reduced amplitudes of low-frequency fluctuation (ALFF) in the default mode network (DMN) and increased ALFF in the thalamus after the test. Subjects also exhibited reduced anti-correlations between the posterior cingulate cortex (PCC) and right middle prefrontal cortex after the test. Moreover, pre-test resting ALFF in the PCC and medial prefrontal cortex (MePFC) predicted subjects' subsequent performance decline; individuals with higher ALFF in these regions exhibited more stable reaction times throughout the 20-min PVT. These results support the important role of both task-positive and task-negative networks in mediating TOT effects and suggest that spontaneous activity measured by resting-state BOLD fMRI may be a marker of mental fatigue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.