ArticleEndocrinology2015
Impact of Reduced ATGL-Mediated Adipocyte Lipolysis on Obesity-Associated Insulin Resistance and Inflammation in Male Mice.
Abstract read
In one paragraph
Article in Endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers.
0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
119 citing papers in PubMed, 181 citations in OpenAlex.
- Pancreatic triglyceride lipase mediates lipotoxic systemic inflammation.The Journal of clinical investigation · 2020Trial
- Adipose Tissue-Central Nervous System Axis in Obesity: Molecular Mechanisms, Inflammation, and Nutritional and Technological Implications.Metabolites · 2026Review
- Mitochondrial calcium regulates lipid metabolism by modulating tethering of mitochondria to lipid droplets.The EMBO journal · 2026Article
- Lipolysis in Health and Disease: Pathways, Regulation, and Metabolic Consequences.Current diabetes reports · 2026Review
- Fatty acid scavenging enables cancer escape from KRAS inhibition.bioRxiv : the preprint server for biology · 2026Article
- ATGL-catalyzed biosynthesis mediates the upregulation of fatty acid hydroxy fatty acids (FAHFA) levels in white adipose tissue with fasting.The Journal of biological chemistry · 2026Article
- ATGL From iWAT and BAT Is Crucial for Cardiac Remodeling and Metabolism After Myocardial Ischemia/Reperfusion.Comprehensive Physiology · 2026Article
- Cytosolic Versus Lysosomal Lipolysis in Adipose Tissue: Opposing Roles in Cardiometabolic Disease.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Targeted regulation of adipose tissue macrophages from an immunometabolic perspective: a novel therapeutic approach for obesity-related metabolic disorders.Frontiers in immunology · 2026Review
- Resveratrol and caffeic acid attenuate diet-induced obesity by inhibiting the SREBP-1/ACLY lipogenic axis in adipose tissue of rats.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2025Article
- Adipose microsomal triglyceride transfer protein deficiency protects against hepatic steatosis by upregulating PPARα activity.JHEP reports : innovation in hepatology · 2025Article
- The regulation of fatty acid mobilization is extravagant rather than frugal: a perspective indicating a limitation of the thrifty genotype hypothesis.The American journal of clinical nutrition · 2025Review
- Microemulsion-based drug delivery system identifies pepper alkaloids as anti-obesity compounds.Acta pharmacologica Sinica · 2025Article
- Absence of the intracellular lipolytic inhibitor G0S2 enhances intravascular triglyceride clearance and abolishes diet-induced hypertriglyceridemia.The Journal of clinical investigation · 2025Article
- Lipolysis-derived fatty acids are needed for homeostatic control of sterol element-binding protein-1c driven hepatic lipogenesis.Communications biology · 2025Article
- Non-canonical lysosomal lipolysis drives mobilization of adipose tissue energy stores with fasting.Nature communications · 2025Article
- The BET inhibitor JQ1 targets fat metabolism and counteracts obesity.Journal of advanced research · 2025Article
- Overnutrition causes insulin resistance and metabolic disorder through increased sympathetic nervous system activity.Cell metabolism · 2025Article
- Transcriptional regulation of adipocyte lipolysis by IRF2BP2.Science advances · 2025Article
- Hepatocyte-specific loss of melanocortin 1 receptor disturbs fatty acid metabolism and promotes adipocyte hypertrophy.International journal of obesity (2005) · 2024Article
59 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 2 institutions in 2 countries.
Gabriele SchoiswohlDivision of Endocrinology and Metabolism (G.S., M.S.-R., R.C.W., B.A.S., M.K.B., M.T.S., L.C., C.F.Y., R.M.O., E.E.K.), Department of Medicine, and Department of Cell Biology (D.B.S.), University of Pittsburgh, Pittsburgh, Pennsylvania 15261; Department of Obstetrics, Gynecology, and Reproductive Sciences (M.N.M.), Magee-Womens Hospital, University of Pittsburgh, Pittsburgh, Pennsylvania 15213; and Department of Biochemistry and Molecular Biology (T.P.), Dalhousie Medicine New Brunswick, Dalhousie University, St John, Canada NB E2L 4L5.
Maja Stefanovic-RacicDivision of Endocrinology and Metabolism (G.S., M.S.-R., R.C.W., B.A.S., M.K.B., M.T.S., L.C., C.F.Y., R.M.O., E.E.K.), Department of Medicine, and Department of Cell Biology (D.B.S.), University of Pittsburgh, Pittsburgh, Pennsylvania 15261; Department of Obstetrics, Gynecology, and Reproductive Sciences (M.N.M.), Magee-Womens Hospital, University of Pittsburgh, Pittsburgh, Pennsylvania 15213; and Department of Biochemistry and Molecular Biology (T.P.), Dalhousie Medicine New Brunswick, Dalhousie University, St John, Canada NB E2L 4L5.
Marie N MenkeDivision of Endocrinology and Metabolism (G.S., M.S.-R., R.C.W., B.A.S., M.K.B., M.T.S., L.C., C.F.Y., R.M.O., E.E.K.), Department of Medicine, and Department of Cell Biology (D.B.S.), University of Pittsburgh, Pittsburgh, Pennsylvania 15261; Department of Obstetrics, Gynecology, and Reproductive Sciences (M.N.M.), Magee-Womens Hospital, University of Pittsburgh, Pittsburgh, Pennsylvania 15213; and Department of Biochemistry and Molecular Biology (T.P.), Dalhousie Medicine New Brunswick, Dalhousie University, St John, Canada NB E2L 4L5.
Rachel C WillsDivision of Endocrinology and Metabolism (G.S., M.S.-R., R.C.W., B.A.S., M.K.B., M.T.S., L.C., C.F.Y., R.M.O., E.E.K.), Department of Medicine, and Department of Cell Biology (D.B.S.), University of Pittsburgh, Pittsburgh, Pennsylvania 15261; Department of Obstetrics, Gynecology, and Reproductive Sciences (M.N.M.), Magee-Womens Hospital, University of Pittsburgh, Pittsburgh, Pennsylvania 15213; and Department of Biochemistry and Molecular Biology (T.P.), Dalhousie Medicine New Brunswick, Dalhousie University, St John, Canada NB E2L 4L5.
Beth A SurlowDivision of Endocrinology and Metabolism (G.S., M.S.-R., R.C.W., B.A.S., M.K.B., M.T.S., L.C., C.F.Y., R.M.O., E.E.K.), Department of Medicine, and Department of Cell Biology (D.B.S.), University of Pittsburgh, Pittsburgh, Pennsylvania 15261; Department of Obstetrics, Gynecology, and Reproductive Sciences (M.N.M.), Magee-Womens Hospital, University of Pittsburgh, Pittsburgh, Pennsylvania 15213; and Department of Biochemistry and Molecular Biology (T.P.), Dalhousie Medicine New Brunswick, Dalhousie University, St John, Canada NB E2L 4L5.
Mahesh K BasantaniDivision of Endocrinology and Metabolism (G.S., M.S.-R., R.C.W., B.A.S., M.K.B., M.T.S., L.C., C.F.Y., R.M.O., E.E.K.), Department of Medicine, and Department of Cell Biology (D.B.S.), University of Pittsburgh, Pittsburgh, Pennsylvania 15261; Department of Obstetrics, Gynecology, and Reproductive Sciences (M.N.M.), Magee-Womens Hospital, University of Pittsburgh, Pittsburgh, Pennsylvania 15213; and Department of Biochemistry and Molecular Biology (T.P.), Dalhousie Medicine New Brunswick, Dalhousie University, St John, Canada NB E2L 4L5.
Mitch T SitnickDivision of Endocrinology and Metabolism (G.S., M.S.-R., R.C.W., B.A.S., M.K.B., M.T.S., L.C., C.F.Y., R.M.O., E.E.K.), Department of Medicine, and Department of Cell Biology (D.B.S.), University of Pittsburgh, Pittsburgh, Pennsylvania 15261; Department of Obstetrics, Gynecology, and Reproductive Sciences (M.N.M.), Magee-Womens Hospital, University of Pittsburgh, Pittsburgh, Pennsylvania 15213; and Department of Biochemistry and Molecular Biology (T.P.), Dalhousie Medicine New Brunswick, Dalhousie University, St John, Canada NB E2L 4L5.
Lingzhi CaiDivision of Endocrinology and Metabolism (G.S., M.S.-R., R.C.W., B.A.S., M.K.B., M.T.S., L.C., C.F.Y., R.M.O., E.E.K.), Department of Medicine, and Department of Cell Biology (D.B.S.), University of Pittsburgh, Pittsburgh, Pennsylvania 15261; Department of Obstetrics, Gynecology, and Reproductive Sciences (M.N.M.), Magee-Womens Hospital, University of Pittsburgh, Pittsburgh, Pennsylvania 15213; and Department of Biochemistry and Molecular Biology (T.P.), Dalhousie Medicine New Brunswick, Dalhousie University, St John, Canada NB E2L 4L5.
Cynthia F YazbeckDivision of Endocrinology and Metabolism (G.S., M.S.-R., R.C.W., B.A.S., M.K.B., M.T.S., L.C., C.F.Y., R.M.O., E.E.K.), Department of Medicine, and Department of Cell Biology (D.B.S.), University of Pittsburgh, Pittsburgh, Pennsylvania 15261; Department of Obstetrics, Gynecology, and Reproductive Sciences (M.N.M.), Magee-Womens Hospital, University of Pittsburgh, Pittsburgh, Pennsylvania 15213; and Department of Biochemistry and Molecular Biology (T.P.), Dalhousie Medicine New Brunswick, Dalhousie University, St John, Canada NB E2L 4L5.
Donna B StolzDivision of Endocrinology and Metabolism (G.S., M.S.-R., R.C.W., B.A.S., M.K.B., M.T.S., L.C., C.F.Y., R.M.O., E.E.K.), Department of Medicine, and Department of Cell Biology (D.B.S.), University of Pittsburgh, Pittsburgh, Pennsylvania 15261; Department of Obstetrics, Gynecology, and Reproductive Sciences (M.N.M.), Magee-Womens Hospital, University of Pittsburgh, Pittsburgh, Pennsylvania 15213; and Department of Biochemistry and Molecular Biology (T.P.), Dalhousie Medicine New Brunswick, Dalhousie University, St John, Canada NB E2L 4L5.
Thomas PulinilkunnilDivision of Endocrinology and Metabolism (G.S., M.S.-R., R.C.W., B.A.S., M.K.B., M.T.S., L.C., C.F.Y., R.M.O., E.E.K.), Department of Medicine, and Department of Cell Biology (D.B.S.), University of Pittsburgh, Pittsburgh, Pennsylvania 15261; Department of Obstetrics, Gynecology, and Reproductive Sciences (M.N.M.), Magee-Womens Hospital, University of Pittsburgh, Pittsburgh, Pennsylvania 15213; and Department of Biochemistry and Molecular Biology (T.P.), Dalhousie Medicine New Brunswick, Dalhousie University, St John, Canada NB E2L 4L5.
Robert M O'DohertyDivision of Endocrinology and Metabolism (G.S., M.S.-R., R.C.W., B.A.S., M.K.B., M.T.S., L.C., C.F.Y., R.M.O., E.E.K.), Department of Medicine, and Department of Cell Biology (D.B.S.), University of Pittsburgh, Pittsburgh, Pennsylvania 15261; Department of Obstetrics, Gynecology, and Reproductive Sciences (M.N.M.), Magee-Womens Hospital, University of Pittsburgh, Pittsburgh, Pennsylvania 15213; and Department of Biochemistry and Molecular Biology (T.P.), Dalhousie Medicine New Brunswick, Dalhousie University, St John, Canada NB E2L 4L5.
Erin E KershawDivision of Endocrinology and Metabolism (G.S., M.S.-R., R.C.W., B.A.S., M.K.B., M.T.S., L.C., C.F.Y., R.M.O., E.E.K.), Department of Medicine, and Department of Cell Biology (D.B.S.), University of Pittsburgh, Pittsburgh, Pennsylvania 15261; Department of Obstetrics, Gynecology, and Reproductive Sciences (M.N.M.), Magee-Womens Hospital, University of Pittsburgh, Pittsburgh, Pennsylvania 15213; and Department of Biochemistry and Molecular Biology (T.P.), Dalhousie Medicine New Brunswick, Dalhousie University, St John, Canada NB E2L 4L5.
University of Pittsburgh · USDalhousie University · CA
Funding
T32 Research Training in Diabetes and EndocrinologyT32DK007052 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROBERT M O'DOHERTY · 1986 to 2026
$6.3MMagee-Womens Basic and Translational Reproductive Health Training ProgramK12HD063087 · NICHD · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI EDWARDS, ROBERT PAGE · 2009 to 2019
$3.7MLeptin Action and MacrophagesR01DK072162 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI O'DOHERTY, ROBERT M · 2006 to 2014
$2.7MAdipose Triglyceride Lipase (ATGL) in Lipotoxicity and The Metabolic SyndromeR01DK090166 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KERSHAW, ERIN E. · 2011 to 2015
$1.7MAustrian Science Fund FWF J 3221Howard Hughes Medical InstituteNICHD NIH HHS K12 HD063087NICHD NIH HHS K12HD063087NIDDK NIH HHS R01 DK072162NIDDK NIH HHS R01DK072162NIDDK NIH HHS R01 DK090166NIDDK NIH HHS R01DK090166NIDDK NIH HHS T32DK007042NIDDK NIH HHS T32 DK007052
Abstract
Emerging evidence suggests that impaired regulation of adipocyte lipolysis contributes to the proinflammatory immune cell infiltration of metabolic tissues in obesity, a process that is proposed to contribute to the development and exacerbation of insulin resistance. To test this hypothesis in vivo, we generated mice with adipocyte-specific deletion of adipose triglyceride lipase (ATGL), the rate-limiting enzyme catalyzing triacylglycerol hydrolysis. In contrast to previous models, adiponectin-driven Cre expression was used for targeted ATGL deletion. The resulting adipocyte-specific ATGL knockout (AAKO) mice were then characterized for metabolic and immune phenotypes. Lean and diet-induced obese AAKO mice had reduced adipocyte lipolysis, serum lipids, systemic lipid oxidation, and expression of peroxisome proliferator-activated receptor alpha target genes in adipose tissue (AT) and liver. These changes did not increase overall body weight or fat mass in AAKO mice by 24 weeks of age, in part due to reduced expression of genes involved in lipid uptake, synthesis, and adipogenesis. Systemic glucose and insulin tolerance were improved in AAKO mice, primarily due to enhanced hepatic insulin signaling, which was accompanied by marked reduction in diet-induced hepatic steatosis as well as hepatic immune cell infiltration and activation. In contrast, although adipocyte ATGL deletion reduced AT immune cell infiltration in response to an acute lipolytic stimulus, it was not sufficient to ameliorate, and may even exacerbate, chronic inflammatory changes that occur in AT in response to diet-induced obesity.
Indexed as
AcyltransferasesAdipocytesAdipose TissueAnimalsAntigens, DifferentiationCD11c AntigenDendritic CellsDiet, High-FatGene ExpressionImmunoblottingInflammationInsulin ResistanceLipaseLipid MetabolismLipidsLipolysisAcyltransferasesAntigens, DifferentiationCD11c AntigenLipaseLipidsmonocyte-macrophage differentiation antigenPNPLA2 protein, mouse
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.