ArticleEnvironmental science & technology2015
Development of an Immunoassay for the Detection of the Phenylpyrazole Insecticide Fipronil.
Article in Environmental science & technology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 68 citations in OpenAlex.
- Immunoassays and Emerging Analytical Techniques of Fipronil and its Metabolites for Food Safety: A Review.Journal of agricultural and food chemistry · 2024Review
- Metabolism of an insecticide fipronil by soil fungus Cunninghamella elegans ATCC36112.Archives of microbiology · 2023Article
- Development of immunoassay based on a specific antibody for sensitive detection of nicosulfuron in environment.The Science of the total environment · 2023Article
- Identification and Application of Two Promising Peptide Ligands for the Immunodetection of Imidacloprid Residue.Foods (Basel, Switzerland) · 2022Article
- A Sensitive Monoclonal-Antibody-Based ELISA for Forchlorfenuron Residue Analysis in Food Samples.Biosensors · 2022Article
- Rapid, label-free, and sensitive point-of-care testing of anti-SARS-CoV-2 IgM/IgG using all-fiber Fresnel reflection microfluidic biosensor.Mikrochimica acta · 2021Article
- Reusable optofluidic point-of-care testing platform with lyophilized specific antibody for fluorescence detection of cholylglycine in serum.Mikrochimica acta · 2020Article
- Monitoring of the Organophosphate Pesticide Chlorpyrifos in Vegetable Samples from Local Markets in Northern Thailand by Developed Immunoassay.International journal of environmental research and public health · 2020Article
- Fluorometric determination of fipronil by integrating the advantages of molecularly imprinted silica and carbon quantum dots.Mikrochimica acta · 2019Article
- The Importance of Community Engagement and Research Translation within the NIEHS Superfund Research Program.International journal of environmental research and public health · 2019Article
- Hapten Synthesis, Antibody Development, and a Highly Sensitive Indirect Competitive Chemiluminescent Enzyme Immunoassay for Detection of Dicamba.Journal of agricultural and food chemistry · 2019Article
- Surface-Enhanced Raman Scattering Detection of Fipronil Pesticide Adsorbed on Silver Nanoparticles.Sensors (Basel, Switzerland) · 2019Article
- Development of a one-step immunoassay for triazophos using camel single-domain antibody-alkaline phosphatase fusion protein.Analytical and bioanalytical chemistry · 2019Article
- Quantitative Detection of Fipronil and Fipronil-Sulfone in Sera of Black-Tailed Prairie Dogs and Rats after Oral Exposure to Fipronil by Camel Single-Domain Antibody-Based Immunoassays.Analytical chemistry · 2019Article
- Colorimetric and chemiluminescent dual-readout immunochromatographic assay for detection of pesticide residues utilizing g-CBiosensors & bioelectronics · 2018Article
- In Vitro Selection of a Single-Stranded DNA Molecular Recognition Element against the Pesticide Fipronil and Sensitive Detection in River Water.International journal of molecular sciences · 2017Article
- Development of an Indirect Competitive Enzyme-Linked Immunosorbent Assay for Glycocholic Acid Based on Chicken Single-Chain Variable Fragment Antibodies.Analytical chemistry · 2017Article
- Development of Tetramethylenedisulfotetramine (TETS) Hapten Library: Synthesis, Electrophysiological Studies, and Immune Response in Rabbits.Chemistry (Weinheim an der Bergstrasse, Germany) · 2017Article
- Hydroxy-fipronil is a new urinary biomarker of exposure to fipronil.Environment international · 2017Article
- Sensitive Immunoassay for Detection and Quantification of the Neurotoxin, Tetramethylenedisulfotetramine.Analytical chemistry · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Phenylpyrazole insecticides such as fipronil have been used as replacements for organophosphates. The wide application of fipronil raises concern about environmental contamination and risk for fish, birds, and other nontargeted beings as well as human health. A sensitive, competitive indirect heterologous enzyme-linked immunosorbent assay (ELISA) was developed. Antibodies with different specificities to fipronil and its metabolites were produced. Two ELISAs having IC50 values of 0.58 ± 0.06 and 2.6 ± 0.4 ng/mL were developed. Design of different haptens and coating antigens resulted in two assays with distinct cross-reactivity patterns for structurally related compounds: 96, 38, and 101% versus 39, 1.4, and 25% for fipronil-sulfide, fipronil-detrifluoromethylsulfonyl, and fipronil-desulfinyl, respectively. Performance of the immunoassays was demonstrated by a recovery study from spiked water and human serum and urine matrices, giving recovery values in the range of 85-111% for different concentrations. The assays demonstrated good correlation in fipronil recovery with conventional LC-MS/MS analysis. The generic assay 2265 has the sensitivity to measure fipronil and its analogs in serum at levels relevant for exposure monitoring. The assays were used to analyze human urine samples obtained from exposure studies and serum samples from rats treated with a fipronil-containing diet.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.