ArticleCritical care medicine2015
Critical Care for Multiple Organ Failure Secondary to Ebola Virus Disease in the United States.
Article in Critical care medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Anti-Ebola therapy for patients with Ebola virus disease: a systematic review.BMC infectious diseases · 2019Pooled it
- Bacterial Infection in Ebola Virus Disease, Marburg Virus Disease, Crimean-Congo Hemorrhagic Fever, and Lassa Fever.Open forum infectious diseases · 2026Review
- A premature newborn born to an adolescent girl with acute Ebola virus disease and malaria survives in a resource-limited setting in an Ebola treatment unit in DR Congo: "A case report".Clinical case reports · 2023Article
- Mechanisms of phosphatidylserine influence on viral production: A computational model of Ebola virus matrix protein assembly.The Journal of biological chemistry · 2022Article
- Ebola virus disease.Nature reviews. Disease primers · 2020Review
- Caseload and Case Fatality of Lassa Fever in Nigeria, 2001-2018: A Specialist Center's Experience and Its Implications.Frontiers in public health · 2019Article
- Post-exposure treatments for Ebola and Marburg virus infections.Nature reviews. Drug discovery · 2018Review
- Ebola virus disease: an update on post-exposure prophylaxis.The Lancet. Infectious diseases · 2018Review
- QTc interval prolongation during favipiravir therapy in an Ebolavirus-infected patient.PLoS neglected tropical diseases · 2017Article
- High-Containment Pathogen Preparation in the Intensive Care Unit.Infectious disease clinics of North America · 2017Review
- Insights from clinical research completed during the west Africa Ebola virus disease epidemic.The Lancet. Infectious diseases · 2017Review
- Ebola virus disease and pregnancy: A review of the current knowledge of Ebola virus pathogenesis, maternal, and neonatal outcomes.Birth defects research · 2017Review
- Safety Precautions and Operating Procedures in an (A)BSL-4 Laboratory: 4. Medical Imaging Procedures.Journal of visualized experiments : JoVE · 2016Article
- Kinetic Analysis of Biomarkers in a Cohort of US Patients With Ebola Virus Disease.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Article
- Ebola virus disease and critical illness.Critical care (London, England) · 2016Review
- Preparing for Serious Communicable Diseases in the United States: What the Ebola Virus Epidemic Has Taught Us.Microbiology spectrum · 2016Article
- Clinical Management of Ebola Virus Disease in the United States and Europe.The New England journal of medicine · 2016Article
- Caring for Critically Ill Ebola Virus Disease Patients With One Hand Tied Behind Your Back.Critical care medicine · 2015Article
- Clinical Management of Patients with Ebola Virus Disease in High-Resource Settings.Current topics in microbiology and immunologyReview
- Ebola Virus Disease in Humans: Pathophysiology and Immunity.Current topics in microbiology and immunologyReview
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Authors and funding
12 authors at 7 institutions in 2 countries.
Funding
Abstract
objectiveThis report describes three patients with Ebola virus disease who were treated in the United States and developed for severe critical illness and multiple organ failure secondary to Ebola virus infection. The patients received mechanical ventilation, renal replacement therapy, invasive monitoring, vasopressor support, and investigational therapies for Ebola virus disease. DATA SOURCES: Patient medical records from three tertiary care centers (Emory University Hospital, University of Nebraska Medical Center, and Texas Health Presbyterian Dallas Hospital). STUDY SELECTION: Not applicable. DATA EXTRACTION: Not applicable. DATA SYNTHESIS: Not applicable.
conclusionIn the severe form, patients with Ebola virus disease may require life-sustaining therapy, including mechanical ventilation and renal replacement therapy. In conjunction with other reported cases, this series suggests that respiratory and renal failure may occur in severe Ebola virus disease, especially in patients burdened with high viral loads. Ebola virus disease complicated by multiple organ failure can be survivable with the application of advanced life support measures. This collective, multicenter experience is presented with the hope that it may inform future treatment of patients with Ebola virus disease requiring critical care treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.