Trial reportPloS one2015
Comparative Phytochemical Analysis of Essential Oils from Different Biological Parts of Artemisia herba alba and Their Cytotoxic Effect on Cancer Cells.
Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- A Review of Cytotoxic Plants of the Indian Subcontinent and a Broad-Spectrum Analysis of Their Bioactive Compounds.Molecules (Basel, Switzerland) · 2020Pooled it
- HarnessingInternational journal of molecular sciences · 2025Review
- Evaluation of antioxidant, anticholinesterase and antiproliferative potential of Artemisia herba-alba by artificial intelligence-assisted extraction optimization.Scientific reports · 2025Article
- GC/MS Analysis, Cytotoxicity, and Antimicrobial Properties of Six Moroccan Essential Oils Traditionally Used for COVID-19 Prevention.Molecules (Basel, Switzerland) · 2025Article
- Chemical profiling and biological assessment of essential oil from Artemisia herba-alba.Scientific reports · 2025Article
- Exploring the Anticancer Effect ofFood science & nutrition · 2025Article
- Procedures to evaluate potential of plants as natural food preservatives: Phytochemical characterization, novel extraction technology, and safety evaluation-A comprehensive review.Food science & nutrition · 2024Review
- Antifungal Activities of Essential Oils in Vapor Phase againstFoods (Basel, Switzerland) · 2022Article
- Article
- Moroccan Medicinal Plants Used to Treat Cancer: Ethnomedicinal Study and Insights into Pharmacological Evidence.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Effect of Essential Oils on Growth Inhibition, Biofilm Formation and Membrane Integrity ofAntibiotics (Basel, Switzerland) · 2021Article
- Traditional medicinal knowledge of plants used for cancer treatment by communities of mountainous areas of Fez-Meknes-Morocco.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2021Article
- Phenolic Composition, Antioxidant Capacity and Antibacterial Activity of White Wormwood (Plants (Basel, Switzerland) · 2021Article
- Terpenes from essential oils and hydrolate ofOncotarget · 2018Article
- Studies on the Dual Cytotoxicity and Antioxidant Properties ofAdvances in pharmacological sciences · 2018Article
- A Systematic Review of Anti-malarial Properties, Immunosuppressive Properties, Anti-inflammatory Properties, and Anti-cancer Properties of Artemisia Annua.Electronic physician · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCarrying out the chemical composition and antiproliferative effects against cancer cells from different biological parts of Artemisia herba alba.
methodsEssential oils were studied by gas chromatography coupled to mass spectrometry (GC-MS) and their antitumoral activity was tested against P815 mastocytoma and BSR kidney carcinoma cell lines; also, in order to evaluate the effect on normal human cells, oils were tested against peripheral blood mononuclear cells PBMCs.
resultsEssential oils from leaves and aerial parts (mixture of capitulum and leaves) were mainly composed by oxygenated sesquiterpenes 39.89% and 46.15% respectively; capitulum oil contained essentially monoterpenes (22.86%) and monocyclic monoterpenes (21.48%); esters constituted the major fraction (62.8%) of stem oil. Essential oils of different biological parts studied demonstrated a differential antiproliferative activity against P815 and BSR cancer cells; P815 cells are the most sensitive to the cytotoxic effect. Leaves and capitulum essential oils are more active than aerial parts. Interestingly, no cytotoxic effect of these essential oils was observed on peripheral blood mononuclear cells.
conclusionOur results showed that the chemical composition variability of essential oils depends on the nature of botanical parts of Artemisia herba alba. Furthermore, we have demonstrated that the differential cytotoxic effect depends not only on the essential oils concentration, but also on the target cells and the botanical parts of essential oils used.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.