Evidence map›Paper›PMID 26195980›Full record

ArticleDementia and geriatric cognitive disorders extra

Relationship between Dementia Severity and Behavioral and Psychological Symptoms of Dementia in Dementia with Lewy Bodies and Alzheimer's Disease Patients.

Mamoru Hashimoto, Yusuke Yatabe, Tomohisa Ishikawa, Ryuji Fukuhara, Keiichiro Kaneda, Kazuki Honda, Seiji Yuki, Yusuke Ogawa, Toru Imamura, Hiroaki Kazui and 5 more

Open access · goldAbstract read
In one paragraph

Article in Dementia and geriatric cognitive disorders extra. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 3 pooled it
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 61 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Trial
  5. Article
  6. Co-pathology in Alzheimer's disease and Lewy body disease and its association with neuropsychiatric symptoms.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  7. Article
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  10. Secular trends in the prevalence of dementia based on a community-based complete enumeration in Japan: the Nakayama Study.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2022
    Article
  11. Article
  12. Article
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  14. Heterogeneity in Alzheimer's Disease Diagnosis and Progression Rates: Implications for Therapeutic Trials.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 1 country.

Mamoru HashimotoDepartment of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Tokyo, Japan.
Yusuke YatabeDepartment of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Tokyo, Japan.
Tomohisa IshikawaDepartment of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Tokyo, Japan.
Ryuji FukuharaDepartment of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Tokyo, Japan ; Department of Neuropsychiatry, Ehime University Graduate School of Medicine, Toon, Tokyo, Japan.
Keiichiro KanedaDepartment of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Tokyo, Japan.
Kazuki HondaDepartment of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Tokyo, Japan.
Seiji YukiDepartment of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Tokyo, Japan.
Yusuke OgawaDepartment of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Tokyo, Japan.
Toru ImamuraDivision of Speech, Hearing and Cognitive Sciences, Graduate School of Health and Welfare, Niigata University of Health and Welfare, Niigata, Tokyo, Japan.
Hiroaki KazuiPsychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University, Suita, Tokyo, Japan.
Naoto KamimuraDepartment of Neuropsychiatry, Kochi Medical School, Nankoku, Tokyo, Japan.
Syunichiro ShinagawaDepartment of Psychiatry, Jikei University School of Medicine, Tokyo, Japan.
Katsuyoshi MizukamiGraduate School of Comprehensive Human Sciences, University of Tsukuba, Tokyo, Japan.
Etsuro MoriDepartment of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan.
Manabu IkedaDepartment of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Tokyo, Japan.
Kumamoto University · JPJikei University School of Medicine · JPKochi Medical School Hospital · JPNiigata University of Health and Welfare · JPOsaka University · JPTohoku University · JPUniversity of Tsukuba · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsBehavioral and psychological symptoms of dementia (BPSD) are common in the clinical manifestation of dementia. Although most patients with dementia exhibit some BPSD during the course of the illness, the association of BPSD with the stage of dementia remains unclear. It was the aim of this study to evaluate the impact of severity of dementia on the expression of BPSD in patients with dementia with Lewy bodies (DLB) and Alzheimer's disease (AD).

methodsNinety-seven patients with DLB and 393 patients with AD were recruited from 8 dementia clinics across Japan. BPSD were assessed by the Neuropsychiatric Inventory (NPI). A relationship between BPSD and dementia stage classified by the Clinical Dementia Rating (CDR) in each type of dementia was assessed.

resultsNo significant difference was seen in NPI total score across CDR staging in the DLB group. On the other hand, the NPI total score significantly increased with dementia stage in the AD group.

conclusionThe relationship of dementia stage with the expression of BPSD was different according to the type of dementia. BPSD and dementia stage were correlated in AD subjects, in whom psychiatric symptoms increase as the disease progresses, but not in DLB subjects.

Indexed as

Alzheimer's diseaseDementia with Lewy bodiesNeuropsychiatric symptomsSeverity of dementia

Identifiers

PMID26195980
PMCPMC4483492
OpenAlexW1495729168

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.