Evidence map›Paper›PMID 26195922›Full record

ArticleGerman medical science : GMS e-journal2015

Risks, risk assessment and risk competence in toxicology.

Ralf Stahlmann, Aniko Horvath

Abstract read
In one paragraph

Article in German medical science : GMS e-journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ralf StahlmannUniversity Hospital Charité Berlin, Institute for Clinical Pharmacology and Toxicology, Berlin, Germany.
Aniko HorvathUniversity Hospital Charité Berlin, Institute for Clinical Pharmacology and Toxicology, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding the toxic effects of xenobiotics requires sound knowledge of physiology and biochemistry. The often described lack of understanding pharmacology/toxicology is therefore primarily caused by the general absence of the necessary fundamental knowledge. Since toxic effects depend on exposure (or dosage) assessing the risks arising from toxic substances also requires quantitative reasoning. Typically public discussions nearly always neglect quantitative aspects and laypersons tend to disregard dose-effect-relationships. One of the main reasons for such disregard is the fact that exposures often occur at extremely low concentrations that can only be perceived intellectually but not by the human senses. However, thresholds in the low exposure range are often scientifically disputed. At the same time, ignorance towards known dangers is wide-spread. Thus, enhancing the risk competence of laypersons will have to be initially restricted to increasing the awareness of existing problems.

Indexed as

Health Knowledge, Attitudes, PracticeRisk ManagementToxicologyAluminumAnimalsCarbon MonoxideDose-Response Relationship, DrugHumansNo-Observed-Adverse-Effect LevelPyrrolizidine AlkaloidsRisk AssessmentRisk FactorsAluminumCarbon MonoxidePyrrolizidine Alkaloidsdose-effect-relationshipsfundamental knowledgeknown riskslow concentrationsproblem awarenesstoxicology

Identifiers

PMID26195922
PMCPMC4507061

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.