ArticleJournal of immunology (Baltimore, Md. : 1950)2015
Restoration of CD4+ Responses to Copathogens in HIV-Infected Individuals on Antiretroviral Therapy Is Dependent on T Cell Memory Phenotype.
Article in Journal of immunology (Baltimore, Md. : 1950), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Valganciclovir modulates the tumor necrosis factor axis molecules expression and CD4+ T-cell subsets in disseminated Kaposi Sarcoma patients.Clinical and experimental immunology · 2024Trial
- CCR5-edited CD4+ T cells augment HIV-specific immunity to enable post-rebound control of HIV replication.The Journal of clinical investigation · 2021Trial
- Antiretroviral Treatment-Induced Decrease in Immune Activation Contributes to Reduced Susceptibility to Tuberculosis in HIV-1/Mtb Co-infected Persons.Frontiers in immunology · 2021Trial
- A hospital-based observational study on HIV-TB co-infection.Access microbiology · 2025Article
- T Cell Responses during Human Immunodeficiency Virus/Vaccines · 2024Review
- High-parameter phenotypic characterization reveals a subset of human Th17 cells that preferentially produce IL17 againstbioRxiv : the preprint server for biology · 2024Article
- High-parameter phenotypic characterization reveals a subset of human Th17 cells that preferentially produce IL-17 againstFrontiers in immunology · 2024Article
- Homologous Ad26.COV2.S vaccination results in reduced boosting of humoral responses in hybrid immunity, but elicits antibodies of similar magnitude regardless of prior infection.PLoS pathogens · 2023Article
- Th22 Cells Are a Major Contributor to the Mycobacterial CD4Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Article
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- Immune Phenotype and Functionality ofPathogens (Basel, Switzerland) · 2020Article
- The forces driving clonal expansion of the HIV-1 latent reservoir.Virology journal · 2020Review
- Tuberculosis Antigen-Specific T-Cell Responses During the First 6 Months of Antiretroviral Treatment.The Journal of infectious diseases · 2020Article
- Differential Pathogen-Specific Immune Reconstitution in Antiretroviral Therapy-Treated Human Immunodeficiency Virus-Infected Children.The Journal of infectious diseases · 2019Article
- Residual T cell activation and skewed CD8+ T cell memory differentiation despite antiretroviral therapy-induced HIV suppression.Clinical immunology (Orlando, Fla.) · 2018Article
- Article
- HIV-1 Infection Is Associated with Depletion and Functional Impairment ofJournal of immunology (Baltimore, Md. : 1950) · 2017Article
- Human cytomegalovirus (CMV) in Africa: a neglected but important pathogen.Journal of virus eradication · 2016Article
- The immunopathogenesis of cryptococcal immune reconstitution inflammatory syndrome: understanding a conundrum.Current opinion in infectious diseases · 2016Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Antiretroviral therapy (ART) induces rapid suppression of viral replication and a progressive replenishment of CD4(+) T cells in HIV-infected individuals. However, the effect of ART on restoring pre-existing memory CD4(+) T cells specific for common copathogens is still unclear. To better understand the dynamics of Ag-specific CD4(+) T cells during ART, we assessed the frequency, functional capacity, and memory profile of CD4(+) T cells specific for Mycobacterium tuberculosis and CMV in 15 HIV-infected individuals before and 1 y after ART initiation. After ART initiation, the frequency of M. tuberculosis-specific CD4(+) T cells showed little change, whereas CMV-specific CD4(+) T cells were significantly lower (p = 0.003). There was no difference in the polyfunctional or memory profile of Ag-specific CD4(+) T cells before and after ART. The replenishment of Ag-specific CD4(+) T cells correlated with the memory differentiation profile of these cells prior to ART. Pathogen-specific CD4(+) T cells exhibiting a late differentiated profile (CD45RO(+)CD27(-)) had a lower capacity to replenish (p = 0.019; r = -0.5) compared with cells with an early differentiated profile (CD45RO(+)CD27(+); p = 0.04; r = 0.45). In conclusion, restoration of copathogen-specific memory CD4(+) T cells during treated HIV infection is related to their memory phenotype, in which early differentiated cells (such as most M. tuberculosis-specific cells) have a higher replenishment capacity compared with late differentiated cells (such as most CMV-specific cells). These data identify an important, hitherto unrecognized, factor that may limit restoration of copathogen immunity in HIV-infected individuals on ART.
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Registered trials
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