Evidence map›Paper›PMID 26195752›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2015

Reduced transmission of human schistosomiasis after restoration of a native river prawn that preys on the snail intermediate host.

Susanne H Sokolow, Elizabeth Huttinger, Nicolas Jouanard, Michael H Hsieh, Kevin D Lafferty, Armand M Kuris, Gilles Riveau, Simon Senghor, Cheikh Thiam, Alassane N'Diaye and 2 more

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 86 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 3 pooled it
13.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 3 syntheses or guidelines pooled it, 225 citations in OpenAlex.

  1. Pooled it
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  13. Article
  14. Freshwater snail-borne parasitic diseases in Africa.Tropical medicine and health · 2024
    Review
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  17. Article
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  19. Article
  20. Development of prediction models to identify hotspots of schistosomiasis in endemic regions to guide mass drug administration.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Susanne H SokolowDepartment of Biology, Hopkins Marine Station, Stanford University, Pacific Grove, CA 93950; Department of Ecology, Evolution, and Marine Biology and Marine Science Institute, University of California, Santa Barbara, CA 93106; shsokolow@gmail.com.
Elizabeth Huttinger20|20 Initiative, Pasadena, CA 91105;
Nicolas Jouanard20|20 Initiative, Pasadena, CA 91105;
Michael H HsiehDepartment of Urology, School of Medicine, Stanford University, Stanford, CA 94304; Department of Research and Development, Biomedical Research Institute, Rockville, Maryland 20852; Division of Urology, Children's National Health System, Washington, DC 20010; Department of Urology, The George Washington University, Washington, DC 20037;
Kevin D LaffertyUS Geological Survey, Western Ecological Research Center, Marine Science Institute, University of California, Santa Barbara, CA 93106;
Armand M KurisDepartment of Ecology, Evolution, and Marine Biology and Marine Science Institute, University of California, Santa Barbara, CA 93106;
Gilles RiveauCentre d'Infection et d'Immunité de Lille, Institut Pasteur de Lille, 59019 Lille, France; Espoir pour la Santé, Laboratoire de Recherches Biomédicales, BP 226 Saint-Louis, Senegal.
Simon SenghorEspoir pour la Santé, Laboratoire de Recherches Biomédicales, BP 226 Saint-Louis, Senegal.
Cheikh Thiam20|20 Initiative, Pasadena, CA 91105;
Alassane N'Diaye20|20 Initiative, Pasadena, CA 91105;
Djibril Sarr Faye20|20 Initiative, Pasadena, CA 91105;
Giulio A De LeoDepartment of Biology, Hopkins Marine Station, Stanford University, Pacific Grove, CA 93950;
University of California, Santa Barbara · USCenter for Infection and Immunity of Lille · FREspoir pour la Sante · SNGeorge Washington University · USStanford University · US

Funding

Estrogenic Modulation of Genitourinary Epithelial-Probiotic Cross-TalkK08DK087895 · NIDDK · STANFORD UNIVERSITY · PI HSIEH, MICHAEL HARRISON · 2010 to 2014
$902k
Emergence and biological control of schistosomiasisK08AI082284 · NIAID · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI SOKOLOW, SUSANNE H · 2009 to 2011
$338k
NIAID NIH HHS K08 AI082284NIAID NIH HHS K08AI082284NIDDK NIH HHS K08 DK087895NIDDK NIH HHS K08DK087895
6 · The paper itself

Abstract

Eliminating human parasitic disease often requires interrupting complex transmission pathways. Even when drugs to treat people are available, disease control can be difficult if the parasite can persist in nonhuman hosts. Here, we show that restoration of a natural predator of a parasite's intermediate hosts may enhance drug-based schistosomiasis control. Our study site was the Senegal River Basin, where villagers suffered a massive outbreak and persistent epidemic after the 1986 completion of the Diama Dam. The dam blocked the annual migration of native river prawns (Macrobrachium vollenhoveni) that are voracious predators of the snail intermediate hosts for schistosomiasis. We tested schistosomiasis control by reintroduced river prawns in a before-after-control-impact field experiment that tracked parasitism in snails and people at two matched villages after prawns were stocked at one village's river access point. The abundance of infected snails was 80% lower at that village, presumably because prawn predation reduced the abundance and average life span of latently infected snails. As expected from a reduction in infected snails, human schistosomiasis prevalence was 18 ± 5% lower and egg burden was 50 ± 8% lower at the prawn-stocking village compared with the control village. In a mathematical model of the system, stocking prawns, coupled with infrequent mass drug treatment, eliminates schistosomiasis from high-transmission sites. We conclude that restoring river prawns could be a novel contribution to controlling, or eliminating, schistosomiasis.

Indexed as

RiversAdolescentAdultAnimalsBiomphalariaChildChild, PreschoolFemaleHost-Parasite InteractionsHumansMaleMiddle AgedModels, BiologicalPalaemonidaePredatory BehaviorPrevalencecontroldiseaseecologyeliminationneglected tropical disease

Identifiers

PMID26195752
PMCPMC4534245
OpenAlexW1836347966

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.