ArticleProceedings of the National Academy of Sciences of the United States of America2015
Impermanence of bacterial clones.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 56 citations in OpenAlex.
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- Lineage-specific variation in frequency and hotspots of recombination in invasive Escherichia coli.BMC genomics · 2025Article
- Pooled Antibiotic Susceptibility Testing Performs Within CLSI Standards for Validation When Measured Against Broth Microdilution and Disk Diffusion Antibiotic Susceptibility Testing of Cultured Isolates.Antibiotics (Basel, Switzerland) · 2024Article
- Co-evolution and Gene Transfers Drive Speciation Patterns in Host-Associated Bacteria.Molecular biology and evolution · 2024Article
- Strain-specific gut microbial signatures in type 2 diabetes identified in a cross-cohort analysis of 8,117 metagenomes.Nature medicine · 2024Article
- Evidence ofMicrobial genomics · 2024Article
- Evolution of homologous recombination rates across bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Sporadic cloneFrontiers in cellular and infection microbiology · 2024Article
- Recombination as an enforcement mechanism of prosocial behavior in cooperating bacteria.iScience · 2023Article
- Genomic data of an environmentalData in brief · 2021Article
- Mash-based analyses of Escherichia coli genomes reveal 14 distinct phylogroups.Communications biology · 2021Article
- Whole genome phylogenies reflect the distributions of recombination rates for many bacterial species.eLife · 2021Article
- The Population Genetics, Virulence, and Public Health Concerns ofFrontiers in microbiology · 2021Article
- Recombination events are concentrated in the spike protein region of Betacoronaviruses.PLoS genetics · 2020Article
- Impact of homologous recombination on core genome phylogenies.BMC genomics · 2020Article
- Diversity within species: interpreting strains in microbiomes.Nature reviews. Microbiology · 2020Review
- CoreSimul: a forward-in-time simulator of genome evolution for prokaryotes modeling homologous recombination.BMC bioinformatics · 2020Article
- Bartonella gene transfer agent: Evolution, function, and proposed role in host adaptation.Cellular microbiology · 2019Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Bacteria reproduce asexually and pass on a single genome copied from the parent, a reproductive mode that assures the clonal descent of progeny; however, a truly clonal bacterial species is extremely rare. The signal of clonality can be interrupted by gene uptake and exchange, initiating homologous recombination that results in the unique sequence of one clone being incorporated into another. Because recombination occurs sporadically and on local scales, these events are often difficult to recognize, even when considering large samples of completely sequenced genomes. Moreover, several processes can produce the appearance of clonality in populations that undergo frequent recombination. The rates and consequences of recombination have been studied in Escherichia coli for over 40 y, and, during this time, there have been several shifting views of its clonal status, population structure, and rates of gene exchange. We reexamine the studies and retrace the evolution of the methods that have assessed the extent of DNA flux, largely focusing on its impact on the E. coli genome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.