Evidence map›Paper›PMID 26195709›Full record

ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2015

Improvements in US Breast Cancer Survival and Proportion Explained by Tumor Size and Estrogen-Receptor Status.

Ju-Hyun Park, William F Anderson, Mitchell H Gail

Abstract read
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In one paragraph

Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

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  6. Observational
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  9. Narrative Approaches to Cancer Education: Striking the Right Tone.Journal of cancer education : the official journal of the American Association for Cancer Education · 2022
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Ju-Hyun ParkJu-Hyun Park, Dongguk University, Seoul, South Korea; and William F. Anderson and Mitchell H. Gail, National Cancer Institute, Bethesda, MD.
William F AndersonJu-Hyun Park, Dongguk University, Seoul, South Korea; and William F. Anderson and Mitchell H. Gail, National Cancer Institute, Bethesda, MD.
Mitchell H GailJu-Hyun Park, Dongguk University, Seoul, South Korea; and William F. Anderson and Mitchell H. Gail, National Cancer Institute, Bethesda, MD. gailm@mail.nih.gov.

Funding

Methods for Epidemiology StudiesZIACP010181 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ALBERT, PAUL · 2009 to 2025
$34.8M
Intramural NIH HHS
6 · The paper itself

Abstract

purposeBreast cancer mortality began declining in many Western countries during the late 1980s. We estimated the proportion of improvements in stage- and age-specific breast cancer survival in the United States explained by tumor size or estrogen receptor (ER) status.

methodsWe estimated hazard ratios for breast cancer-specific death from time of invasive breast cancer diagnosis in the National Cancer Institute's Surveillance, Epidemiology, and End Results 9 Registries Database from 1973 to 2010, with and without stratification by tumor size and ER status.

resultsHazards from breast cancer-specific death declined from 1973 to 2010, not only in the first 5 years after diagnosis, but also thereafter. Stratification by tumor size explained less than 17% of the improvements comparing 2005 to 2010 versus 1973 to 1979, except for women age ≥ 70 years with local (49%) or regional (38%) disease. Tumor size usually accounted for more of the improvement in the first 5 years after diagnosis than later. Additional adjustment for ER status (positive, negative, or unknown) from 1990 to 2010 did not explain much more of the improvement, except for women age ≥ 70 years within 5 years after diagnosis.

conclusionMost stage-specific survival improvement in women younger than age 70 years old is unexplained by tumor size and ER status, suggesting a key role for treatment. In the first 5 years after diagnosis, tumor size contributed importantly for women ≥ 70 years old with local and regional stage, and stratification by tumor size and ER status explained even more of the survival improvement among women age ≥ 70 years.

Indexed as

AdultAgedBreast NeoplasmsFemaleHumansMiddle AgedReceptors, EstrogenSEER ProgramReceptors, Estrogen

Identifiers

PMID26195709
PMCPMC4554748

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.