ArticleInfection and immunity2015
Candida albicans Quorum Sensing Molecules Stimulate Mouse Macrophage Migration.
Article in Infection and immunity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- The role of serum albumin inApplied and environmental microbiology · 2024Article
- Physiological adventures inMicrobiology and molecular biology reviews : MMBR · 2024Review
- Farnesol remodels the peritoneal cavity immune environment influencingInfection and immunity · 2023Article
- Farnesol as an antifungal agent: comparisons amongFrontiers in physiology · 2023Article
- Quantitative assay for farnesol and the aromatic fusel alcohols from the fungus Candida albicans.Applied microbiology and biotechnology · 2022Article
- Saccharomyces cerevisiae RequiresmBio · 2021Article
- Longer Ubiquinone Side Chains Contribute to Enhanced Farnesol Resistance in Yeasts.Microorganisms · 2020Article
- Fungal Quorum-Sensing Molecules: A Review of Their Antifungal Effect againstJournal of fungi (Basel, Switzerland) · 2020Review
- Inhibiting roles of farnesol and HOG in morphological switching ofAmerican journal of translational research · 2020Review
- Farnesol, a Quorum-Sensing Molecule ofCells · 2019Article
- Article
- Divergent Approaches to Virulence inInternational journal of molecular sciences · 2019Review
- Role of quorum sensing and chemical communication in fungal biotechnology and pathogenesis.FEMS microbiology reviews · 2018Article
- Article
- Article
- Phenotypic Plasticity Regulates Candida albicans Interactions and Virulence in the Vertebrate Host.Frontiers in microbiology · 2016Article
- Candida albicans and Pseudomonas aeruginosa Interaction, with Focus on the Role of Eicosanoids.Frontiers in physiology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The polymorphic commensal fungus Candida albicans causes life-threatening disease via bloodstream and intra-abdominal infections in immunocompromised and transplant patients. Although host immune evasion is a common strategy used by successful human fungal pathogens, C. albicans provokes recognition by host immune cells less capable of destroying it. To accomplish this, C. albicans white cells secrete a low-molecular-weight chemoattractive stimulant(s) of macrophages, a phagocyte that they are able to survive within and eventually escape from. C. albicans opaque cells do not secrete this chemoattractive stimulant(s). We report here a physiological mechanism that contributes to the differences in the interaction of C. albicans white and opaque cells with macrophages. E,E-Farnesol, which is secreted by white cells only, is a potent stimulator of macrophage chemokinesis, whose activity is enhanced by yeast cell wall components and aromatic alcohols. E,E-farnesol results in up to an 8.5-fold increase in macrophage migration in vitro and promotes a 3-fold increase in the peritoneal infiltration of macrophages in vivo. Therefore, modulation of farnesol secretion to stimulate host immune recognition by macrophages may help explain why this commensal is such a successful pathogen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.